|The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance|
|Xie, Fei1,2,3; Ye, Lin3; Chen, Jinfeng1,2; Wu, Nan1,2; Zhang, Zhiqian1,2; Yang, Yue1,2; Zhang, Lijian1,2; Jiang, Wen G.3|
|关键词||metastasis suppressor-1 MTSS1 MIM oesophageal squamous cell carcinoma metastasis|
|刊名||JOURNAL OF TRANSLATIONAL MEDICINE|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, Research & Experimental|
|研究领域[WOS]||Research & Experimental Medicine|
|关键词[WOS]||MISSING-IN-METASTASIS ; CANCER-CELLS ; BREAST-CANCER ; MIM-B ; BLADDER-CANCER ; EXPRESSION ; ACTIN ; PROTEIN ; DOMAIN ; GENE|
Background: Metastasis suppressor-1 (MTSS1) has been proposed to function as a cytoskeletal protein with a role in cancer metastasis. Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers, yet the clinical relevance of MTSS1 in oesophageal squamous cell carcinoma (ESCC) has not been reported.
Methods: In this study, we assessed the expression levels of MTSS1 in tumours and its matched adjacent non-tumour tissues obtained from 105 ESCC patients. We also used ESCC cells with differing MTSS1 expression and assessed the influence of MTSS1 on ESCC cells.
Results: Down-regulation of MTSS1 expression was observed both in oesophageal tumour tissues and ESCC cancer cell lines. We also reported that MTSS1 expression was associated with tumour grade (p = 0.024), lymph node metastasis (p = 0.010) and overall survival (p = 0.035). Patients with high levels of MTSS1 transcripts had a favorable prognosis in comparison with those who had reduced or absent expression levels. Using over-expression and knockdown approach, we created sublines from ESCC cells and further demonstrated that MTSS1 expression in ESCC cells significantly influenced the aggressiveness of the oesophageal cancer cells, by reducing their cellular migration and in vitro invasiveness.
Conclusion: MTSS1 serves as a potential prognostic indicator in human ESCC and may be an important target for cancer therapy.
|资助机构||Cancer Research Wales ; Albert Hung Foundation ; Cardiff University|
|作者单位||1.Beijing Canc Hosp, Beijing 100142, Peoples R China|
2.Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Thorac Surg, Beijing 100142, Peoples R China
3.Cardiff Univ, Sch Med, Metastasis & Angiogenesis Res Grp, Cardiff CF14 4XN, S Glam, Wales
|Xie, Fei,Ye, Lin,Chen, Jinfeng,et al. The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2011,9.|
|APA||Xie, Fei.,Ye, Lin.,Chen, Jinfeng.,Wu, Nan.,Zhang, Zhiqian.,...&Jiang, Wen G..(2011).The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance.JOURNAL OF TRANSLATIONAL MEDICINE,9.|
|MLA||Xie, Fei,et al."The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance".JOURNAL OF TRANSLATIONAL MEDICINE 9(2011).|