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In vitro antifungal susceptibility of coelomycete agents of black grain eumycetoma to eight antifungals
Ahmed, Sarah Abdalla1,2,3; de Hoog, G. Sybren2,3,4,5,6,7,8; Stevens, David A.9,10,11,12; Fahal, Ahmed H.13; van de Sande, Wendy W. J.14
关键词eumycetoma black grain coelomycete Pleosporales
刊名MEDICAL MYCOLOGY
2015-04-01
DOI10.1093/mmy/myu098
53期:3页:295-301
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology ; Veterinary Sciences
研究领域[WOS]Mycology ; Veterinary Sciences
关键词[WOS]MODIFIED NCCLS METHOD ; HYDROXIDE XTT ASSAY ; MADURELLA-MYCETOMATIS ; PYRENOCHAETA-ROMEROI ; AMPHOTERICIN-B ; ITRACONAZOLE ; ASPERGILLUS ; BURDEN
英文摘要

Fungal mycetoma (eumycetoma) represents one of the most difficult infections to appropriately manage. The current recommended treatment is based on extensive surgical debridement combined with prolonged antifungal therapy with ketoconazole or itraconazole. Despite the different phylogenetic positions of black-grain eumycetoma species, they are all treated with the same antifungal agents. The in vitro antifungal susceptibility of coelomycetous eumycetoma agents in the order of Pleosporales presently is largely unknown. Here we determined the in vitro activity of eight antifungal agents against seven species causing human eumycetoma using the Sensititre YeastOne method. High minimum inhibitory concentrations (MICs) were found with fluconazole, caspofungin, flucytosine, and amphotericin B. Voriconazole and posaconazole were found to be active against all species tested. Of the species included in the investigation, MICs of Medicopsis romeroi differed from the rest of the mycetoma causative agents belonging to the order of the Pleosporales. We found significantly lower MICs for amphotericin B and significantly higher MICs for fluconazole, ketoconazole, and itraconazole against this species.Our results emphasised that identification of black grain mycetoma agent is important as well as performing susceptibility testing before starting of antifungal treatment.

语种英语
WOS记录号WOS:000354532800011
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62356
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Univ Khartoum, Mycetoma Res Ctr, Khartoum, Sudan
2.Univ Khartoum, Fac Med Lab Sci, Khartoum, Sudan
3.CBS KNAW Fungal Biodivers Ctr, NL-3508 AD Utrecht, Netherlands
4.King Abdulaziz Univ, Jeddah 21413, Saudi Arabia
5.Stanford Univ, Sch Med, Calif Inst Med Res, San Jose, CA USA
6.Stanford Univ, Sch Med, Calif Inst Med Res, Stanford, CA USA
7.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, NL-1012 WX Amsterdam, Netherlands
8.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
9.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
10.Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Med Mycol, Shanghai, Peoples R China
11.Univ Fed Parana, Basic Pathol Dept, BR-80060000 Curitiba, Parana, Brazil
12.Stanford Univ, Sch Med, Dept Med, Div Infect Dis, San Jose, CA USA
13.Stanford Univ, Dept Med, Div Infect Dis, Sch Med, Stanford, CA 94305 USA
14.ErasmusMC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
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GB/T 7714
Ahmed, Sarah Abdalla,de Hoog, G. Sybren,Stevens, David A.,et al. In vitro antifungal susceptibility of coelomycete agents of black grain eumycetoma to eight antifungals[J]. MEDICAL MYCOLOGY,2015,53(3):295-301.
APA Ahmed, Sarah Abdalla,de Hoog, G. Sybren,Stevens, David A.,Fahal, Ahmed H.,&van de Sande, Wendy W. J..(2015).In vitro antifungal susceptibility of coelomycete agents of black grain eumycetoma to eight antifungals.MEDICAL MYCOLOGY,53(3),295-301.
MLA Ahmed, Sarah Abdalla,et al."In vitro antifungal susceptibility of coelomycete agents of black grain eumycetoma to eight antifungals".MEDICAL MYCOLOGY 53.3(2015):295-301.
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