北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Lupus nephritis combined with renal injury due to thrombotic thrombocytopaenic purpura-haemolytic uraemic syndrome
作者: Yu, Feng; Tan, Ying; Zhao, Ming-Hui1
关键词: ADAMTS-13 ; haemolytic uraemic syndrome ; lupus nephritis ; thrombotic thrombocytopaenic purpura ; von Wilebrand factor
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2010
DOI: 10.1093/ndt/gfp421
卷: 25, 期:1, 页:145-152
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
关键词[WOS]: VON-WILLEBRAND-FACTOR ; FACTOR-CLEAVING PROTEASE ; ANTIPHOSPHOLIPID SYNDROME NEPHROPATHY ; PLASMA-EXCHANGE ; INTRAVENOUS CYCLOPHOSPHAMIDE ; MYCOPHENOLATE-MOFETIL ; VASCULAR-LESIONS ; DISEASE-ACTIVITY ; ERYTHEMATOSUS ; ADAMTS13
英文摘要:

Methods. Clinical and renal histopathological data of patients with lupus nephritis were reviewed for clinical and pathological evidence of both TTP-HUS and renal thrombotic microangiopathy (TMA). Serum ADAMTS-13 activity and ADAMTS-13 autoantibodies were further studied.

Results. Seven patients with evidence of both TTP-HUS and renal TMA were identified in 353 patients with lupus nephritis. In comparison with 55 patients with lupus nephritis without TTP-HUS, those with TTP-HUS had a higher prevalence of acute renal failure and worse renal outcome. The serum ADAMTS-13 activity was significantly lower in patients with both lupus nephritis and TTP-HUS than in patients with lupus nephritis only and in normal control (40% versus 69%, P = 0.012; 40% versus 81%, P < 0.001, respectively). The prevalence of ADAMTS-13 autoantibodies was significantly higher in patients with both lupus nephritis and TTP-HUS than in patients with lupus nephritis only and in normal control (6/7, 86% versus 10/55, 18%, P < 0.001; 6/7, 86% versus 0, P < 0.001, respectively). After clinical remission, the serum ADAMTS-13 activity of the seven patients with TTP-HUS increased significantly (40% versus 63%, P < 0.001) and five out of the six patients with positive ADAMTS-13 autoantibodies turned negative.

Conclusions. ADAMTS-13 autoantibodies might play an important role in the pathogenesis of TTP-HUS associated with lupus nephritis. The long-term outcome seems to be worse in patients with both TTP-HUS and lupus nephritis than in patients with lupus nephritis alone.

语种: 英语
所属项目编号: 985-2-033-39
项目资助者: Peking University
WOS记录号: WOS:000273113100025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62428
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Peking Univ Hosp 1, Div Renal,Dept Med, Beijing 100034, Peoples R China

Recommended Citation:
Yu, Feng,Tan, Ying,Zhao, Ming-Hui. Lupus nephritis combined with renal injury due to thrombotic thrombocytopaenic purpura-haemolytic uraemic syndrome[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2010,25(1):145-152.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, Feng]'s Articles
[Tan, Ying]'s Articles
[Zhao, Ming-Hui]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, Feng]‘s Articles
[Tan, Ying]‘s Articles
[Zhao, Ming-Hui]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace