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学科主题: 临床医学
题名:
Clinical features and management of postural tachycardia syndrome in children: a single-center experience
作者: Li Jiawei1; Zhang Qingyou1; Hao Hongjun2; Jin Hongfang1; Du Junbao1
关键词: postural tachycardia syndrome ; children ; orthostatic intolerance
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-11-05
DOI: 10.3760/cma.j.issn.0366-6999.20140244
卷: 127, 期:21, 页:3684-3689
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MIDODRINE HYDROCHLORIDE ; ADOLESCENTS ; DIAGNOSIS ; SYNCOPE
英文摘要:

Background The incidence of postural tachycardia syndrome (POTS) has been increasing in children and adolescents, while clinical characteristics of POTS in the pediatric population are not fully understood.

Methods An observational study was performed in 150 pediatric patients aged between 5 and 18 years who underwent head-up tilt test (HUTT) with the diagnosis of POTS at Peking University First Hospital from March 2008 to August 2013. Demographic data, clinical presentation, autonomic parameters, laboratory findings, and treatments were recorded.

Results POTS in children commonly occurred in the age of 7-14 years. Dizziness (84.00%) was the most common symptom, followed by weakness (72.00%) and orthostatic syncope (62.67%). Positive family history of orthostatic intolerance (01) was found in 24.64% of children with POTS. And 33.09% of them had preceding infection history as precipitating events. Ten percent of them suffered from orthostatic hypertension. Hyperadrenergic status was documented in 51.28% of 39 patients who were tested for the standing norepinephrine levels. More than half of POTS patients, with 24-hour urinary sodium level <124 mrno1/24 hours, were suitable for treatment of salt supplementation. At least 25.74% of POTS patients were of positive acetylcholine receptor (AChR) antibody. Low iron storage in children with POTS was relatively rare. Most patients responded well to treatments, 43.51% of patients recovered, while 7.63% of them had relapse after symptoms disappeared.

Conclusions POTS is a relatively common condition with complex pathophysiology and heterogeneous clinical manifestation. A comprehensive therapeutic regimen is recommended for the treatment.

语种: 英语
所属项目编号: Z121107001012051
项目资助者: Beijing Committee of Science and Technology, China
WOS记录号: WOS:000346329300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62423
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China

Recommended Citation:
Li Jiawei,Zhang Qingyou,Hao Hongjun,et al. Clinical features and management of postural tachycardia syndrome in children: a single-center experience[J]. CHINESE MEDICAL JOURNAL,2014,127(21):3684-3689.
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