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学科主题: 临床医学
题名:
Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target?
作者: Sun, Jian-jun1; Wang, Zhen-yu1; Li, Ling-song2; Yu, Hai-yan3; Xu, Yong-sheng3,4; Wu, Hai-bo5; Luo, Yi1; Liu, Bin1; Zheng, Mei6; Mao, Jin-long7; Lou, Xiao-hui8
关键词: nerve regeneration ; astrocytoma ; mice ; immunodeficiency (BALB/c) mice ; Notch ; nestin ; glial fibrillary acidic protein ; CD133 ; spinal cord ; brain ; MRI ; neural regeneration
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2015-02-01
DOI: 10.4103/1673-5374.152378
卷: 10, 期:2, 页:244-251
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: GLIOMA STEM-CELLS ; ENDOTHELIAL GROWTH-FACTOR ; TUMOR-INITIATING CELLS ; GLIOBLASTOMA CELLS ; DOWN-REGULATION ; BRAIN CANCER ; EXPRESSION ; ACTIVATION ; ANGIOGENESIS ; INHIBITION
英文摘要:

This study was designed to investigate whether the Notch pathway is involved in the development of diffuse spinal cord astrocytomas. BALB/c nude mice received injections of CD133(+) and CD133(-) cell suspensions prepared using human recurrent diffuse spinal cord astrocytoma tissue through administration into the right parietal lobe. After 7-11 weeks, magnetic resonance imaging was performed weekly. Xenografts were observed on the surfaces of the brains of mice receiving the CD133(+) cell suspension, and Notch-immunopositive expression was observed in the xenografts. By contrast, no xenografts appeared in the identical position on the surfaces of the brains of mice receiving the CD133(-) cell suspension, and Notch-immunopositive expression was hardly detected either. Hematoxylin-eosin staining and immunohistochemical staining revealed xenografts on the convex surfaces of the brains of mice that underwent CD133(+) astrocytoma transplantation. Some sporadic astroglioma cells showed pseudopodium-like structures, which extended into the cerebral white matter. However, it should be emphasized that the subcortex xenograft with Notch-immunopositive expression was found in the fourth mouse received injection of CD133(-) astrocytoma cells. However, these findings suggest that the Notch pathway plays an important role in the formation of astrocytomas, and can be considered a novel treatment target for diffuse spinal cord astrocytoma.

语种: 英语
所属项目编号: 200800011035 ; 81200969/H0912
项目资助者: Science Foundation of Ministry of Education of China ; National Natural Science Foundation of China
WOS记录号: WOS:000351783300020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62424
Appears in Collections:北京大学第三临床医学院_神经外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Neurosurg, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, China Stem Cell Res Ctr, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Clin Stem Cell Ctr, Beijing 100871, Peoples R China
4.Logist Coll Chinese Peoples Armed Police Force, Tissue & Cell Res Ctr, Dept Biotech Treatment, Clin Lab, Tianjin, Peoples R China
5.Peking Univ, Hosp 3, Dept Neuroradiol, Beijing 100871, Peoples R China
6.Peking Univ, Hosp 3, Dept Neurol, Beijing 100871, Peoples R China
7.Peking Union Med Coll, Dept Neurosurg, Beijing 100021, Peoples R China
8.Wenzhou Med Univ, Ruian Peoples Hosp, Dept Neurosurg, Wenzhou, Zhejiang, Peoples R China

Recommended Citation:
Sun, Jian-jun,Wang, Zhen-yu,Li, Ling-song,et al. Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target?[J]. NEURAL REGENERATION RESEARCH,2015,10(2):244-251.
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