北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 心血管所  > 期刊论文
学科主题: 基础医学
题名:
Subtype-specific alpha(1)- and beta-adrenoceptor signaling in the heart
作者: Xiao, RP; Zhu, WZ; Zheng, M; Cao, CM; Zhang, YY; Lakatta, EG; Han, Q
刊名: TRENDS IN PHARMACOLOGICAL SCIENCES
发表日期: 2006-06-01
DOI: 10.1016/j.tips.2006.04.009
卷: 27, 期:6, 页:330-337
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PROTEIN-KINASE-A ; IDIOPATHIC DILATED CARDIOMYOPATHY ; ADRENERGIC-RECEPTOR KINASE ; RAT VENTRICULAR MYOCYTES ; BETA(2)-ADRENERGIC RECEPTOR ; CARDIAC MYOCYTES ; TRANSGENIC MICE ; ADENYLYL-CYCLASE ; BETA(1)-ADRENERGIC RECEPTOR ; ALPHA(1D)-ADRENERGIC RECEPTORS
英文摘要:

Recent studies of adrenoceptors have revealed subtype-specific signaling, promiscuous G-protein coupling, time-dependent switching of intracellular signaling pathways, intermolecular interactions within or between adrenoceptor subfamilies, and G-protein-independent signaling pathways. These findings have extended the classical linear paradigm of G-protein-coupled receptor signaling to a complex ′signalome′ in which an individual adrenoceptor initiates multiple signaling pathways in a temporally and spatially regulated manner. In particular, persistent stimulation of beta-adrenoceptor subtypes causes a time-dependent switch of signaling pathways and elicits different, even opposing, functional roles of these receptors in regulating cardiac structure and function. Recent progress in the understanding of subtype-specific functions and signaling mechanisms of cardiac adrenoceptor subtypes, particularly beta(1)-adrenoceptors, beta(2)-adrenoceptors, alpha(1A)-adrenoceptors and alpha(1B)-adrenoceptors, might have important pathogenic and therapeutic implications for heart disease.

语种: 英语
WOS记录号: WOS:000238793900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62436
Appears in Collections:基础医学院_心血管所_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
1-s2.0-S0165614706001076-main.pdf(175KB)期刊论文作者接受稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
3.NIA, Ctr Gerontol Res, Cardiovasc Sci Lab, NIH, Baltimore, MD 21224 USA

Recommended Citation:
Xiao, RP,Zhu, WZ,Zheng, M,et al. Subtype-specific alpha(1)- and beta-adrenoceptor signaling in the heart[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2006,27(6):330-337.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xiao, RP]'s Articles
[Zhu, WZ]'s Articles
[Zheng, M]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xiao, RP]‘s Articles
[Zhu, WZ]‘s Articles
[Zheng, M]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace