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学科主题: 临床医学
题名:
In vitro antifungal susceptibility of coelomycete agents of black grain eumycetoma to eight antifungals
作者: Ahmed, Sarah Abdalla1,2,3; de Hoog, G. Sybren2,3,4,5,6,7,8; Stevens, David A.9,10,11,12; Fahal, Ahmed H.13; van de Sande, Wendy W. J.14
关键词: eumycetoma ; black grain ; coelomycete ; Pleosporales
刊名: MEDICAL MYCOLOGY
发表日期: 2015-04-01
DOI: 10.1093/mmy/myu098
卷: 53, 期:3, 页:295-301
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology ; Veterinary Sciences
研究领域[WOS]: Mycology ; Veterinary Sciences
关键词[WOS]: MODIFIED NCCLS METHOD ; HYDROXIDE XTT ASSAY ; MADURELLA-MYCETOMATIS ; PYRENOCHAETA-ROMEROI ; AMPHOTERICIN-B ; ITRACONAZOLE ; ASPERGILLUS ; BURDEN
英文摘要:

Fungal mycetoma (eumycetoma) represents one of the most difficult infections to appropriately manage. The current recommended treatment is based on extensive surgical debridement combined with prolonged antifungal therapy with ketoconazole or itraconazole. Despite the different phylogenetic positions of black-grain eumycetoma species, they are all treated with the same antifungal agents. The in vitro antifungal susceptibility of coelomycetous eumycetoma agents in the order of Pleosporales presently is largely unknown. Here we determined the in vitro activity of eight antifungal agents against seven species causing human eumycetoma using the Sensititre YeastOne method. High minimum inhibitory concentrations (MICs) were found with fluconazole, caspofungin, flucytosine, and amphotericin B. Voriconazole and posaconazole were found to be active against all species tested. Of the species included in the investigation, MICs of Medicopsis romeroi differed from the rest of the mycetoma causative agents belonging to the order of the Pleosporales. We found significantly lower MICs for amphotericin B and significantly higher MICs for fluconazole, ketoconazole, and itraconazole against this species.Our results emphasised that identification of black grain mycetoma agent is important as well as performing susceptibility testing before starting of antifungal treatment.

语种: 英语
WOS记录号: WOS:000354532800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62356
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Univ Khartoum, Mycetoma Res Ctr, Khartoum, Sudan
2.Univ Khartoum, Fac Med Lab Sci, Khartoum, Sudan
3.CBS KNAW Fungal Biodivers Ctr, NL-3508 AD Utrecht, Netherlands
4.King Abdulaziz Univ, Jeddah 21413, Saudi Arabia
5.Stanford Univ, Sch Med, Calif Inst Med Res, San Jose, CA USA
6.Stanford Univ, Sch Med, Calif Inst Med Res, Stanford, CA USA
7.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, NL-1012 WX Amsterdam, Netherlands
8.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
9.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
10.Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Med Mycol, Shanghai, Peoples R China
11.Univ Fed Parana, Basic Pathol Dept, BR-80060000 Curitiba, Parana, Brazil
12.Stanford Univ, Sch Med, Dept Med, Div Infect Dis, San Jose, CA USA
13.Stanford Univ, Dept Med, Div Infect Dis, Sch Med, Stanford, CA 94305 USA
14.ErasmusMC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands

Recommended Citation:
Ahmed, Sarah Abdalla,de Hoog, G. Sybren,Stevens, David A.,et al. In vitro antifungal susceptibility of coelomycete agents of black grain eumycetoma to eight antifungals[J]. MEDICAL MYCOLOGY,2015,53(3):295-301.
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