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IR@PKUHSC  > 北京大学第一临床医学院  > 肿瘤化疗科  > 期刊论文
学科主题: 临床医学
题名:
Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma
作者: Gao, Xian-Shu; Qiao, Xueying; Wu, Fengpeng; Cao, Li; Meng, Xianli; Dong, Zhiming; Wang, Xiaoling; Gao, Guodong; Wu, Tsung-Teh; Komaki, Ritsuko; Chang, Joe Y.
关键词: esophageal carcinoma ; adenocarcinoma of gastroesophageal junction ; esophagectomy ; microscopic spread ; lymph node metastasis ; clinical target volume
刊名: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
发表日期: 2007-02-01
DOI: 10.1016/j.ijrobp.2006.09.015
卷: 67, 期:2, 页:389-396
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: SQUAMOUS-CELL CARCINOMA ; LYMPH-NODE METASTASIS ; RESECTION MARGIN ; ESOPHAGOGASTRIC JUNCTION ; INTRAMURAL METASTASIS ; CANCER ; CHEMORADIOTHERAPY ; SPREAD ; CARDIA ; ADENOCARCINOMA
英文摘要:

Purpose: To clarify the radiotherapy clinical target volume (CTV) margin needed for esophageal squamous-cell carcinoma (SCC) and gastroesophageal junction (GEJ) adenocarcinoma.

Methods and Materials: Surgical specimens of esophageal SCC (n = 34) and GEJ adenocarcinoma (n = 32) were prospectively collected and analyzed for microscopic spread along the esophagus and GEJ both proximally and distally from gross tumor and for lymph node ILN) metastasis.

Results: For SCC, the mean microscopic spread beyond the gross tumor was 10.5 +/- 13.5 mm proximally (< 30 mm in 32 of 34 cases) and 10.6 +/- 8.1 mm distally (< 30 mm in 33 of 34 cases). For GEJ adenocarcinoma, the spread was 10.3 +/- 7.2 mm proximally (< 30 mm in 29 of 29 cases) and 18.3 +/- 16.3 mm distally (< 30 mm in 27 of 32 cases). The extent of microscopic spread of cancer was significantly associated with pathologic T stage (P = 0.012). LN metastases were observed in 12 (35%) of 34 patients with middle and lower esophageal SCC and 15 (47%) of 32 patients with GEJ adenocarcinoma.

Conclusions: The extent of microscopic spread within esophagus (recommended CTV margin) was < 30 mm in about 94 of cases of esophageal cancer, except for distal microscopic spread in GEJ adenocarcinoma, in which 50 mm was needed to cover about 94% of cases. (c) 2007 Elsevier Inc.

语种: 英语
WOS记录号: WOS:000243669300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62384
Appears in Collections:北京大学第一临床医学院_肿瘤化疗科_期刊论文

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作者单位: 1.Univ Texas, MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
2.Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
3.Hebei Med Univ, Hosp 4, Dept Radiat Oncol, Shijiazhuang, Peoples R China
4.Hebei Med Univ, Hosp 4, Dept Thorac Surg, Shijiazhuang, Peoples R China
5.Hebei Med Univ, Hosp 4, Dept Pathol, Shijiazhuang, Peoples R China
6.Beijing Univ, Hosp 1, Dept Radiat Oncol, Beijing, Peoples R China

Recommended Citation:
Gao, Xian-Shu,Qiao, Xueying,Wu, Fengpeng,et al. Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2007,67(2):389-396.
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