IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Immunoglobulin gene expression in umbilical cord blood-derived CD34(+) hematopoietic stem/progenitor cells
Liu, Jingfang1; Xia, Miaoran2; Wang, Pingzhang3; Wang, Chong2; Geng, Zihan2; Yin, C. Cameron4; Zhang, Chi2; Qiu, Xiaoyan2,3
关键词CD34(+) hematopoietic stem/progenitor cells Immunoglobulin gene expression V(H)DJ(H) rearrangement
刊名GENE
2016
DOI10.1016/j.gene.2015.08.046
575期:1页:108-117
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]EPITHELIAL CANCER-CELLS ; VARIABLE REGION GENE ; HEAVY-CHAIN GENES ; RECOMBINATION ; REARRANGEMENT ; LOCALIZATION ; SEGMENTS ; LEUKEMIA ; KAPPA ; LINES
英文摘要

Recently, immunoglobulin (Ig) expression was reported in a variety of non-B lineage cells, including myeloid cells. We assessed whether hematopoietic stem/progenitor cells (HSC/HPCs) can express Ig. With Gene Expression Omnibus (GEO) microarray database analysis, we found that IGHM was expressed with the highest frequency and level in umbilical cord blood CD34(+) HSC/HPCs, followed by IGK@, IGHE, IGHD, IGHG1, and IGHAL while IGL@ was nearly not expressed. Ig expression was further confirmed by molecular experiments and immunofluorescence. Moreover, HSC/HPCs-derived Ig displayed restricted/biased usages and VHDJH rearrangement patterns. These results suggest that Igs, especially IgM, may have a role in CD34(+) HSC/HPCs function. (C) 2015 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000366226900014
项目编号9122910 ; 81320108020
资助机构National Nature Science Foundation of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62393
专题北京大学基础医学院_免疫学系
北京大学基础医学院
作者单位1.Jishuitan Hosp, Dept Obstet, Beijing 100035, Peoples R China
2.Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China
4.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Liu, Jingfang,Xia, Miaoran,Wang, Pingzhang,et al. Immunoglobulin gene expression in umbilical cord blood-derived CD34(+) hematopoietic stem/progenitor cells[J]. GENE,2016,575(1):108-117.
APA Liu, Jingfang.,Xia, Miaoran.,Wang, Pingzhang.,Wang, Chong.,Geng, Zihan.,...&Qiu, Xiaoyan.(2016).Immunoglobulin gene expression in umbilical cord blood-derived CD34(+) hematopoietic stem/progenitor cells.GENE,575(1),108-117.
MLA Liu, Jingfang,et al."Immunoglobulin gene expression in umbilical cord blood-derived CD34(+) hematopoietic stem/progenitor cells".GENE 575.1(2016):108-117.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
1-s2.0-S037811191501(2168KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Jingfang]的文章
[Xia, Miaoran]的文章
[Wang, Pingzhang]的文章
百度学术
百度学术中相似的文章
[Liu, Jingfang]的文章
[Xia, Miaoran]的文章
[Wang, Pingzhang]的文章
必应学术
必应学术中相似的文章
[Liu, Jingfang]的文章
[Xia, Miaoran]的文章
[Wang, Pingzhang]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 1-s2.0-S0378111915010161-main.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。