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学科主题临床医学
Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener′s granulomatosis
Chen, Min; Yu, Feng; Wang, Su-Xia; Zou, Wan-Zhong; Zhang, Ying; Zhao, Ming-Hui; Wang, Hai-Yan
关键词ANCA myeloperoxidase vasculitis Wegener&prime s granulomatosis
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2007
DOI10.1093/ndt/gfl509
22期:1页:139-145
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES ; IDIOPATHIC SYSTEMIC VASCULITIS ; PATHOLOGICAL CHARACTERISTICS ; ANCA ; MYELOPEROXIDASE ; ASSOCIATION
英文摘要

Background. Proteinase-3 antineutrophil cytoplasmic antibody (PR3-ANCA) was the serological marker for Wegener′s granulomatosis (WG), while myeloperoxidase (MPO)-ANCA was the serological marker for microscopic polyangiitis (MPA). However, our previous study suggested that patients with MPO-ANCA positive WG were common in Chinese. This study aimed to analyse the renal histology of patients with MPO-ANCA positive WG.

Methods. Patients in our centre with WG were selected according to both the Chapel Hill Consensus Conference (CHCC) definition and American College of Rheumatology classification criteria. Patients with MPA were selected according to the CHCC definition. The renal histology was compared between patients with MPO-ANCA positive WG and with PR3-ANCA positive WG as well as patients with MPO-ANCA positive MPA.

Results. Sixty-one patients with WG had complete renal histological data, 39/61 with positive MPO-ANCA and 22/61 with positive PR3-ANCA. Among patients with crescents in glomeruli, those with MPO-ANCA had fewer cellular crescents and more fibrous crescents than those with PR3-ANCA (P < 0.01 and P < 0.05, respectively). Interstitial fibrosis and tubular atrophy were more prevalent and severe in patients with MPO-ANCA than in those with PR3-ANCA (P < 0.01 and P < 0.05, respectively). Compared with 44 patients with MPO-ANCA positive MPA, patients with MPO-ANCA positive WG had fewer glomeruli with crescents and more normal glomeruli (P < 0.01 and P < 0.01, respectively).

Conclusion. Patients with MPO-ANCA positive WG are common in Chinese. In renal histology, chronic lesions were more severe and prevalent in patients with MPO-ANCA positive WG than in patients with PR3-ANCA positive WG. Glomerular lesions were less severe and less prevalent in patients with MPO-ANCA positive WG than in those with MPO-ANCA positive MPA.

语种英语
WOS记录号WOS:000243497200027
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62395
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Renal Div, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Chen, Min,Yu, Feng,Wang, Su-Xia,et al. Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener&prime;s granulomatosis[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2007,22(1):139-145.
APA Chen, Min.,Yu, Feng.,Wang, Su-Xia.,Zou, Wan-Zhong.,Zhang, Ying.,...&Wang, Hai-Yan.(2007).Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener′s granulomatosis.NEPHROLOGY DIALYSIS TRANSPLANTATION,22(1),139-145.
MLA Chen, Min,et al."Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener′s granulomatosis".NEPHROLOGY DIALYSIS TRANSPLANTATION 22.1(2007):139-145.
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