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学科主题: 基础医学
题名:
Subtype-specific alpha(1)- and beta-adrenoceptor signaling in the heart
作者: Xiao, RP; Zhu, WZ; Zheng, M; Cao, CM; Zhang, YY; Lakatta, EG; Han, Q
刊名: TRENDS IN PHARMACOLOGICAL SCIENCES
发表日期: 2006-06-01
DOI: 10.1016/j.tips.2006.04.009
卷: 27, 期:6, 页:330-337
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PROTEIN-KINASE-A ; IDIOPATHIC DILATED CARDIOMYOPATHY ; ADRENERGIC-RECEPTOR KINASE ; RAT VENTRICULAR MYOCYTES ; BETA(2)-ADRENERGIC RECEPTOR ; CARDIAC MYOCYTES ; TRANSGENIC MICE ; ADENYLYL-CYCLASE ; BETA(1)-ADRENERGIC RECEPTOR ; ALPHA(1D)-ADRENERGIC RECEPTORS
英文摘要:

Recent studies of adrenoceptors have revealed subtype-specific signaling, promiscuous G-protein coupling, time-dependent switching of intracellular signaling pathways, intermolecular interactions within or between adrenoceptor subfamilies, and G-protein-independent signaling pathways. These findings have extended the classical linear paradigm of G-protein-coupled receptor signaling to a complex ′signalome′ in which an individual adrenoceptor initiates multiple signaling pathways in a temporally and spatially regulated manner. In particular, persistent stimulation of beta-adrenoceptor subtypes causes a time-dependent switch of signaling pathways and elicits different, even opposing, functional roles of these receptors in regulating cardiac structure and function. Recent progress in the understanding of subtype-specific functions and signaling mechanisms of cardiac adrenoceptor subtypes, particularly beta(1)-adrenoceptors, beta(2)-adrenoceptors, alpha(1A)-adrenoceptors and alpha(1B)-adrenoceptors, might have important pathogenic and therapeutic implications for heart disease.

语种: 英语
WOS记录号: WOS:000238793900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62436
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
3.NIA, Ctr Gerontol Res, Cardiovasc Sci Lab, NIH, Baltimore, MD 21224 USA

Recommended Citation:
Xiao, RP,Zhu, WZ,Zheng, M,et al. Subtype-specific alpha(1)- and beta-adrenoceptor signaling in the heart[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2006,27(6):330-337.
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