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学科主题: 临床医学
题名:
Specific antifungal susceptibility profiles of opportunists in the Fusarium fujikuroi complex
作者: Al-Hatmi, Abdullah M. S.1,2,3; van Diepeningen, Anne D.1; Curfs-Breuker, Ilse4; de Hoog, G. Sybren1,2,5,6,7,8,9; Meis, Jacques F.4,10
关键词: molecular identification ; multiresistant ; triazole agents ; isavuconazole
刊名: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
发表日期: 2015-04-01
DOI: 10.1093/jac/dku505
卷: 70, 期:4, 页:1068-1071
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: AMPHOTERICIN-B ; VORICONAZOLE ; SCEDOSPORIUM ; ITRACONAZOLE ; POSACONAZOLE ; FLUCONAZOLE ; ASPERGILLUS ; YEASTS ; FUNGI ; SPP.
英文摘要:

Objectives: The aim of the present study was to evaluate and assess the in vitro activity of eight drugs, including the new azole isavuconazole, against 81 strains representing 13 species of the Fusarium fujikuroi species complex.

Methods: A total of 81 Fusarium spp. isolates, within the F. fujikuroi species complex, were identified by molecular methods and tested according to CLSI M38-A2. Eight antifungal compounds, including the new azole isavuconazole, were tested. Isolates were selected to represent the widest variety of geographical regions and to include clinical as well as environmental strains.

Results: Susceptibility profiles differed between and within species, with Fusarium verticillioides showing the lowest MICs and Fusarium nygamai the highest MICs. Amphotericin B was the most active drug, followed by voriconazole, posaconazole, isavuconazole and natamycin. The remaining antifungals (fluconazole, itraconazole and micafungin) showed poor activity with MIC/minimum effective concentration values of >= 32, >= 16 and >8 mg/L, respectively.

Conclusions: Resistance patterns in the F. fujikuroi species complex are species specific and therefore identification down to species level is important for the choice of antifungal treatment.

语种: 英语
所属项目编号: 28/2014
项目资助者: Ministry of Health, Oman
WOS记录号: WOS:000354708600016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62371
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.CBS KNAW Fungal Biodivers Ctr, NL-3508 AD Utrecht, Netherlands
2.Ibri Hosp, Minist Hlth, Directorate Gen Hlth Serv, Muscat, Oman
3.King Abdulaziz Univ, Jeddah 21413, Saudi Arabia
4.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
5.Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
6.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
7.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
8.Second Mil Med Univ, Shanghai Inst Med Mycol, Changzheng Hosp, Shanghai, Peoples R China
9.Univ Fed Parana State, Basic Pathol Dept, Curitiba, Parana, Brazil
10.Radboud Univ Nijmegen Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands

Recommended Citation:
Al-Hatmi, Abdullah M. S.,van Diepeningen, Anne D.,Curfs-Breuker, Ilse,et al. Specific antifungal susceptibility profiles of opportunists in the Fusarium fujikuroi complex[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,2015,70(4):1068-1071.
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