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Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca2+-mobilizing activity in T-lymphocytes
Li, Lingjun1,2; Siebrands, Cornelia C.3; Yang, Zhenjun1; Zhang, Liangren1; Guse, Andreas H.3; Zhang, Lihe1
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
2010
DOI10.1039/b925295a
8期:8页:1843-1848
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Natural Sciences Foundation of China ; Ministry of Education of China ; Deutsche Forschungsgemeinschaft ; National Natural Sciences Foundation of China ; Ministry of Education of China ; Deutsche Forschungsgemeinschaft
研究领域[WOS]Chemistry
关键词[WOS]ADENOSINE-DIPHOSPHORIBOSE CADPR ; CALCIUM-RELEASE ; CA2+ RELEASE ; 5&prime ; -DIPHOSPHATE RIBOSE ; 5-DIPHOSPHATE RIBOSE ; CARBOCYCLIC-RIBOSE ; CHEMISTRY ; DERIVATIVES ; POTENT ; 2ND-MESSENGER
英文摘要

A purine nucleobase-simplified cyclic ADP ribose (cADPR) analogue 6b was synthesized, in which a 1,2,3-triazole-4-amide was constructed, instead of a purine moiety, and the northern ribose was replaced by an ether strand. Compound 6b exhibits calcium release activity in intact T-lymphocytes and indicates that it is a membrane-permeable cADPR mimic. Thus, the cADPR analogue containing 1,2,3-triazole-4-amide provides a novel template for further designing cADPR analogues and elucidating their structure-activity relationships.

语种英语
所属项目编号90713005 ; 20802017 ; 200800010078 ; GU 360/13-1
资助者National Natural Sciences Foundation of China ; Ministry of Education of China ; Deutsche Forschungsgemeinschaft ; National Natural Sciences Foundation of China ; Ministry of Education of China ; Deutsche Forschungsgemeinschaft
WOS记录号WOS:000276192100015
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62434
Collection北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Henan Normal Univ, Coll Chem & Environm Sci, Xinxiang 453007, Peoples R China
3.Univ Med Ctr Hamburg Eppendorf, Calcium Signaling Grp, Ctr Med Expt, Inst Biochem & Mol Biol Cellular Signal Transduct, D-20246 Hamburg, Germany
Recommended Citation
GB/T 7714
Li, Lingjun,Siebrands, Cornelia C.,Yang, Zhenjun,et al. Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca2+-mobilizing activity in T-lymphocytes[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2010,8(8):1843-1848.
APA Li, Lingjun,Siebrands, Cornelia C.,Yang, Zhenjun,Zhang, Liangren,Guse, Andreas H.,&Zhang, Lihe.(2010).Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca2+-mobilizing activity in T-lymphocytes.ORGANIC & BIOMOLECULAR CHEMISTRY,8(8),1843-1848.
MLA Li, Lingjun,et al."Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca2+-mobilizing activity in T-lymphocytes".ORGANIC & BIOMOLECULAR CHEMISTRY 8.8(2010):1843-1848.
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