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学科主题: 临床医学
题名:
An Implantable Sacral Nerve Root Recording and Stimulation System for Micturition Function Restoration
作者: Wang, Yuan1; Zhang, Xu1; Liu, Ming1; Pei, Weihua1; Wang, Kaifeng2; Chen, Hongda1
关键词: neural prosthesis ; functional electrical stimulation ; closed-loop bladder control ; acute animal experiment ; spinal cord injury
刊名: IEICE TRANSACTIONS ON INFORMATION AND SYSTEMS
发表日期: 2014-10-01
DOI: 10.1587/transinf.2013EDP7395
卷: E97D, 期:10, 页:2790-2801
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Computer Science, Information Systems ; Computer Science, Software Engineering
研究领域[WOS]: Computer Science
关键词[WOS]: SPINAL-CORD-INJURY ; BLADDER CONTRACTIONS ; DIELECTRIC-PROPERTIES ; BIOLOGICAL TISSUES ; CMOS TECHNOLOGY ; PUDENDAL NERVE ; PRESSURE ; ONSET ; DOGS ; ENG
英文摘要:

This paper provides a prototype neural prosthesis system dedicated to restoring continence and micturition function for patients with lower urinary tract diseases, such as detrusor hyperreflexia and detrusor-sphincter dyssynergia. This system consists of an ultra low-noise electroneurogram (ENG) signal recording module, a bi-phasic electrical stimulator module and a control unit for closed-loop bladder monitoring and controlling. In order to record extremely weak ENG signal from extradural sacral nerve roots, the system provides a programmable gain from 80 dB to 117 dB. By combining of advantages of commercial-off-the-shelf (COTS) electronics and custom designed IC, the recording front-end acquires a fairly low input-referred noise (IRN) of 0.69 mu V-rms under 300 Hz to 3 kHz and high area-efficiency. An on-chip multi-steps single slope analog-to-digital converter (ADC) is used to digitize the ENG signals at sampling rate of 10 kSPS and achieves an effective number of bits (ENOB) of 12.5. A bi-phasic current stimulus generator with wide voltage supply range (+/-0.9 V to +/-12.5 V) and variable output current amplitude (0-500 mu A) is introduced to overcome patient-depended impedance between electrode and tissue electrolyte. The total power consumption of the entire system is 5.61 mW. Recording and stimulation function of this system is switched by control unit with time division multiplexing strategy. The functionality of this proposed prototype system has been successfully verified through in-vivo experiments from dogs extradural sacral nerve roots.

语种: 英语
所属项目编号: 61076023 ; 61178051 ; 2011CB933203 ; 2012AA030308
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China ; National High Technology Research &amp ; Development Program of China
WOS记录号: WOS:000348141100025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62367
Appears in Collections:北京大学第二临床医学院_脊柱外科_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Semicond, State Key Lab Integrated Optoelectron, Beijing 100083, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Spinal Surg, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Yuan,Zhang, Xu,Liu, Ming,et al. An Implantable Sacral Nerve Root Recording and Stimulation System for Micturition Function Restoration[J]. IEICE TRANSACTIONS ON INFORMATION AND SYSTEMS,2014,E97D(10):2790-2801.
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