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学科主题: 临床医学
题名:
Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients
作者: Lu, Hai-Ying; Zhuang, Li-Wei; Yu, Yan-Yan; Ivan, Hadad; Si, Chong-Wen; Zeng, Zheng; Li, Jun; Hou, Dong-Ming; Chen, Xin-Yue; Han, Zhong-Hou; Chen, Yong
关键词: intrahepatic HBV DNA ; histology ; antiviral therapy ; HBV genotype
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2007-05-28
卷: 13, 期:20, 页:2878-2882
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INTERFERON TREATMENT ; ADEFOVIR DIPIVOXIL ; PRECORE MUTATIONS ; VIRUS GENOTYPES ; CORE PROMOTER ; LAMIVUDINE ; INFECTION ; COMBINATION ; ENTECAVIR ; THERAPY
英文摘要:

AIM: To evaluate the effect of antiviral agents on intrahepatic HBV DNA in HBeAg-positive chronic hepatitis B patients.

METHODS: Seventy-one patients received treatment with lamivudine, interferon alpha (IFN-alpha 2b) or sequential therapy with lamivudine-IFN-alpha 2b for 48 wk. All subjects were followed up for 24 wk. Serum and intrahepatic HBV DNA were measured quantitatively by PCR. HBV genotypes were analyzed by PCR-RFLP.

RESULTS: At the end of treatment, the intrahepatic HBV DNA level in 71 patients decreased from a mean of (6.1 +/- 1.0) log10 to (4.9 +/- 1.4) log10. Further, a larger decrease was seen in the intrahepatic HBV DNA level in patients with HBeAg seroconversion. Intrahepatic HBV DNA level (before and after treatment) was not significantly affected by the patients′ HBV genotype, or by the probability of virological flare after treatment.

CONCLUSION: Intrahepatic HBV DNA can be effectively lowered by antiviral agents and is a significant marker for monitoring antivirus treatment. Low intrahepatic HBV DNA level may achieve better efficacy of antivirus treatment. (c) 2007 The WJG Press. All rights reserved.

语种: 英语
WOS记录号: WOS:000247325000018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62404
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Huaian Infect Dis Hosp, Huaian 223300, Peoples R China
2.Peking Univ First Hosp, Dept Infect Dis, Beijing 100034, Peoples R China
3.Indiana Univ, Sch Med, Indianapolis, IN 46202 USA
4.Beijing Youan Hosp, Beijing 100054, Peoples R China
5.Qinhuangdao Third Hosp, Qinhuangdao 066000, Hebei Province, Peoples R China

Recommended Citation:
Lu, Hai-Ying,Zhuang, Li-Wei,Yu, Yan-Yan,et al. Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2007,13(20):2878-2882.
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