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5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma
Wang, Wenming1; Wang, Jing1; Li, Min2; Ying, Jianming3; Jing, Hongmei1
关键词PTPL1 mehthylation lymphoma diffuse large B-cell lymphoma 5-azacytidine
刊名INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
2015-09-01
DOI10.3892/ijmm.2015.2269
36期:3页:698-704
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]FAS-MEDIATED APOPTOSIS ; T-CELL LEUKEMIA ; DNA METHYLATION ; MYELODYSPLASTIC SYNDROMES ; HEPATOCELLULAR-CARCINOMA ; MYELOID-LEUKEMIA ; CANCER ; EXPRESSION ; GENES ; PHOSPHATASE
英文摘要

Non-Hodgkin lymphoma (NHL) consists of various lymphoid malignancies with a diverse clinical pathology and biological characteristics. Methylation of cytosine residues by DNA methyltransferases at CpG dinucleotides in the promoter region of the genes is a major epigenetic modification in mammalian genomes that can have profound effects on gene expression. The PTPL1 methylation pattern was screened by methylation-specific polymerase chain reaction (MSP) in 7 lymphoma-derived cell lines and in 47 samples of diffuse large B cell lymphoma (DLBCL). The PTPL1 gene was hypermethylated in the CA46, Raji, Jurkat and DB cell lines; however, it was unmethylated in the Hut78, Maver and Z138 cell lines. The expression of PTPL1 mRNA was re-inducible by 5-azacytidine (5-Aza), an agent of DNA demethylation. The methylations were detected in 59.6% of DLBCL versus 6.3% in reactive lymph node proliferation. Therefore, the present data showed that PTPL1 was epigenetically regulated in NHL suggesting an involvement of the PTPL1 tumor-suppressor genes in NHL, and highlights 5-Aza as a potential therapeutic candidate for NHL.

语种英语
WOS记录号WOS:000361134700010
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62449
专题北京大学第三临床医学院_血液内科
作者单位1.Peking Univ, Hosp 3, Dept Hematol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Pathol, Beijing 100191, Peoples R China
3.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Pathol, Beijing 100021, Peoples R China
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Wang, Wenming,Wang, Jing,Li, Min,et al. 5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2015,36(3):698-704.
APA Wang, Wenming,Wang, Jing,Li, Min,Ying, Jianming,&Jing, Hongmei.(2015).5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,36(3),698-704.
MLA Wang, Wenming,et al."5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 36.3(2015):698-704.
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