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学科主题: 药学
题名:
Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats
作者: Li, Ming-Guang; Lu, Wan-Liang; Wang, Han-Cheng; Zhang, Xuan; Wang, Xue-Qing; Zheng, Ai-Ping; Zhang, Qiang
关键词: insulin ; nanoparticles ; fluorescein isothiocyanate ; hydropropylmethylcellulose ; gastrointestinal distribution
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2007-02-01
DOI: 10.1016/j.ijpharm.2006.08.040
卷: 329, 期:1-2, 页:182-191
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PH-SENSITIVE NANOPARTICLES ; GASTROINTESTINAL-TRACT ; BIOADHESIVE PROPERTIES ; PVM/MA NANOPARTICLES ; DRUG-DELIVERY ; IN-VITRO ; ABSORPTION ; VISCOSITY ; PROTEINS ; CHITOSAN
英文摘要:

The purpose of this work was to investigate distribution, transition, bioadhesion and release behaviors of insulin loaded pH-sensitive nanoparticles in the gut of rats, as well as the effects of viscosity agent on them. Insulin was labeled with fluorescein isothiocyanate (FITC). The FITC-insulin solution and FITC-insulin nanoparticle aqueous dispersions with or without hydropropylmethylcellulose (HPMC, 0.2%, 0.4%, or 0.8% (w/v)) were orally administered to rats, respectively. The amounts of FITC-insulin in both the lumen content and the intestinal mucosa were quantified by a spectrofluorimeter. The release profiles in the gut were plotted by the percentages of FITC-insulin released versus time. FITC-insulin nanoparticle aqueous dispersion showed similar stomach but lower intestine empty rates, and enhanced intestinal mucosa adhesion in comparison with FITC-insulin solution. Addition of the HPMC reduced the stomach and intestine empty rates, enhanced the adhesion of FITC-insulin to the intestine mucosa. The release of FITC-insulin from nanoparticles in the gut showed an S-shape profile, and addition of HPMC prolonged the release half-life from 0.77 to 1.51 h. It was concluded that the behaviors of pH-sensitive nanoparticles tested in gastrointestinal tract of rats and the addition of HPMC were favorable to the absorption of the drug loaded. (c) 2006 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000243773700024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62402
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Li, Ming-Guang,Lu, Wan-Liang,Wang, Han-Cheng,et al. Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2007,329(1-2):182-191.
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