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学科主题: 临床医学
题名:
Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic
作者: Han, Fang1; Faraco, Juliette2; Dong, Xiao Song1; Ollila, Hanna M.2; Lin, Ling2; Li, Jing1; An, Pei1; Wang, Shan3; Jiang, Ke Wei3; Gao, Zhan Cheng1; Zhao, Long1; Yan, Han1; Liu, Ya Nan1; Li, Qing Hua1; Zhang, Xiao Zhe1; Hu, Yan1; Wang, Jing Yu4; Lu, Yun Hui5; Lu, Chang Jun4; Zhou, Wei1; Hallmayer, Joachim2; Huang, Yu Shu6; Strohl, Kingman P.7,8; Pollmaecher, Thomas9; Mignot, Emmanuel2
刊名: PLOS GENETICS
发表日期: 2013-10-01
DOI: 10.1371/journal.pgen.1003880
卷: 9, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: COMMON VARIANTS ; ETHNIC-GROUPS ; CATAPLEXY ; ONSET ; RISK ; DISEASE ; SUSCEPTIBILITY ; VACCINATION ; POPULATION ; HAPLOTYPES
英文摘要:

Previous studies in narcolepsy, an autoimmune disorder affecting hypocretin (orexin) neurons and recently associated with H1N1 influenza, have demonstrated significant associations with five loci. Using a well-characterized Chinese cohort, we refined known associations in TRA@ and P2RY11-DNMT1 and identified new associations in the TCR beta (TRB@; rs9648789 max P = 3.7x10(-9) OR 0.77), ZNF365 (rs10995245 max P = 1.2x10(-11) OR 1.23), and IL10RB-IFNAR1 loci (rs2252931 max P = 2.2x10(-9) OR 0.75). Variants in the Human Leukocyte Antigen (HLA)-DQ region were associated with age of onset (rs7744020 P = 7.9x10(-9) beta -1.9 years) and varied significantly among cases with onset after the 2009 H1N1 influenza pandemic compared to previous years (rs9271117 P = 7.8x10(-10) OR 0.57). These reflected an association of DQB1*03:01 with earlier onset and decreased DQB1*06:02 homozygosity following 2009. Our results illustrate how genetic association can change in the presence of new environmental challenges and suggest that the monitoring of genetic architecture over time may help reveal the appearance of novel triggers for autoimmune diseases.

语种: 英语
所属项目编号: 81070 069 ; GZ538 ; NIH-NS23724
项目资助者: National Science Foundation of China ; Sino-German Center for Research Promotion ; Peking-Tsinghua Center for Life Sciences ; Sigrid Juselius Foundation
WOS记录号: WOS:000330367200053
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62400
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Pulm, Beijing 100871, Peoples R China
2.Stanford Univ, Ctr Sleep Sci, Palo Alto, CA 94304 USA
3.Peking Univ, Peoples Hosp, Dept Surg, Beijing 100871, Peoples R China
4.Bin Zhou Med Univ, Dept Pulm Med, Yantai, Shandong, Peoples R China
5.Yun Nan Prov Hosp, Dept Pulm Med, Yun Nan, Peoples R China
6.Natl Taiwan Univ, Taipei, Taiwan
7.Case Western Reserve Univ, Dept Med, Div Pulm Crit Care & Sleep Med, Cleveland, OH 44106 USA
8.Cleveland Louis Stokes VA Med Ctr, Cleveland, OH USA
9.Klinikum Ingolstadt, Ctr Mental Hlth, Ingolstadt, Germany

Recommended Citation:
Han, Fang,Faraco, Juliette,Dong, Xiao Song,et al. Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic[J]. PLOS GENETICS,2013,9(10).
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