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学科主题: 临床医学
题名:
Prevalence of antinuclear and anti-liver-kidney-microsome type-1 antibodies in patients with chronic hepatitis C in China
作者: Bai Li1; Feng Zhen-ru2; Lu Hai-ying1; Li Wen-gang1; Yu Min1; Xu Xiao-yuan1
关键词: hepatitis C, chronic ; autoantibodies ; hepatitis, autoimmune
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2009-01-05
DOI: 10.3760/cma.j.issn.0366-6999.2009.01.002
卷: 122, 期:1, 页:5-9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ORGAN-SPECIFIC AUTOANTIBODIES ; AUTOIMMUNE HEPATITIS ; VIRUS-INFECTION ; GENERAL-POPULATION ; DISEASE ; THERAPY ; HCV ; INTERFERON ; FREQUENCY ; CHILDREN
英文摘要:

Background Hepatitis C virus (HCV) infection may induce autoimmune response and autoantibodies can be detected in chronic hepatitis C (CHC) patients. However, the reported positive rate of autoantibodies in CHC patients in China varies considerably. In this study, we investigated the prevalence of antinuclear antibodies (ANA) and anti-liver-kidney-microsome type 1 autoantibodies (anti-LKM-1) in a large cohort of CHC patients, and analyzed the factors related to the presence of the autoantibodies.

Methods A total of 360 CHC patients were enrolled in this study. Serum ANA and anti-LKM-1 were detected by indirect immunofluorescence and enzyme-linked immunosorbent assay, respectively. Clinical analysis was performed to disclose the related factors to autoantibody production.

Results The prevalence of ANA and anti-LKM-1 in CHC patients was 12.5% (45/360) and 2.5% (9/360), respectively. Women had a higher prevalence than men (18.9% vs 11.4%, P=0.046). Patients with positive autoantibodies had lower HCV RNA levels (1.2x10(7) copies/L vs 7.2x10(7) Copies/L, P < 0.05). Positive ANA was associated with higher serum globulin (P < 0.05). Stratified analysis showed that there were no significant differences in age, HCV genotype, disease course, clinical stage, prevalence of cirrhosis and interferon therapy between autoantibody-positive and -negative subgroups.

Conclusion Autoantibodies can be induced in the course of CHC, and some CHC patients can even develop autoimmune hepatitis.

语种: 英语
所属项目编号: 2004BA7181310
项目资助者: National Tenth Five-Year Key Project of Science and Technology of China
WOS记录号: WOS:000262693100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62374
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China

Recommended Citation:
Bai Li,Feng Zhen-ru,Lu Hai-ying,et al. Prevalence of antinuclear and anti-liver-kidney-microsome type-1 antibodies in patients with chronic hepatitis C in China[J]. CHINESE MEDICAL JOURNAL,2009,122(1):5-9.
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