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学科主题临床医学
Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma
Gao, Xian-Shu; Qiao, Xueying; Wu, Fengpeng; Cao, Li; Meng, Xianli; Dong, Zhiming; Wang, Xiaoling; Gao, Guodong; Wu, Tsung-Teh; Komaki, Ritsuko; Chang, Joe Y.
关键词esophageal carcinoma adenocarcinoma of gastroesophageal junction esophagectomy microscopic spread lymph node metastasis clinical target volume
刊名INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
2007-02-01
DOI10.1016/j.ijrobp.2006.09.015
67期:2页:389-396
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; LYMPH-NODE METASTASIS ; RESECTION MARGIN ; ESOPHAGOGASTRIC JUNCTION ; INTRAMURAL METASTASIS ; CANCER ; CHEMORADIOTHERAPY ; SPREAD ; CARDIA ; ADENOCARCINOMA
英文摘要

Purpose: To clarify the radiotherapy clinical target volume (CTV) margin needed for esophageal squamous-cell carcinoma (SCC) and gastroesophageal junction (GEJ) adenocarcinoma.

Methods and Materials: Surgical specimens of esophageal SCC (n = 34) and GEJ adenocarcinoma (n = 32) were prospectively collected and analyzed for microscopic spread along the esophagus and GEJ both proximally and distally from gross tumor and for lymph node ILN) metastasis.

Results: For SCC, the mean microscopic spread beyond the gross tumor was 10.5 +/- 13.5 mm proximally (< 30 mm in 32 of 34 cases) and 10.6 +/- 8.1 mm distally (< 30 mm in 33 of 34 cases). For GEJ adenocarcinoma, the spread was 10.3 +/- 7.2 mm proximally (< 30 mm in 29 of 29 cases) and 18.3 +/- 16.3 mm distally (< 30 mm in 27 of 32 cases). The extent of microscopic spread of cancer was significantly associated with pathologic T stage (P = 0.012). LN metastases were observed in 12 (35%) of 34 patients with middle and lower esophageal SCC and 15 (47%) of 32 patients with GEJ adenocarcinoma.

Conclusions: The extent of microscopic spread within esophagus (recommended CTV margin) was < 30 mm in about 94 of cases of esophageal cancer, except for distal microscopic spread in GEJ adenocarcinoma, in which 50 mm was needed to cover about 94% of cases. (c) 2007 Elsevier Inc.

语种英语
WOS记录号WOS:000243669300011
引用统计
被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62384
专题北京大学第一临床医学院_肿瘤化疗科
作者单位1.Univ Texas, MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
2.Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
3.Hebei Med Univ, Hosp 4, Dept Radiat Oncol, Shijiazhuang, Peoples R China
4.Hebei Med Univ, Hosp 4, Dept Thorac Surg, Shijiazhuang, Peoples R China
5.Hebei Med Univ, Hosp 4, Dept Pathol, Shijiazhuang, Peoples R China
6.Beijing Univ, Hosp 1, Dept Radiat Oncol, Beijing, Peoples R China
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GB/T 7714
Gao, Xian-Shu,Qiao, Xueying,Wu, Fengpeng,et al. Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2007,67(2):389-396.
APA Gao, Xian-Shu.,Qiao, Xueying.,Wu, Fengpeng.,Cao, Li.,Meng, Xianli.,...&Chang, Joe Y..(2007).Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma.INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,67(2),389-396.
MLA Gao, Xian-Shu,et al."Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma".INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 67.2(2007):389-396.
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