IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Specific antifungal susceptibility profiles of opportunists in the Fusarium fujikuroi complex
Al-Hatmi, Abdullah M. S.1,2,3; van Diepeningen, Anne D.1; Curfs-Breuker, Ilse4; de Hoog, G. Sybren1,2,5,6,7,8,9; Meis, Jacques F.4,10
关键词molecular identification multiresistant triazole agents isavuconazole
刊名JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
2015-04-01
DOI10.1093/jac/dku505
70期:4页:1068-1071
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
资助者Ministry of Health, Oman ; Ministry of Health, Oman
研究领域[WOS]Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]AMPHOTERICIN-B ; VORICONAZOLE ; SCEDOSPORIUM ; ITRACONAZOLE ; POSACONAZOLE ; FLUCONAZOLE ; ASPERGILLUS ; YEASTS ; FUNGI ; SPP.
英文摘要

Objectives: The aim of the present study was to evaluate and assess the in vitro activity of eight drugs, including the new azole isavuconazole, against 81 strains representing 13 species of the Fusarium fujikuroi species complex.

Methods: A total of 81 Fusarium spp. isolates, within the F. fujikuroi species complex, were identified by molecular methods and tested according to CLSI M38-A2. Eight antifungal compounds, including the new azole isavuconazole, were tested. Isolates were selected to represent the widest variety of geographical regions and to include clinical as well as environmental strains.

Results: Susceptibility profiles differed between and within species, with Fusarium verticillioides showing the lowest MICs and Fusarium nygamai the highest MICs. Amphotericin B was the most active drug, followed by voriconazole, posaconazole, isavuconazole and natamycin. The remaining antifungals (fluconazole, itraconazole and micafungin) showed poor activity with MIC/minimum effective concentration values of >= 32, >= 16 and >8 mg/L, respectively.

Conclusions: Resistance patterns in the F. fujikuroi species complex are species specific and therefore identification down to species level is important for the choice of antifungal treatment.

语种英语
所属项目编号28/2014
资助者Ministry of Health, Oman ; Ministry of Health, Oman
WOS记录号WOS:000354708600016
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62371
专题北京大学第一临床医学院_皮肤性病科
作者单位1.CBS KNAW Fungal Biodivers Ctr, NL-3508 AD Utrecht, Netherlands
2.Ibri Hosp, Minist Hlth, Directorate Gen Hlth Serv, Muscat, Oman
3.King Abdulaziz Univ, Jeddah 21413, Saudi Arabia
4.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
5.Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
6.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
7.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
8.Second Mil Med Univ, Shanghai Inst Med Mycol, Changzheng Hosp, Shanghai, Peoples R China
9.Univ Fed Parana State, Basic Pathol Dept, Curitiba, Parana, Brazil
10.Radboud Univ Nijmegen Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands
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GB/T 7714
Al-Hatmi, Abdullah M. S.,van Diepeningen, Anne D.,Curfs-Breuker, Ilse,et al. Specific antifungal susceptibility profiles of opportunists in the Fusarium fujikuroi complex[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,2015,70(4):1068-1071.
APA Al-Hatmi, Abdullah M. S.,van Diepeningen, Anne D.,Curfs-Breuker, Ilse,de Hoog, G. Sybren,&Meis, Jacques F..(2015).Specific antifungal susceptibility profiles of opportunists in the Fusarium fujikuroi complex.JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,70(4),1068-1071.
MLA Al-Hatmi, Abdullah M. S.,et al."Specific antifungal susceptibility profiles of opportunists in the Fusarium fujikuroi complex".JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 70.4(2015):1068-1071.
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