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学科主题: 基础医学
题名:
A meta-analysis of the long-term effects of chronic pancreatitis surgical treatments: duodenum-preserving pancreatic head resection versus pancreatoduodenectomy
作者: Lu Wen-ping1; Shi Qing2; Zhang Wen-zhi1; Cai Shou-wang1; Jiang Kai1; Dong Jia-hong1
关键词: chronic pancreatitis ; surgical treatments ; long-term postoperative effect ; meta-analysis
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-01-05
DOI: 10.3760/cma.j.issn.0366-6999.20112607
卷: 126, 期:1, 页:147-153
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: WHIPPLE PROCEDURE ; RANDOMIZED-TRIAL ; FOLLOW-UP ; BEGER ; PRESERVATION ; EXPERIENCE ; DRAINAGE ; FREY
英文摘要:

Background Surgery is regarded as the most effective treatment to relieve pain and reduce complications in chronic pancreatitis (CP). Two major strategies exist: duodenum-preserving pancreatic head resection (DPPHR) and pancreatoduodenectomy (PD). Many studies suggest that DPPHR offers advantages during surgery and in the short-term; however, the long-term effects have not been thoroughly investigated. We analyzed the long-term outcomes of DPPHR and PD, over follow-up times of at least 1 year, to determine the optimal surgical treatment for CP.

Methods We systemically reviewed all CP surgical treatment reports, and only included randomized controlled trials (RCT) comparing DPPHR and PD, excluding unqualified studies using several pre-specified criteria. When multiple publications of a single trial were found, the most comprehensive current data were selected. Characteristics of the study populations and long-term postoperative outcome parameters were collected. The quality of the studies and data was analyzed using RevMan 4.2 software.

Results Five trials were qualified for meta-analysis, with 261 participants in total (114 in the DPPHR group and 147 in the PD group). There were no significant differences in the age, gender, or indications for surgery of each group. At the mean of 5.7-year (1-14 years) follow-up examination, DPPHR and PD resulted in equally effective pain relief, exocrine and endocrine function, and similar mortality rates (P > 0.05); however, DPPHR patients had improved global quality of life and weight gain, and reduced diarrhea and fatigue (P < 0.05).

Conclusion DPPHR and PD result in equal pain relief, mortality, and pancreatic function; however, DPPHR provides superior long-term outcomes.

语种: 英语
所属项目编号: 30772493 ; 81170429
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000319793700027
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62364
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Dept Hepatobiliary Surg, Beijing 100853, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China

Recommended Citation:
Lu Wen-ping,Shi Qing,Zhang Wen-zhi,et al. A meta-analysis of the long-term effects of chronic pancreatitis surgical treatments: duodenum-preserving pancreatic head resection versus pancreatoduodenectomy[J]. CHINESE MEDICAL JOURNAL,2013,126(1):147-153.
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