Institutional Repository of Peking University School of Basic Medical Sciences
|Effect of high myopia on 24-hour intraocular pressure in patients with primary open-angle glaucoma|
|Yang Ying-xin1,2; Wang Ning-li1; Wu Lie2; Zhen Yi1; Wang Tao1; Ren Cai-xia3; Peng Xiao-xia4; Hao Jie1; Xia Yan-ting5|
|关键词||high tension primary open angle glaucoma intraocular pressure high myopia|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||VISUAL-FIELD PROGRESSION ; OCULAR HYPERTENSION ; RISK-FACTOR ; AXIAL LENGTH ; FLUCTUATION ; TRIAL ; SUSCEPTIBILITY ; INTERVENTION ; ASSOCIATION ; PATTERN|
Background As intraocular pressure (IOP) and IOP fluctuation are known risk factors for glaucoma, it is important to understand the effects of high myopia on these ocular parameters. The aim of this study was to investigate if primary open-angle glaucoma (POAG) patients with high myopia exhibit higher IOP and greater IOP fluctuations at resting conditions over 24 hours.
Methods We designed a prospective control clinical study. Eighty-two eyes of 82 high-tension Chinese POAG patients only on prostaglandin analogue locally were divided into 3 groups according to various myopic grades (<-6.0 D, n=27 and between -0.76 and -5.99 D, n=33) or without myopia (-0.75 to 0.75 D, n=22). Single time IOP at 10 am, mean corrected 24-hour IOP, mean corrected night IOP, 24-hour IOP fluctuation and IOPs of 10 am, 2 pm, 6 pm, 10 pm, 2 am, 6 am and 8 am were measured.
Results The IOP was higher in POAG patients with high myopia over those POAG alone in three ways: the elevated IOP value was 0.65 mmHg measured in single time IOP at 10 am, 0.84 mmHg in mean corrected 24-hour IOP, 0.97 mmHg in mean corrected night IOP. The 24-hour IOP fluctuation was lower in the two myopia groups than in non-myopia group. Further, using repeated measurement analysis of variance, there was no statistical significance among groups regarding the IOPs at the seven time points (P=0.77) and there was no interaction between groups and time points (P=0.71), but the difference of IOPs at the seven time points in same group was statistically significant (P=0.01).
Conclusion High-tension POAG patients with high myopia, even on pharmacological glaucoma therapy, still have higher IOP, but 24-hour IOP fluctuation at resting conditions was lower in these patients. Chin Med J 2012;125(7):1282-1286
|资助机构||Beijing Municipal Science & ; Technology Commission|
|作者单位||1.Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China|
2.China Acad Chinese Med Sci, Guanganmen Hosp, Dept Ophthalmol, Beijing 100053, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Anat Histol & Embryol, Beijing 100191, Peoples R China
4.Capital Med Univ, Sch Publ Hlth & Family Med, Dept Epidemiol & Biostat, Beijing 100069, Peoples R China
5.Beijing Univ Chinese Med, Dept Ophthalmol, Beijing 100029, Peoples R China
|Yang Ying-xin,Wang Ning-li,Wu Lie,et al. Effect of high myopia on 24-hour intraocular pressure in patients with primary open-angle glaucoma[J]. CHINESE MEDICAL JOURNAL,2012,125(7):1282-1286.|
|APA||Yang Ying-xin.,Wang Ning-li.,Wu Lie.,Zhen Yi.,Wang Tao.,...&Xia Yan-ting.(2012).Effect of high myopia on 24-hour intraocular pressure in patients with primary open-angle glaucoma.CHINESE MEDICAL JOURNAL,125(7),1282-1286.|
|MLA||Yang Ying-xin,et al."Effect of high myopia on 24-hour intraocular pressure in patients with primary open-angle glaucoma".CHINESE MEDICAL JOURNAL 125.7(2012):1282-1286.|