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学科主题临床医学
Clinical features and management of postural tachycardia syndrome in children: a single-center experience
Li Jiawei1; Zhang Qingyou1; Hao Hongjun2; Jin Hongfang1; Du Junbao1
关键词postural tachycardia syndrome children orthostatic intolerance
刊名CHINESE MEDICAL JOURNAL
2014-11-05
DOI10.3760/cma.j.issn.0366-6999.20140244
127期:21页:3684-3689
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]MIDODRINE HYDROCHLORIDE ; ADOLESCENTS ; DIAGNOSIS ; SYNCOPE
英文摘要

Background The incidence of postural tachycardia syndrome (POTS) has been increasing in children and adolescents, while clinical characteristics of POTS in the pediatric population are not fully understood.

Methods An observational study was performed in 150 pediatric patients aged between 5 and 18 years who underwent head-up tilt test (HUTT) with the diagnosis of POTS at Peking University First Hospital from March 2008 to August 2013. Demographic data, clinical presentation, autonomic parameters, laboratory findings, and treatments were recorded.

Results POTS in children commonly occurred in the age of 7-14 years. Dizziness (84.00%) was the most common symptom, followed by weakness (72.00%) and orthostatic syncope (62.67%). Positive family history of orthostatic intolerance (01) was found in 24.64% of children with POTS. And 33.09% of them had preceding infection history as precipitating events. Ten percent of them suffered from orthostatic hypertension. Hyperadrenergic status was documented in 51.28% of 39 patients who were tested for the standing norepinephrine levels. More than half of POTS patients, with 24-hour urinary sodium level <124 mrno1/24 hours, were suitable for treatment of salt supplementation. At least 25.74% of POTS patients were of positive acetylcholine receptor (AChR) antibody. Low iron storage in children with POTS was relatively rare. Most patients responded well to treatments, 43.51% of patients recovered, while 7.63% of them had relapse after symptoms disappeared.

Conclusions POTS is a relatively common condition with complex pathophysiology and heterogeneous clinical manifestation. A comprehensive therapeutic regimen is recommended for the treatment.

语种英语
WOS记录号WOS:000346329300002
项目编号Z121107001012051
资助机构Beijing Committee of Science and Technology, China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62423
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Li Jiawei,Zhang Qingyou,Hao Hongjun,et al. Clinical features and management of postural tachycardia syndrome in children: a single-center experience[J]. CHINESE MEDICAL JOURNAL,2014,127(21):3684-3689.
APA Li Jiawei,Zhang Qingyou,Hao Hongjun,Jin Hongfang,&Du Junbao.(2014).Clinical features and management of postural tachycardia syndrome in children: a single-center experience.CHINESE MEDICAL JOURNAL,127(21),3684-3689.
MLA Li Jiawei,et al."Clinical features and management of postural tachycardia syndrome in children: a single-center experience".CHINESE MEDICAL JOURNAL 127.21(2014):3684-3689.
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