学科主题公共卫生
The impact of cesarean section on offspring overweight and obesity: a systematic review and meta-analysis
Li, H-t1,2; Zhou, Y-b1,2; Liu, J-m1,2
关键词cesarean section offspring systematic review meta-analysis
刊名INTERNATIONAL JOURNAL OF OBESITY
2013-07-01
DOI10.1038/ijo.2012.195
37期:7页:893-899
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Nutrition & Dietetics
研究领域[WOS]Endocrinology & Metabolism ; Nutrition & Dietetics
关键词[WOS]GUT MICROBIOTA ; BIRTH COHORT ; INCREASED RISK ; DELIVERY ; CHILDHOOD ; CHILDREN ; ADULTHOOD ; ADOLESCENCE ; PREDICTORS ; LEPTIN
英文摘要

Studies have reported inconsistent results concerning the association of cesarean section with offspring obesity. We performed a systematic review and meta-analysis to examine whether cesarean section increases the risk of later overweight and obesity. Pubmed, Embase and Web of Science were searched using different combinations of two groups of keywords: ′cesarean′ and ′overweight/obesity′. Cohort or case-control studies that reported the association of cesarean section with childhood (3-8 years), adolescence (9-18 years) and/or adult (> 19 years) overweight/obesity were eligible. Where possible, adjusted risk estimates were pooled using a random effects model; otherwise unadjusted estimates were pooled. Statistical heterogeneity was assessed with I-2 statistics; the values of 25%, 50% and 75% were considered to indicate low, medium and high heterogeneity, respectively. We conducted a subgroup analysis to identify the sources of heterogeneity according to study quality defined on the basis of the Newcastle-Ottawa Scale. In total, two case-control and seven cohort studies were identified for the literature review and 15 separate risk estimates were included in the meta-analysis. The overall pooled odds ratio (OR) of overweight/obesity for offspring delivered by cesarean section compared with those born vaginally was 1.33 (95% confidence interval (CI) 1.19, 1.48; I-2 63%); the OR was 1.32 (1.15, 1.51) for children, 1.24 (1.00, 1.54) for adolescents and 1.50 (1.02, 2.20) for adults. In subgroup analysis, the overall pooled OR was 1.18 (1.09, 1.27; I-2 29%) for high-quality studies and 1.78 (1.43, 2.22; I-2 24%) for medium-quality (P for interaction 0.0005); no low-quality studies were identified. The ORs for children, adolescents and adults all tended to be lower for high-quality studies compared with medium-quality studies. Our results indicated that cesarean section was moderately associated with offspring overweight and obesity. This finding has public health implications, given the increase in cesarean births in many countries.

语种英语
WOS记录号WOS:000321567500001
引用统计
被引频次:72[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62443
专题北京大学公共卫生学院_北京大学生育健康研究所
作者单位1.Peking Univ Hlth Sci Ctr, Sch Publ Hlth, Key Lab Reprod Hlth, Inst Reprod & Child Hlth,Minist Hlth, Beijing 100191, Peoples R China
2.Peking Univ Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
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Li, H-t,Zhou, Y-b,Liu, J-m. The impact of cesarean section on offspring overweight and obesity: a systematic review and meta-analysis[J]. INTERNATIONAL JOURNAL OF OBESITY,2013,37(7):893-899.
APA Li, H-t,Zhou, Y-b,&Liu, J-m.(2013).The impact of cesarean section on offspring overweight and obesity: a systematic review and meta-analysis.INTERNATIONAL JOURNAL OF OBESITY,37(7),893-899.
MLA Li, H-t,et al."The impact of cesarean section on offspring overweight and obesity: a systematic review and meta-analysis".INTERNATIONAL JOURNAL OF OBESITY 37.7(2013):893-899.
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