IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科
学科主题临床医学
Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients
Lu, Hai-Ying; Zhuang, Li-Wei; Yu, Yan-Yan; Ivan, Hadad; Si, Chong-Wen; Zeng, Zheng; Li, Jun; Hou, Dong-Ming; Chen, Xin-Yue; Han, Zhong-Hou; Chen, Yong
关键词intrahepatic HBV DNA histology antiviral therapy HBV genotype
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2007-05-28
13期:20页:2878-2882
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]INTERFERON TREATMENT ; ADEFOVIR DIPIVOXIL ; PRECORE MUTATIONS ; VIRUS GENOTYPES ; CORE PROMOTER ; LAMIVUDINE ; INFECTION ; COMBINATION ; ENTECAVIR ; THERAPY
英文摘要

AIM: To evaluate the effect of antiviral agents on intrahepatic HBV DNA in HBeAg-positive chronic hepatitis B patients.

METHODS: Seventy-one patients received treatment with lamivudine, interferon alpha (IFN-alpha 2b) or sequential therapy with lamivudine-IFN-alpha 2b for 48 wk. All subjects were followed up for 24 wk. Serum and intrahepatic HBV DNA were measured quantitatively by PCR. HBV genotypes were analyzed by PCR-RFLP.

RESULTS: At the end of treatment, the intrahepatic HBV DNA level in 71 patients decreased from a mean of (6.1 +/- 1.0) log10 to (4.9 +/- 1.4) log10. Further, a larger decrease was seen in the intrahepatic HBV DNA level in patients with HBeAg seroconversion. Intrahepatic HBV DNA level (before and after treatment) was not significantly affected by the patients′ HBV genotype, or by the probability of virological flare after treatment.

CONCLUSION: Intrahepatic HBV DNA can be effectively lowered by antiviral agents and is a significant marker for monitoring antivirus treatment. Low intrahepatic HBV DNA level may achieve better efficacy of antivirus treatment. (c) 2007 The WJG Press. All rights reserved.

语种英语
WOS记录号WOS:000247325000018
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62404
专题北京大学第一临床医学院_感染疾病科
作者单位1.Huaian Infect Dis Hosp, Huaian 223300, Peoples R China
2.Peking Univ First Hosp, Dept Infect Dis, Beijing 100034, Peoples R China
3.Indiana Univ, Sch Med, Indianapolis, IN 46202 USA
4.Beijing Youan Hosp, Beijing 100054, Peoples R China
5.Qinhuangdao Third Hosp, Qinhuangdao 066000, Hebei Province, Peoples R China
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GB/T 7714
Lu, Hai-Ying,Zhuang, Li-Wei,Yu, Yan-Yan,et al. Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2007,13(20):2878-2882.
APA Lu, Hai-Ying.,Zhuang, Li-Wei.,Yu, Yan-Yan.,Ivan, Hadad.,Si, Chong-Wen.,...&Chen, Yong.(2007).Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients.WORLD JOURNAL OF GASTROENTEROLOGY,13(20),2878-2882.
MLA Lu, Hai-Ying,et al."Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients".WORLD JOURNAL OF GASTROENTEROLOGY 13.20(2007):2878-2882.
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