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学科主题: 临床医学
题名:
The myeloperoxidase-463G/A polymorphism and coronary artery disease risk: A meta-analysis of 1938 cases and 1990 controls
作者: Chang, Cuixian1; Gao, Baorong2; Liu, Zheng1; Mao, Jianbin1; Jiang, Guoqiang1
关键词: Myeloperoxidase ; Polymorphism ; Coronary artery disease ; Atherosclerosis ; Meta-analysis
刊名: CLINICAL BIOCHEMISTRY
发表日期: 2013-11-01
DOI: 10.1016/j.clinbiochem.2013.09.002
卷: 46, 期:16-17, 页:1644-1648
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: MYOCARDIAL-INFARCTION ; HEALTHY-INDIVIDUALS ; LUNG-CANCER ; POPULATION ; ATHEROSCLEROSIS ; ASSOCIATION ; GENE
英文摘要:

Objectives: Genetic polymorphism of human myeloperoxidase (MPO) -463G/A has been implicated to alter the risk of coronary artery disease (CAD), but the results are controversial. To improve the reliability of the conflicting results, we conducted a meta-analysis of studies relating the MPO -463G/A polymorphism with the risk of CAD.

Design and methods: Two investigators independently searched the MEDLINE, EMBASE and Cochrane Library up to June, 2012. Summary odds ratios (OR) and 95% confidence interval (Cl) for the MPO -463G/A polymorphism and CAD risk were calculated, and potential sources of heterogeneity and publication bias were explored. Statistical analysis was performed with the software program of Stata 9.0.

Results:,5 case-control studies were finally identified for analyses, involving 1938 cases with CAD and 1990 controls. We found that the MPO -463G/A polymorphism has no significant association with overall CAD risk (GIG vs A/A: OR = 0.595, 95%CI = 0.298-1.188, P = 0.141; GIG vs G/A + A/A: OR = 0.886, 95%CI = 0.779-1.008, P = 0.066; G/G + G/A vs A/A: OR = 0.611, 95%CI = 0.334-1.119, P = 0.111; OR = 0.886, 95%CI = 0.779-1.008, P = 0.066; G vs A: OR = 0.843, 95%CI = 0.675-1.053, P = 0.133). The heterogeneity test showed that there were significant differences between individual studies in additive, recessive and allelic genetic models (P = 0.008, P = 0.021, P = 0.019, respectively); further analyses revealed that age and sex possibly account for the heterogeneity.

Conclusions: Our meta-analysis demonstrated the evidence that there was no significant association between the MPO -463G/A polymorphism and the risk of CAD; larger and well-designed multicenter studies are needed to confirm our results. (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000326362100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62405
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.CAPF, Sichuan Prov Hosp, Dept Cardiol, Leshan 614000, Peoples R China
2.Peking Univ, Peoples Hosp, Mol & Genet Unit, Dept Obstet & Gynecol, Beijing 100871, Peoples R China

Recommended Citation:
Chang, Cuixian,Gao, Baorong,Liu, Zheng,et al. The myeloperoxidase-463G/A polymorphism and coronary artery disease risk: A meta-analysis of 1938 cases and 1990 controls[J]. CLINICAL BIOCHEMISTRY,2013,46(16-17):1644-1648.
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