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Effect on blood pressure control of switching from valsartan monotherapy to losartan/hydro-chlorothiazide in Asian patients with hypertension: results of a multicentre open-label trial
Watanabe, Luis A.; Wei, Meng; Sun, Ningling; Kim, Dongsoo; Chiang, Chern-En; Ke, Yuannan; Tseng, Chuen-Den; Coloma, Ricardo; Vala, M.; Massaad, R.; Feig, P.; Guptha, S.
关键词combination therapy hydrochlorothiazide hypertension losartan
刊名CURRENT MEDICAL RESEARCH AND OPINION
2006-10-01
DOI10.1185/030079906X132514
22期:10页:1955-1964
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal ; Medicine, Research & Experimental
研究领域[WOS]General & Internal Medicine ; Research & Experimental Medicine
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; TO-MODERATE HYPERTENSION ; COMBINATION THERAPY ; DOUBLE-BLIND ; ANTIHYPERTENSIVE EFFICACY ; HYDROCHLOROTHIAZIDE ; MANAGEMENT ; JAPAN ; RISK ; HYPERURICEMIA
英文摘要

Study design: An open- label, multicentre study was conducted to evaluate the antihypertensive efficacy of a 4-week course of losartan 50 mg plus hydrochlorothiazide 12.5 mg in Asian patients with essential hypertension whose blood pressure had previously been treated with but not controlled by valsartan 80 mg.

Methods: A total of 237 eligible patients with mean trough sitting diastolic blood pressure SiDBP) 95 - 115 mmHg and a mean trough sitting systolic blood pressure ( SiSBP) < 190 mmHg entered the baseline period of treatment with valsartan 80 mg/ day for 4 weeks. Those ( n = 165) whose SiDBP remained > 90 mmHg and who were not excluded for other reasons were then switched to a single-tablet formulation of losartan 50 mg/ hydrochlorothiazide 12.5 mg combination once daily for a further 4 weeks.

Results: Mean SiDBP ( study primary endpoint) at the end of combination therapy was reduced to 86.9 mmHg from 95.2 mmHg. SiSBP ( study secondary endpoint) was reduced to 132.6 mmHg from 140.7 mmHg. Mean reductions after switching from valsartan 80 mg to losartan 50 mg/hydrochlorothiazide 12.5 mg were thus 8.3 and 8.1 mmHg for SiDBP and SiSBP, respectively ( p <= 0.001 for both outcomes). The goal of SiDBP <= 90 mmHg was attained in 72% of the patients previously not controlled to the same level by valsartan 80 mg/day. Combination therapy with losartan 50 mg/hydrochlorothiazide 12.5 mg was generally well tolerated. Mean compliance with the losartan 50 mg/hydrochlorothiazide 12.5 mg combination was > 99%.

Conclusion: These results demonstrate that in Asian patients who do not reach the goal of mean trough SiDBP <= 90 mmHg with valsartan monotherapy at 80 mg once-daily, switching to a single-tablet combination of losartan 50 mg/hydrochlorothiazide 12.5 mg once-daily is well tolerated, provides effective control of blood pressure and is an excellent choice to achieve blood pressure reduction goals.

语种英语
WOS记录号WOS:000241894200013
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62387
专题北京大学第二临床医学院_心血管内科
作者单位1.Clin San Borja, Lima, Peru
2.Merck Res Labs, Brussels, Belgium
3.Merck Res Labs, Rahway, NJ USA
4.Merck & Co Inc, Whitehouse Stn, NJ 08889 USA
5.Jesus Maria, Clin San Felipe, Lima, Peru
6.Shanghai Sixth Peoples Hosp, Dept Cardiol, Shanghai, Peoples R China
7.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing, Peoples R China
8.Inje Univ, Busan Paik Hosp, Div Cardiol, Pusan, South Korea
9.Natl Yang Ming Univ, Taipei 112, Taiwan
10.Vet Gen Hosp, Taipei, Taiwan
11.Natl Taiwan Univ Hosp, Taipei, Taiwan
12.China Japan Friendship Hosp, Cardiovasc Dept, He Ping Li, Peoples R China
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GB/T 7714
Watanabe, Luis A.,Wei, Meng,Sun, Ningling,et al. Effect on blood pressure control of switching from valsartan monotherapy to losartan/hydro-chlorothiazide in Asian patients with hypertension: results of a multicentre open-label trial[J]. CURRENT MEDICAL RESEARCH AND OPINION,2006,22(10):1955-1964.
APA Watanabe, Luis A..,Wei, Meng.,Sun, Ningling.,Kim, Dongsoo.,Chiang, Chern-En.,...&Guptha, S..(2006).Effect on blood pressure control of switching from valsartan monotherapy to losartan/hydro-chlorothiazide in Asian patients with hypertension: results of a multicentre open-label trial.CURRENT MEDICAL RESEARCH AND OPINION,22(10),1955-1964.
MLA Watanabe, Luis A.,et al."Effect on blood pressure control of switching from valsartan monotherapy to losartan/hydro-chlorothiazide in Asian patients with hypertension: results of a multicentre open-label trial".CURRENT MEDICAL RESEARCH AND OPINION 22.10(2006):1955-1964.
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