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Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats
Li, Ming-Guang; Lu, Wan-Liang; Wang, Han-Cheng; Zhang, Xuan; Wang, Xue-Qing; Zheng, Ai-Ping; Zhang, Qiang
关键词insulin nanoparticles fluorescein isothiocyanate hydropropylmethylcellulose gastrointestinal distribution
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2007-02-01
DOI10.1016/j.ijpharm.2006.08.040
329期:1-2页:182-191
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PH-SENSITIVE NANOPARTICLES ; GASTROINTESTINAL-TRACT ; BIOADHESIVE PROPERTIES ; PVM/MA NANOPARTICLES ; DRUG-DELIVERY ; IN-VITRO ; ABSORPTION ; VISCOSITY ; PROTEINS ; CHITOSAN
英文摘要

The purpose of this work was to investigate distribution, transition, bioadhesion and release behaviors of insulin loaded pH-sensitive nanoparticles in the gut of rats, as well as the effects of viscosity agent on them. Insulin was labeled with fluorescein isothiocyanate (FITC). The FITC-insulin solution and FITC-insulin nanoparticle aqueous dispersions with or without hydropropylmethylcellulose (HPMC, 0.2%, 0.4%, or 0.8% (w/v)) were orally administered to rats, respectively. The amounts of FITC-insulin in both the lumen content and the intestinal mucosa were quantified by a spectrofluorimeter. The release profiles in the gut were plotted by the percentages of FITC-insulin released versus time. FITC-insulin nanoparticle aqueous dispersion showed similar stomach but lower intestine empty rates, and enhanced intestinal mucosa adhesion in comparison with FITC-insulin solution. Addition of the HPMC reduced the stomach and intestine empty rates, enhanced the adhesion of FITC-insulin to the intestine mucosa. The release of FITC-insulin from nanoparticles in the gut showed an S-shape profile, and addition of HPMC prolonged the release half-life from 0.77 to 1.51 h. It was concluded that the behaviors of pH-sensitive nanoparticles tested in gastrointestinal tract of rats and the addition of HPMC were favorable to the absorption of the drug loaded. (c) 2006 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000243773700024
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62402
专题北京大学药学院
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Li, Ming-Guang,Lu, Wan-Liang,Wang, Han-Cheng,et al. Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2007,329(1-2):182-191.
APA Li, Ming-Guang.,Lu, Wan-Liang.,Wang, Han-Cheng.,Zhang, Xuan.,Wang, Xue-Qing.,...&Zhang, Qiang.(2007).Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats.INTERNATIONAL JOURNAL OF PHARMACEUTICS,329(1-2),182-191.
MLA Li, Ming-Guang,et al."Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats".INTERNATIONAL JOURNAL OF PHARMACEUTICS 329.1-2(2007):182-191.
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