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学科主题: 药学
题名:
Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca2+-mobilizing activity in T-lymphocytes
作者: Li, Lingjun1,2; Siebrands, Cornelia C.3; Yang, Zhenjun1; Zhang, Liangren1; Guse, Andreas H.3; Zhang, Lihe1
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
发表日期: 2010
DOI: 10.1039/b925295a
卷: 8, 期:8, 页:1843-1848
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ADENOSINE-DIPHOSPHORIBOSE CADPR ; CALCIUM-RELEASE ; CA2+ RELEASE ; 5&prime ; -DIPHOSPHATE RIBOSE ; 5-DIPHOSPHATE RIBOSE ; CARBOCYCLIC-RIBOSE ; CHEMISTRY ; DERIVATIVES ; POTENT ; 2ND-MESSENGER
英文摘要:

A purine nucleobase-simplified cyclic ADP ribose (cADPR) analogue 6b was synthesized, in which a 1,2,3-triazole-4-amide was constructed, instead of a purine moiety, and the northern ribose was replaced by an ether strand. Compound 6b exhibits calcium release activity in intact T-lymphocytes and indicates that it is a membrane-permeable cADPR mimic. Thus, the cADPR analogue containing 1,2,3-triazole-4-amide provides a novel template for further designing cADPR analogues and elucidating their structure-activity relationships.

语种: 英语
所属项目编号: 90713005 ; 20802017 ; 200800010078 ; GU 360/13-1
项目资助者: National Natural Sciences Foundation of China ; Ministry of Education of China ; Deutsche Forschungsgemeinschaft
WOS记录号: WOS:000276192100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62434
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Henan Normal Univ, Coll Chem & Environm Sci, Xinxiang 453007, Peoples R China
3.Univ Med Ctr Hamburg Eppendorf, Calcium Signaling Grp, Ctr Med Expt, Inst Biochem & Mol Biol Cellular Signal Transduct, D-20246 Hamburg, Germany

Recommended Citation:
Li, Lingjun,Siebrands, Cornelia C.,Yang, Zhenjun,et al. Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca2+-mobilizing activity in T-lymphocytes[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2010,8(8):1843-1848.
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