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学科主题: 临床医学
题名:
The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance
作者: Xie, Fei1,2,3; Ye, Lin3; Chen, Jinfeng1,2; Wu, Nan1,2; Zhang, Zhiqian1,2; Yang, Yue1,2; Zhang, Lijian1,2; Jiang, Wen G.3
关键词: metastasis suppressor-1 ; MTSS1 ; MIM ; oesophageal squamous cell carcinoma ; metastasis
刊名: JOURNAL OF TRANSLATIONAL MEDICINE
发表日期: 2011-06-22
DOI: 10.1186/1479-5876-9-95
卷: 9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: MISSING-IN-METASTASIS ; CANCER-CELLS ; BREAST-CANCER ; MIM-B ; BLADDER-CANCER ; EXPRESSION ; ACTIN ; PROTEIN ; DOMAIN ; GENE
英文摘要:

Background: Metastasis suppressor-1 (MTSS1) has been proposed to function as a cytoskeletal protein with a role in cancer metastasis. Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers, yet the clinical relevance of MTSS1 in oesophageal squamous cell carcinoma (ESCC) has not been reported.

Methods: In this study, we assessed the expression levels of MTSS1 in tumours and its matched adjacent non-tumour tissues obtained from 105 ESCC patients. We also used ESCC cells with differing MTSS1 expression and assessed the influence of MTSS1 on ESCC cells.

Results: Down-regulation of MTSS1 expression was observed both in oesophageal tumour tissues and ESCC cancer cell lines. We also reported that MTSS1 expression was associated with tumour grade (p = 0.024), lymph node metastasis (p = 0.010) and overall survival (p = 0.035). Patients with high levels of MTSS1 transcripts had a favorable prognosis in comparison with those who had reduced or absent expression levels. Using over-expression and knockdown approach, we created sublines from ESCC cells and further demonstrated that MTSS1 expression in ESCC cells significantly influenced the aggressiveness of the oesophageal cancer cells, by reducing their cellular migration and in vitro invasiveness.

Conclusion: MTSS1 serves as a potential prognostic indicator in human ESCC and may be an important target for cancer therapy.

语种: 英语
项目资助者: Cancer Research Wales ; Albert Hung Foundation ; Cardiff University
WOS记录号: WOS:000292516000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62440
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Beijing Canc Hosp, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Thorac Surg, Beijing 100142, Peoples R China
3.Cardiff Univ, Sch Med, Metastasis & Angiogenesis Res Grp, Cardiff CF14 4XN, S Glam, Wales

Recommended Citation:
Xie, Fei,Ye, Lin,Chen, Jinfeng,et al. The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2011,9.
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