北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener′s granulomatosis
作者: Chen, Min; Yu, Feng; Wang, Su-Xia; Zou, Wan-Zhong; Zhang, Ying; Zhao, Ming-Hui; Wang, Hai-Yan
关键词: ANCA ; myeloperoxidase ; vasculitis ; Wegener&prime ; s granulomatosis
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2007
DOI: 10.1093/ndt/gfl509
卷: 22, 期:1, 页:139-145
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
关键词[WOS]: ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES ; IDIOPATHIC SYSTEMIC VASCULITIS ; PATHOLOGICAL CHARACTERISTICS ; ANCA ; MYELOPEROXIDASE ; ASSOCIATION
英文摘要:

Background. Proteinase-3 antineutrophil cytoplasmic antibody (PR3-ANCA) was the serological marker for Wegener′s granulomatosis (WG), while myeloperoxidase (MPO)-ANCA was the serological marker for microscopic polyangiitis (MPA). However, our previous study suggested that patients with MPO-ANCA positive WG were common in Chinese. This study aimed to analyse the renal histology of patients with MPO-ANCA positive WG.

Methods. Patients in our centre with WG were selected according to both the Chapel Hill Consensus Conference (CHCC) definition and American College of Rheumatology classification criteria. Patients with MPA were selected according to the CHCC definition. The renal histology was compared between patients with MPO-ANCA positive WG and with PR3-ANCA positive WG as well as patients with MPO-ANCA positive MPA.

Results. Sixty-one patients with WG had complete renal histological data, 39/61 with positive MPO-ANCA and 22/61 with positive PR3-ANCA. Among patients with crescents in glomeruli, those with MPO-ANCA had fewer cellular crescents and more fibrous crescents than those with PR3-ANCA (P < 0.01 and P < 0.05, respectively). Interstitial fibrosis and tubular atrophy were more prevalent and severe in patients with MPO-ANCA than in those with PR3-ANCA (P < 0.01 and P < 0.05, respectively). Compared with 44 patients with MPO-ANCA positive MPA, patients with MPO-ANCA positive WG had fewer glomeruli with crescents and more normal glomeruli (P < 0.01 and P < 0.01, respectively).

Conclusion. Patients with MPO-ANCA positive WG are common in Chinese. In renal histology, chronic lesions were more severe and prevalent in patients with MPO-ANCA positive WG than in patients with PR3-ANCA positive WG. Glomerular lesions were less severe and less prevalent in patients with MPO-ANCA positive WG than in those with MPO-ANCA positive MPA.

语种: 英语
WOS记录号: WOS:000243497200027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62395
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Renal Div, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Min,Yu, Feng,Wang, Su-Xia,et al. Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener&prime;s granulomatosis[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2007,22(1):139-145.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, Min]'s Articles
[Yu, Feng]'s Articles
[Wang, Su-Xia]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, Min]‘s Articles
[Yu, Feng]‘s Articles
[Wang, Su-Xia]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace