IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科
学科主题临床医学
HEPATIC PERFUSION PARAMETERS OF CONTRAST-ENHANCED ULTRASONOGRAPHY CORRELATE WITH THE SEVERITY OF CHRONIC LIVER DISEASE
Liu, Dong1; Qian, Linxue1; Wang, Jinrui2; Hu, Xiangdong1; Qiu, Lanyan1
关键词Contrast-enhanced ultrasonography Cirrhosis Hepatic perfusion
刊名ULTRASOUND IN MEDICINE AND BIOLOGY
2014-11-01
DOI10.1016/j.ultrasmedbio.2014.05.011
40期:11页:2556-2563
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]ARTERIAL BUFFER RESPONSE ; BLOOD-FLOW ; DYNAMIC CT ; PORTAL-HYPERTENSION ; FIBROSIS ; CIRRHOSIS ; RAT ; TOMOGRAPHY ; DIAGNOSIS ; PRESSURE
英文摘要

In the study described here, we introduced a new ratio acquired with contrast-enhanced ultrasonography (CEUS): a liver parenchyma blood supply ratio that differentiates arterial and portal phases. Our purpose was to determine whether this ratio and other liver parenchyma perfusion parameters acquired with CEUS can be correlated with the severity of chronic liver disease. Twelve patients with non-cirrhotic chronic liver disease, 35 patients with cirrhosis (child class A: n=10; child class B: n=13; child class C: n=12) and 21 healthy volunteers were examined by CEUS. Time-intensity curves were drawn for regions of interest located in liver parenchyma and right kidney cortex using QLAB quantification software. The arterial and portal phases were differentiated by the time to the maximum enhancement of right kidney and liver parenchyma perfusion data acquired from the time-intensity curves: the intensity of liver parenchyma perfused by hepatic arterial flow (I-ap), the intensity of total perfusion of liver parenchyma (I-peak), the intensity of liver parenchyma perfused by portal venous flow (I-pp) and the ratio of portal perfusion to total perfusion of liver parenchyma expressed by the parameters I-pp/I-peak, I-peak, I-pp and I-pp/I-peak significantly decreased in patients with cirrhosis and in patients with non-cirrhotic chronic liver disease, whereas I-ap increased. The parameters I-pp, I-peak, I-pp/I-peak and I-ap correlated with the severity of chronic liver disease (r = -0.938, p < 0.001; r = -0.790, p < 0.001; r = -0.931 p < 0.001; r = 0.31, p < 0.05). The diagnostic accuracy rates for cirrhosis expressed as areas under receiver operating characteristic curves were 0.93 for I-peak, 0.98 for I-pp, 0.98 for I-pp/I-peak, and 0.69 for I-ap. Liver parenchyma perfusion parameters obtained by CEUS were correlated with the severity of chronic liver disease and have the potential to assess cirrhosis non-invasively. (C) 2014 World Federation for Ultrasound in Medicine & Biology.

语种英语
WOS记录号WOS:000343144900002
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62392
专题北京大学第三临床医学院_超声诊断科
作者单位1.Peking Univ, Hosp 3, Dept Ultrasound, Beijing, Peoples R China
2.Capital Med Univ, Beijing Friendship Hosp, Dept Ultrasound, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Liu, Dong,Qian, Linxue,Wang, Jinrui,et al. HEPATIC PERFUSION PARAMETERS OF CONTRAST-ENHANCED ULTRASONOGRAPHY CORRELATE WITH THE SEVERITY OF CHRONIC LIVER DISEASE[J]. ULTRASOUND IN MEDICINE AND BIOLOGY,2014,40(11):2556-2563.
APA Liu, Dong,Qian, Linxue,Wang, Jinrui,Hu, Xiangdong,&Qiu, Lanyan.(2014).HEPATIC PERFUSION PARAMETERS OF CONTRAST-ENHANCED ULTRASONOGRAPHY CORRELATE WITH THE SEVERITY OF CHRONIC LIVER DISEASE.ULTRASOUND IN MEDICINE AND BIOLOGY,40(11),2556-2563.
MLA Liu, Dong,et al."HEPATIC PERFUSION PARAMETERS OF CONTRAST-ENHANCED ULTRASONOGRAPHY CORRELATE WITH THE SEVERITY OF CHRONIC LIVER DISEASE".ULTRASOUND IN MEDICINE AND BIOLOGY 40.11(2014):2556-2563.
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