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学科主题: 基础医学
题名:
Essential role of NR2B-containing NMDA receptor-ERK pathway in nucleus accumbens shell in morphine-associated contextual memory
作者: Xu, Ya1,2,3,4; Lv, Xiu-Fang1,2,3,4; Cui, Cai-Lian1,2,3,4; Ge, Fei-Fei1,2,3,4; Li, Yi-Jing1,2,3,4; Zhang, Hao-Lin1,2,3,4
关键词: Extracellular signal-regulated kinase 1/2 (ERK1/2) ; NR2B-containing NMDA receptor ; Morphine ; Conditioned place preference ; Nucleus accumbens (NAc)
刊名: BRAIN RESEARCH BULLETIN
发表日期: 2012-10-01
DOI: 10.1016/j.brainresbull.2012.06.012
卷: 89, 期:1-2, 页:22-30
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; COCAINE-SEEKING BEHAVIOR ; SIGNAL-REGULATED KINASE ; GLUTAMATE RECEPTORS ; DOPAMINE-RECEPTORS ; PREFRONTAL CORTEX ; VENTRAL STRIATUM ; HEROIN SEEKING ; FOS EXPRESSION ; CREB ACTIVITY
英文摘要:

Learned associations between the rewarding effect of addictive drugs and drug-paired contexts resist extinction and contribute to the high rate of relapse observed in drug addicts. Although it has been shown that extracellular signal-regulated kinase 1/2 (ERK1/2) activity in the nucleus accumbens (NAc) is modulated by the primary rewarding effect of opiates, little is known as to its role in the morphine-associated contextual memory. In the present study, we investigated the ERK1/2 activity indicated by phosphorylated ERK1/2 (pERK1/2) levels in rats using a morphine-induced conditioned place preference (CPP) procedure. Our results showed that, in rats that had undergone morphine conditioning, after testing (expression phase) pERK1/2 in the NAc shell but not the NAc core or the adjacent caudate putamen was specifically increased. pERK1/2 levels in several other parts of the brain involved in drug-seeking, such as the medial prefrontal cortex, dorsal hippocampus, and basolateral amygdala, showed no significant changes. A significant positive correlation was observed between the elevated pERK1/2 level in the NAc shell and the degree of conditioned preference for morphine-associated contexts. Bilateral injection of an inhibitor of ERK activation into the NAc shell attenuated ERK1/2 phosphorylation and prevented the expression of morphine CPP, but injections into the core did not. Selective inhibition of NR2B-containing NMDA receptor in the NAc shell by ifenprodil prevented CPP expression and down-regulated local ERK1/2 phosphorylation. These findings collectively suggest that recall of morphine-associated contextual memory depends specifically upon ERK1/2 activation in the NAc shell and that ERK1/2 phosphorylation is regulated by the upstream NR2B-containing NMDA receptor. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2009CB522003 ; 30970933
项目资助者: National Basic Research Program ; National Natural Science Foundation of China
WOS记录号: WOS:000308524100004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62444
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
4.Minist Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Ya,Lv, Xiu-Fang,Cui, Cai-Lian,et al. Essential role of NR2B-containing NMDA receptor-ERK pathway in nucleus accumbens shell in morphine-associated contextual memory[J]. BRAIN RESEARCH BULLETIN,2012,89(1-2):22-30.
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