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Development of RGD-Based Radiotracers for Tumor Imaging and Therapy: Translating from Bench to Bedside
Liu, Z.1,2; Wang, F.1,2
关键词Arg-Gly-Asp (RGD) integrin alpha(v)beta(3) molecular imaging radionuclide therapy radiotracer tumor
刊名CURRENT MOLECULAR MEDICINE
2013-12-01
13期:10页:1487-1505
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; INTEGRIN ALPHA(V)BETA(3) EXPRESSION ; GLIOMA INTEGRIN-ALPHA(V)BETA(3) EXPRESSION ; GLY-ASP PEPTIDE ; CANCER-PATIENTS ; BREAST-CANCER ; ALPHA-V-BETA-3 EXPRESSION ; RADIONUCLIDE THERAPY ; RADIATION-DOSIMETRY ; BOMBESIN HETERODIMER
英文摘要

The cell adhesion molecule integrin alpha(v)beta(3) is an important player in the process of angiogenesis. In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin alpha(v)beta(3) has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) imaging of integrin alpha(v)beta(3) expression. Several promising radiotracers have been tested in clinical trials. In this review, we will introduce strategies that have been used to optimize and accelerate RGD radiotracers towards clinical translation; illustrate RGD-based radiotracers that have been investigated in clinical trials; and discuss the other applications of RGD radiotracers aside from tumor detection.

语种英语
WOS记录号WOS:000327448200002
项目编号81222019 ; 30930030 ; 81000625 ; 30870728 ; 30900373 ; 81028009 ; 81125011 ; 2011CB707703 ; 2013CB733802 ; 2011 YQ030114 ; 2012BAK25B03-16 ; 2012ZX091023 01-018 ; BMU20110263 ; 7132131 ; 7132123 ; Z121107002512010
资助机构National Natural Science Foundation of China (NSFC) ; Outstanding Youth Fund ; "973" projects ; Ministry of Science and Technology of China ; Innovation Team Project of Ministry of Education of China ; Beijing Natural Science Foundation ; Beijing Nova Program
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62427
专题北京大学医药卫生分析中心
作者单位1.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Dept Radiat Med, Sch Basic Med Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liu, Z.,Wang, F.. Development of RGD-Based Radiotracers for Tumor Imaging and Therapy: Translating from Bench to Bedside[J]. CURRENT MOLECULAR MEDICINE,2013,13(10):1487-1505.
APA Liu, Z.,&Wang, F..(2013).Development of RGD-Based Radiotracers for Tumor Imaging and Therapy: Translating from Bench to Bedside.CURRENT MOLECULAR MEDICINE,13(10),1487-1505.
MLA Liu, Z.,et al."Development of RGD-Based Radiotracers for Tumor Imaging and Therapy: Translating from Bench to Bedside".CURRENT MOLECULAR MEDICINE 13.10(2013):1487-1505.
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