IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic
Han, Fang1; Faraco, Juliette2; Dong, Xiao Song1; Ollila, Hanna M.2; Lin, Ling2; Li, Jing1; An, Pei1; Wang, Shan3; Jiang, Ke Wei3; Gao, Zhan Cheng1; Zhao, Long1; Yan, Han1; Liu, Ya Nan1; Li, Qing Hua1; Zhang, Xiao Zhe1; Hu, Yan1; Wang, Jing Yu4; Lu, Yun Hui5; Lu, Chang Jun4; Zhou, Wei1; Hallmayer, Joachim2; Huang, Yu Shu6; Strohl, Kingman P.7,8; Pollmaecher, Thomas9; Mignot, Emmanuel2
刊名PLOS GENETICS
2013-10-01
DOI10.1371/journal.pgen.1003880
9期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
资助者National Science Foundation of China ; Sino-German Center for Research Promotion ; Peking-Tsinghua Center for Life Sciences ; Sigrid Juselius Foundation ; National Science Foundation of China ; Sino-German Center for Research Promotion ; Peking-Tsinghua Center for Life Sciences ; Sigrid Juselius Foundation
研究领域[WOS]Genetics & Heredity
关键词[WOS]COMMON VARIANTS ; ETHNIC-GROUPS ; CATAPLEXY ; ONSET ; RISK ; DISEASE ; SUSCEPTIBILITY ; VACCINATION ; POPULATION ; HAPLOTYPES
英文摘要

Previous studies in narcolepsy, an autoimmune disorder affecting hypocretin (orexin) neurons and recently associated with H1N1 influenza, have demonstrated significant associations with five loci. Using a well-characterized Chinese cohort, we refined known associations in TRA@ and P2RY11-DNMT1 and identified new associations in the TCR beta (TRB@; rs9648789 max P = 3.7x10(-9) OR 0.77), ZNF365 (rs10995245 max P = 1.2x10(-11) OR 1.23), and IL10RB-IFNAR1 loci (rs2252931 max P = 2.2x10(-9) OR 0.75). Variants in the Human Leukocyte Antigen (HLA)-DQ region were associated with age of onset (rs7744020 P = 7.9x10(-9) beta -1.9 years) and varied significantly among cases with onset after the 2009 H1N1 influenza pandemic compared to previous years (rs9271117 P = 7.8x10(-10) OR 0.57). These reflected an association of DQB1*03:01 with earlier onset and decreased DQB1*06:02 homozygosity following 2009. Our results illustrate how genetic association can change in the presence of new environmental challenges and suggest that the monitoring of genetic architecture over time may help reveal the appearance of novel triggers for autoimmune diseases.

语种英语
所属项目编号81070 069 ; GZ538 ; NIH-NS23724
资助者National Science Foundation of China ; Sino-German Center for Research Promotion ; Peking-Tsinghua Center for Life Sciences ; Sigrid Juselius Foundation ; National Science Foundation of China ; Sino-German Center for Research Promotion ; Peking-Tsinghua Center for Life Sciences ; Sigrid Juselius Foundation
WOS记录号WOS:000330367200053
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62400
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Pulm, Beijing 100871, Peoples R China
2.Stanford Univ, Ctr Sleep Sci, Palo Alto, CA 94304 USA
3.Peking Univ, Peoples Hosp, Dept Surg, Beijing 100871, Peoples R China
4.Bin Zhou Med Univ, Dept Pulm Med, Yantai, Shandong, Peoples R China
5.Yun Nan Prov Hosp, Dept Pulm Med, Yun Nan, Peoples R China
6.Natl Taiwan Univ, Taipei, Taiwan
7.Case Western Reserve Univ, Dept Med, Div Pulm Crit Care & Sleep Med, Cleveland, OH 44106 USA
8.Cleveland Louis Stokes VA Med Ctr, Cleveland, OH USA
9.Klinikum Ingolstadt, Ctr Mental Hlth, Ingolstadt, Germany
推荐引用方式
GB/T 7714
Han, Fang,Faraco, Juliette,Dong, Xiao Song,et al. Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic[J]. PLOS GENETICS,2013,9(10).
APA Han, Fang.,Faraco, Juliette.,Dong, Xiao Song.,Ollila, Hanna M..,Lin, Ling.,...&Mignot, Emmanuel.(2013).Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic.PLOS GENETICS,9(10).
MLA Han, Fang,et al."Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic".PLOS GENETICS 9.10(2013).
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