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IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科  > 期刊论文
学科主题: 临床医学
题名:
HEPATIC PERFUSION PARAMETERS OF CONTRAST-ENHANCED ULTRASONOGRAPHY CORRELATE WITH THE SEVERITY OF CHRONIC LIVER DISEASE
作者: Liu, Dong1; Qian, Linxue1; Wang, Jinrui2; Hu, Xiangdong1; Qiu, Lanyan1
关键词: Contrast-enhanced ultrasonography ; Cirrhosis ; Hepatic perfusion
刊名: ULTRASOUND IN MEDICINE AND BIOLOGY
发表日期: 2014-11-01
DOI: 10.1016/j.ultrasmedbio.2014.05.011
卷: 40, 期:11, 页:2556-2563
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: ARTERIAL BUFFER RESPONSE ; BLOOD-FLOW ; DYNAMIC CT ; PORTAL-HYPERTENSION ; FIBROSIS ; CIRRHOSIS ; RAT ; TOMOGRAPHY ; DIAGNOSIS ; PRESSURE
英文摘要:

In the study described here, we introduced a new ratio acquired with contrast-enhanced ultrasonography (CEUS): a liver parenchyma blood supply ratio that differentiates arterial and portal phases. Our purpose was to determine whether this ratio and other liver parenchyma perfusion parameters acquired with CEUS can be correlated with the severity of chronic liver disease. Twelve patients with non-cirrhotic chronic liver disease, 35 patients with cirrhosis (child class A: n=10; child class B: n=13; child class C: n=12) and 21 healthy volunteers were examined by CEUS. Time-intensity curves were drawn for regions of interest located in liver parenchyma and right kidney cortex using QLAB quantification software. The arterial and portal phases were differentiated by the time to the maximum enhancement of right kidney and liver parenchyma perfusion data acquired from the time-intensity curves: the intensity of liver parenchyma perfused by hepatic arterial flow (I-ap), the intensity of total perfusion of liver parenchyma (I-peak), the intensity of liver parenchyma perfused by portal venous flow (I-pp) and the ratio of portal perfusion to total perfusion of liver parenchyma expressed by the parameters I-pp/I-peak, I-peak, I-pp and I-pp/I-peak significantly decreased in patients with cirrhosis and in patients with non-cirrhotic chronic liver disease, whereas I-ap increased. The parameters I-pp, I-peak, I-pp/I-peak and I-ap correlated with the severity of chronic liver disease (r = -0.938, p < 0.001; r = -0.790, p < 0.001; r = -0.931 p < 0.001; r = 0.31, p < 0.05). The diagnostic accuracy rates for cirrhosis expressed as areas under receiver operating characteristic curves were 0.93 for I-peak, 0.98 for I-pp, 0.98 for I-pp/I-peak, and 0.69 for I-ap. Liver parenchyma perfusion parameters obtained by CEUS were correlated with the severity of chronic liver disease and have the potential to assess cirrhosis non-invasively. (C) 2014 World Federation for Ultrasound in Medicine & Biology.

语种: 英语
WOS记录号: WOS:000343144900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62392
Appears in Collections:北京大学第三临床医学院_超声诊断科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Ultrasound, Beijing, Peoples R China
2.Capital Med Univ, Beijing Friendship Hosp, Dept Ultrasound, Beijing 100050, Peoples R China

Recommended Citation:
Liu, Dong,Qian, Linxue,Wang, Jinrui,et al. HEPATIC PERFUSION PARAMETERS OF CONTRAST-ENHANCED ULTRASONOGRAPHY CORRELATE WITH THE SEVERITY OF CHRONIC LIVER DISEASE[J]. ULTRASOUND IN MEDICINE AND BIOLOGY,2014,40(11):2556-2563.
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