IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Effect of high myopia on 24-hour intraocular pressure in patients with primary open-angle glaucoma
Yang Ying-xin1,2; Wang Ning-li1; Wu Lie2; Zhen Yi1; Wang Tao1; Ren Cai-xia3; Peng Xiao-xia4; Hao Jie1; Xia Yan-ting5
关键词high tension primary open angle glaucoma intraocular pressure high myopia
刊名CHINESE MEDICAL JOURNAL
2012-04-05
DOI10.3760/cma.j.issn.0366-6999.2012.07.017
125期:7页:1282-1286
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者Beijing Municipal Science &amp ; Technology Commission ; Beijing Municipal Science &amp ; Technology Commission
研究领域[WOS]General & Internal Medicine
关键词[WOS]VISUAL-FIELD PROGRESSION ; OCULAR HYPERTENSION ; RISK-FACTOR ; AXIAL LENGTH ; FLUCTUATION ; TRIAL ; SUSCEPTIBILITY ; INTERVENTION ; ASSOCIATION ; PATTERN
英文摘要

Background As intraocular pressure (IOP) and IOP fluctuation are known risk factors for glaucoma, it is important to understand the effects of high myopia on these ocular parameters. The aim of this study was to investigate if primary open-angle glaucoma (POAG) patients with high myopia exhibit higher IOP and greater IOP fluctuations at resting conditions over 24 hours.

Methods We designed a prospective control clinical study. Eighty-two eyes of 82 high-tension Chinese POAG patients only on prostaglandin analogue locally were divided into 3 groups according to various myopic grades (<-6.0 D, n=27 and between -0.76 and -5.99 D, n=33) or without myopia (-0.75 to 0.75 D, n=22). Single time IOP at 10 am, mean corrected 24-hour IOP, mean corrected night IOP, 24-hour IOP fluctuation and IOPs of 10 am, 2 pm, 6 pm, 10 pm, 2 am, 6 am and 8 am were measured.

Results The IOP was higher in POAG patients with high myopia over those POAG alone in three ways: the elevated IOP value was 0.65 mmHg measured in single time IOP at 10 am, 0.84 mmHg in mean corrected 24-hour IOP, 0.97 mmHg in mean corrected night IOP. The 24-hour IOP fluctuation was lower in the two myopia groups than in non-myopia group. Further, using repeated measurement analysis of variance, there was no statistical significance among groups regarding the IOPs at the seven time points (P=0.77) and there was no interaction between groups and time points (P=0.71), but the difference of IOPs at the seven time points in same group was statistically significant (P=0.01).

Conclusion High-tension POAG patients with high myopia, even on pharmacological glaucoma therapy, still have higher IOP, but 24-hour IOP fluctuation at resting conditions was lower in these patients. Chin Med J 2012;125(7):1282-1286

语种英语
所属项目编号Z090507017709009
资助者Beijing Municipal Science &amp ; Technology Commission ; Beijing Municipal Science &amp ; Technology Commission
WOS记录号WOS:000302882600017
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62365
Collection北京大学基础医学院
作者单位1.Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China
2.China Acad Chinese Med Sci, Guanganmen Hosp, Dept Ophthalmol, Beijing 100053, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Anat Histol & Embryol, Beijing 100191, Peoples R China
4.Capital Med Univ, Sch Publ Hlth & Family Med, Dept Epidemiol & Biostat, Beijing 100069, Peoples R China
5.Beijing Univ Chinese Med, Dept Ophthalmol, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Yang Ying-xin,Wang Ning-li,Wu Lie,et al. Effect of high myopia on 24-hour intraocular pressure in patients with primary open-angle glaucoma[J]. CHINESE MEDICAL JOURNAL,2012,125(7):1282-1286.
APA Yang Ying-xin.,Wang Ning-li.,Wu Lie.,Zhen Yi.,Wang Tao.,...&Xia Yan-ting.(2012).Effect of high myopia on 24-hour intraocular pressure in patients with primary open-angle glaucoma.CHINESE MEDICAL JOURNAL,125(7),1282-1286.
MLA Yang Ying-xin,et al."Effect of high myopia on 24-hour intraocular pressure in patients with primary open-angle glaucoma".CHINESE MEDICAL JOURNAL 125.7(2012):1282-1286.
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