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Molecular cloning, characterization and expression of Lrrc10: a novel mouse heart-specific member of leucine-rich repeat superfamily
Chen, XG; Li, Y; Zhao, RB; Pei, XR; Zang, MX; Gao, LF; Chen, J
关键词Lrrc10 leucine rich repeat heart-specific novel gene
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
2003-08-01
30期:4页:617-622
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]SEQUENCE TAGS ; IDENTIFICATION ; RECEPTOR ; PROTEINS ; DISEASE ; FAMILY ; TUMOR ; GENES
英文摘要

A novel mouse heart-specific gene, Lrrc10 (GenBank Ace No. AF527781), was cloned from mouse embryo heart by application of EST assembly and RT-PCR. The cDNA of Lrrc10 was 1 410 bp and intronless. This gene was mapped to mouse chromosome 10D2 by BLAST search to mouse genome. The longest ORF of the cDNA encoded a putative proteins of 274 amino acids. Seven leucine rich repeat motifs were present between 53 amino acid to 212 amino acid. No known gene or protein was significantly homologous to Lrrc10 or its deduced protein. However, XM_137268, a predicted human gene submitted by NCBI genome annotation project, shared high identity to Lrrc10. It may be concluded that XM_137268 was the uncloned human orthologue of Lrrc10. BLAST to EST database showed that cDNA of Lrrc10 was supported by 18 ESTs, all of them were from mouse heart. RT-PCR performed on a panel of different mouse tissues demonstrated that expression of Lrrc10 was strongly in heart, low in lung, not or very weakly in other tissues. These results suggest that Lrrc10 is a novel heart specific member of leucine rich repeat superfamily. As far as, no heart-specific member of this family was reported before.

语种中文
WOS记录号WOS:000184947500022
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62360
Collection北京大学公共卫生学院
作者单位1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Lab Mol Toxic & Dev Mol Biol, Beijing 100083, Peoples R China
2.Sichuan Univ Sci & Technol, Dept Bioengn, Chengdu 610039, Peoples R China
Recommended Citation
GB/T 7714
Chen, XG,Li, Y,Zhao, RB,et al. Molecular cloning, characterization and expression of Lrrc10: a novel mouse heart-specific member of leucine-rich repeat superfamily[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2003,30(4):617-622.
APA Chen, XG.,Li, Y.,Zhao, RB.,Pei, XR.,Zang, MX.,...&Chen, J.(2003).Molecular cloning, characterization and expression of Lrrc10: a novel mouse heart-specific member of leucine-rich repeat superfamily.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,30(4),617-622.
MLA Chen, XG,et al."Molecular cloning, characterization and expression of Lrrc10: a novel mouse heart-specific member of leucine-rich repeat superfamily".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 30.4(2003):617-622.
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