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学科主题口腔医学
Identification of multipotent stem cells from adult dog periodontal ligament
Wang, Wen-Jun; Zhao, Yu-Ming; Lin, Bi-Chen; Yang, Jie; Ge, Li-Hong
关键词canine periodontal ligament stem cells clonogenic capability multidifferentiation potential periodontal regeneration
刊名EUROPEAN JOURNAL OF ORAL SCIENCES
2012-08-01
DOI10.1111/j.1600-0722.2012.00975.x
120期:4页:303-310
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]MARROW STROMAL CELLS ; MESENCHYMAL PROGENITOR CELLS ; SMOOTH MUSCLE ACTIN ; HUMAN BONE-MARROW ; IN-VITRO ; DENTAL-PULP ; EXTRACELLULAR-MATRIX ; DIFFERENTIATION ; REGENERATION ; VIVO
英文摘要

Periodontal diseases, which are characterized by destruction of the connective tissues responsible for restraining the teeth within the jaw, are the main cause of tooth loss. Periodontal regeneration mediated by human periodontal ligament stem cells (hPDLSCs) may offer an alternative strategy for the treatment of periodontal disease. Dogs are a widely used large-animal model for the study of periodontal-disease progression, tissue regeneration, and dental implants, but little attention has been paid to the identification of the cells involved in this species. This study aimed to characterize stem cells isolated from canine periodontal ligament (cPDLSCs). The cPDLSCs, like hPDLSCs, showed clonogenic capability and expressed the mesenchymal stem cell markers STRO-1, CD146, and CD105, but not CD34. After induction of osteogenesis, cPDLSCs showed calcium accumulation in vitro. Moreover, cPDLSCs also showed both adipogenic and chondrogenic potential. Compared with cell-free controls, more cementum/periodontal ligament-like structures were observed in CB-17/SCID mice into which cPDLSCs had been transplanted. These results suggest that cPDLSCs are clonogenic, highly proliferative, and have multidifferentiation potential, and that they could be used as a new cellular therapeutic approach to facilitate successful and more predictable regeneration of periodontal tissue using a canine model of periodontal disease.

语种英语
WOS记录号WOS:000306650300006
项目编号81170928 ; 81141011
资助机构National Natural Science Foundation of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62409
专题北京大学口腔医学院_儿童口腔科
北京大学口腔医学院_第一门诊部
作者单位Peking Univ, Sch & Hosp Stomatol, Dept Pediat Dent, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Wen-Jun,Zhao, Yu-Ming,Lin, Bi-Chen,et al. Identification of multipotent stem cells from adult dog periodontal ligament[J]. EUROPEAN JOURNAL OF ORAL SCIENCES,2012,120(4):303-310.
APA Wang, Wen-Jun,Zhao, Yu-Ming,Lin, Bi-Chen,Yang, Jie,&Ge, Li-Hong.(2012).Identification of multipotent stem cells from adult dog periodontal ligament.EUROPEAN JOURNAL OF ORAL SCIENCES,120(4),303-310.
MLA Wang, Wen-Jun,et al."Identification of multipotent stem cells from adult dog periodontal ligament".EUROPEAN JOURNAL OF ORAL SCIENCES 120.4(2012):303-310.
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