IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance
Xie, Fei1,2,3; Ye, Lin3; Chen, Jinfeng1,2; Wu, Nan1,2; Zhang, Zhiqian1,2; Yang, Yue1,2; Zhang, Lijian1,2; Jiang, Wen G.3
关键词metastasis suppressor-1 MTSS1 MIM oesophageal squamous cell carcinoma metastasis
刊名JOURNAL OF TRANSLATIONAL MEDICINE
2011-06-22
DOI10.1186/1479-5876-9-95
9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
资助者Cancer Research Wales ; Albert Hung Foundation ; Cardiff University ; Cancer Research Wales ; Albert Hung Foundation ; Cardiff University
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]MISSING-IN-METASTASIS ; CANCER-CELLS ; BREAST-CANCER ; MIM-B ; BLADDER-CANCER ; EXPRESSION ; ACTIN ; PROTEIN ; DOMAIN ; GENE
英文摘要

Background: Metastasis suppressor-1 (MTSS1) has been proposed to function as a cytoskeletal protein with a role in cancer metastasis. Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers, yet the clinical relevance of MTSS1 in oesophageal squamous cell carcinoma (ESCC) has not been reported.

Methods: In this study, we assessed the expression levels of MTSS1 in tumours and its matched adjacent non-tumour tissues obtained from 105 ESCC patients. We also used ESCC cells with differing MTSS1 expression and assessed the influence of MTSS1 on ESCC cells.

Results: Down-regulation of MTSS1 expression was observed both in oesophageal tumour tissues and ESCC cancer cell lines. We also reported that MTSS1 expression was associated with tumour grade (p = 0.024), lymph node metastasis (p = 0.010) and overall survival (p = 0.035). Patients with high levels of MTSS1 transcripts had a favorable prognosis in comparison with those who had reduced or absent expression levels. Using over-expression and knockdown approach, we created sublines from ESCC cells and further demonstrated that MTSS1 expression in ESCC cells significantly influenced the aggressiveness of the oesophageal cancer cells, by reducing their cellular migration and in vitro invasiveness.

Conclusion: MTSS1 serves as a potential prognostic indicator in human ESCC and may be an important target for cancer therapy.

语种英语
资助者Cancer Research Wales ; Albert Hung Foundation ; Cardiff University ; Cancer Research Wales ; Albert Hung Foundation ; Cardiff University
WOS记录号WOS:000292516000001
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62440
Collection北京大学临床肿瘤学院
作者单位1.Beijing Canc Hosp, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Thorac Surg, Beijing 100142, Peoples R China
3.Cardiff Univ, Sch Med, Metastasis & Angiogenesis Res Grp, Cardiff CF14 4XN, S Glam, Wales
Recommended Citation
GB/T 7714
Xie, Fei,Ye, Lin,Chen, Jinfeng,et al. The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2011,9.
APA Xie, Fei.,Ye, Lin.,Chen, Jinfeng.,Wu, Nan.,Zhang, Zhiqian.,...&Jiang, Wen G..(2011).The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance.JOURNAL OF TRANSLATIONAL MEDICINE,9.
MLA Xie, Fei,et al."The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance".JOURNAL OF TRANSLATIONAL MEDICINE 9(2011).
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