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学科主题: 基础医学
题名:
Immunoglobulin gene expression in umbilical cord blood-derived CD34(+) hematopoietic stem/progenitor cells
作者: Liu, Jingfang1; Xia, Miaoran2; Wang, Pingzhang3; Wang, Chong2; Geng, Zihan2; Yin, C. Cameron4; Zhang, Chi2; Qiu, Xiaoyan2,3
关键词: CD34(+) hematopoietic stem/progenitor cells ; Immunoglobulin gene expression ; V(H)DJ(H) rearrangement
刊名: GENE
发表日期: 2016
DOI: 10.1016/j.gene.2015.08.046
卷: 575, 期:1, 页:108-117
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: EPITHELIAL CANCER-CELLS ; VARIABLE REGION GENE ; HEAVY-CHAIN GENES ; RECOMBINATION ; REARRANGEMENT ; LOCALIZATION ; SEGMENTS ; LEUKEMIA ; KAPPA ; LINES
英文摘要:

Recently, immunoglobulin (Ig) expression was reported in a variety of non-B lineage cells, including myeloid cells. We assessed whether hematopoietic stem/progenitor cells (HSC/HPCs) can express Ig. With Gene Expression Omnibus (GEO) microarray database analysis, we found that IGHM was expressed with the highest frequency and level in umbilical cord blood CD34(+) HSC/HPCs, followed by IGK@, IGHE, IGHD, IGHG1, and IGHAL while IGL@ was nearly not expressed. Ig expression was further confirmed by molecular experiments and immunofluorescence. Moreover, HSC/HPCs-derived Ig displayed restricted/biased usages and VHDJH rearrangement patterns. These results suggest that Igs, especially IgM, may have a role in CD34(+) HSC/HPCs function. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 9122910 ; 81320108020
项目资助者: National Nature Science Foundation of China
WOS记录号: WOS:000366226900014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62393
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Jishuitan Hosp, Dept Obstet, Beijing 100035, Peoples R China
2.Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China
4.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

Recommended Citation:
Liu, Jingfang,Xia, Miaoran,Wang, Pingzhang,et al. Immunoglobulin gene expression in umbilical cord blood-derived CD34(+) hematopoietic stem/progenitor cells[J]. GENE,2016,575(1):108-117.
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