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学科主题临床医学
Distinguishing malignant from normal stomach tissues and its in vivo, in situ measurement in operating process using FTIR Fiber-Optic techniques
Xu, YZ; Yang, LM; Xu, Z; Zhao, Y; Ling, XF; Li, OB; Wang, JS; Zhang, NW; Zhang, YF; Wu, JG
关键词FTIR Fiber-Optics stomach tissues cancer diagnosis
刊名SCIENCE IN CHINA SERIES B-CHEMISTRY
2005-04-01
DOI10.1360/04yb0135
48期:2页:167-175
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]TRANSFORM INFRARED MICROSCOPY ; RAMAN-SPECTROSCOPY ; CANCER
英文摘要

Gastric tissue samples were studied using mid-IR fiber-optic attenuated total reflectance (ATR) spectroscopy. FTIR spectra of 90 tissue samples from 48 patients, including 32 normal and 58 malignant tissue samples, were chosen as examples. Malignancy was usually characterized by the absence of CH and C=O bands, a weak amide II band near 1545 cm(-1), a shift of the amide I band to lower wave number, a decrease in the similar to 1450 cm(-1) peak to less than the similar to 1400 cm(-1) peak. Subtraction spectra indicate that the amide I and amide II bands of normal and malignant tissues have larger differences in peak positions and relative intensities. The statistical analysis results confirm this conclusion. The results indicate that FTIR fiber optic techniques provide important information about cancerous tissue of the stomach, which can be used to differentiate the malignant tissue from the normal tissue. Based on the above results we successfully realize the detection of the tumor tissues of digestive tract in vivo and in situ. And the results of detection cancer near operating room and in vivo and in situ in the operating room are consistent with the conclusions for the samples stored in liquid N-2, which is the basis for the clinical application.

语种英语
WOS记录号WOS:000229230700011
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62421
专题北京大学第三临床医学院_普通外科
作者单位1.Peking Univ, Hosp 3, Dept Surg, Beijing 100083, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, State Key lab Rare Earth Mat & Applicat, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
4.Xian Jiaotong Univ, Hosp 1, Dept Oncol, Xian 710061, Peoples R China
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GB/T 7714
Xu, YZ,Yang, LM,Xu, Z,et al. Distinguishing malignant from normal stomach tissues and its in vivo, in situ measurement in operating process using FTIR Fiber-Optic techniques[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2005,48(2):167-175.
APA Xu, YZ.,Yang, LM.,Xu, Z.,Zhao, Y.,Ling, XF.,...&Wu, JG.(2005).Distinguishing malignant from normal stomach tissues and its in vivo, in situ measurement in operating process using FTIR Fiber-Optic techniques.SCIENCE IN CHINA SERIES B-CHEMISTRY,48(2),167-175.
MLA Xu, YZ,et al."Distinguishing malignant from normal stomach tissues and its in vivo, in situ measurement in operating process using FTIR Fiber-Optic techniques".SCIENCE IN CHINA SERIES B-CHEMISTRY 48.2(2005):167-175.
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