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学科主题: 临床医学
题名:
5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma
作者: Wang, Wenming1; Wang, Jing1; Li, Min2; Ying, Jianming3; Jing, Hongmei1
关键词: PTPL1 ; mehthylation ; lymphoma ; diffuse large B-cell lymphoma ; 5-azacytidine
刊名: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
发表日期: 2015-09-01
DOI: 10.3892/ijmm.2015.2269
卷: 36, 期:3, 页:698-704
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: FAS-MEDIATED APOPTOSIS ; T-CELL LEUKEMIA ; DNA METHYLATION ; MYELODYSPLASTIC SYNDROMES ; HEPATOCELLULAR-CARCINOMA ; MYELOID-LEUKEMIA ; CANCER ; EXPRESSION ; GENES ; PHOSPHATASE
英文摘要:

Non-Hodgkin lymphoma (NHL) consists of various lymphoid malignancies with a diverse clinical pathology and biological characteristics. Methylation of cytosine residues by DNA methyltransferases at CpG dinucleotides in the promoter region of the genes is a major epigenetic modification in mammalian genomes that can have profound effects on gene expression. The PTPL1 methylation pattern was screened by methylation-specific polymerase chain reaction (MSP) in 7 lymphoma-derived cell lines and in 47 samples of diffuse large B cell lymphoma (DLBCL). The PTPL1 gene was hypermethylated in the CA46, Raji, Jurkat and DB cell lines; however, it was unmethylated in the Hut78, Maver and Z138 cell lines. The expression of PTPL1 mRNA was re-inducible by 5-azacytidine (5-Aza), an agent of DNA demethylation. The methylations were detected in 59.6% of DLBCL versus 6.3% in reactive lymph node proliferation. Therefore, the present data showed that PTPL1 was epigenetically regulated in NHL suggesting an involvement of the PTPL1 tumor-suppressor genes in NHL, and highlights 5-Aza as a potential therapeutic candidate for NHL.

语种: 英语
WOS记录号: WOS:000361134700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62449
Appears in Collections:北京大学第三临床医学院_血液内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Hematol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Pathol, Beijing 100191, Peoples R China
3.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Pathol, Beijing 100021, Peoples R China

Recommended Citation:
Wang, Wenming,Wang, Jing,Li, Min,et al. 5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2015,36(3):698-704.
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