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学科主题: 公共卫生
题名:
The Cardiopulmonary Effects of Ambient Air Pollution and Mechanistic Pathways: A Comparative Hierarchical Pathway Analysis
作者: Roy, Ananya1; Gong, Jicheng2,3; Thomas, Duncan C.4; Zhang, Junfeng2,3; Kipen, Howard M.5; Rich, David Q.6; Zhu, Tong7,8; Huang, Wei9,10; Hu, Min7,8; Wang, Guangfa11; Wang, Yuedan12; Zhu, Ping13; Lu, Shou-En14; Ohman-Strickland, Pamela14; Diehl, Scott R.15; Eckel, Sandrah P.4
刊名: PLOS ONE
发表日期: 2014-12-12
DOI: 10.1371/journal.pone.0114913
卷: 9, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HEART-RATE-VARIABILITY ; HEALTHY-YOUNG ADULTS ; OXIDATIVE STRESS ; BEIJING OLYMPICS ; DIESEL EXHAUST ; CARDIOVASCULAR-DISEASE ; BLOOD-COAGULATION ; ELDERLY SUBJECTS ; TIME-COURSE ; EXPOSURE
英文摘要:

Previous studies have investigated the associations between exposure to ambient air pollution and biomarkers of physiological pathways, yet little has been done on the comparison across biomarkers of different pathways to establish the temporal pattern of biological response. In the current study, we aim to compare the relative temporal patterns in responses of candidate pathways to different pollutants. Four biomarkers of pulmonary inflammation and oxidative stress, five biomarkers of systemic inflammation and oxidative stress, ten parameters of autonomic function, and three biomarkers of hemostasis were repeatedly measured in 125 young adults, along with daily concentrations of ambient CO, PM2.5, NO2, SO2, EC, OC, and sulfate, before, during, and after the Beijing Olympics. We used a two-stage modeling approach, including Stage I models to estimate the association between each biomarker and pollutant over each of 7 lags, and Stage II mixed-effect models to describe temporal patterns in the associations when grouping the biomarkers into the four physiological pathways. Our results show that candidate pathway groupings of biomarkers explained a significant amount of variation in the associations for each pollutant, and the temporal patterns of the biomarker pollutant-lag associations varied across candidate pathways (p<0.0001) and were not linear (from lag 0 to lag 3: p=0.0629, from lag 3 to lag 6: p=0.0005). These findings suggest that, among this healthy young adult population, the pulmonary inflammation and oxidative stress pathway is the first to respond to ambient air pollution exposure (within 24 hours) and the hemostasis pathway responds gradually over a 2-3 day period. The initial pulmonary response may contribute to the more gradual systemic changes that likely ultimately involve the cardiovascular system.

语种: 英语
所属项目编号: 1R01ES015864 ; P30ES005022 ; 5P30ES007048 ; 4760-RPFA05-3 ; OITC-G08026056 ; HB200504-6 ; HB200504-2
项目资助者: National Institute of Environmental Health Sciences ; Health Effects Institute ; Beijing Environment Protection Bureau ; Beijing Council of Science and Technology
WOS记录号: WOS:000346375400063
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62455
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Duke Univ, Nicholas Sch Environm, Durham, NC USA
2.Duke Univ, Duke Global Hlth Inst, Durham, NC USA
3.Peking Univ, Inst Environm Med, Beijing 100871, Peoples R China
4.Yale Univ, Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT USA
5.Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
6.Rutgers State Univ, Rutgers Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Piscataway, NJ USA
7.Univ Rochester, Sch Med & Dent, Dept Publ Hlth Sci, Rochester, NY USA
8.Peking Univ, Coll Environm Sci & Engn, State Key Lab Environm Simulat & Pollut Control, Beijing 100871, Peoples R China
9.Peking Univ, Ctr Environm & Hlth, Beijing 100871, Peoples R China
10.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100871, Peoples R China
11.Peking Univ, Hosp 1, Dept Pulm Med, Beijing 100871, Peoples R China
12.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100871, Peoples R China
13.Peking Univ, Hosp 1, Dept Hematol, Beijing 100871, Peoples R China
14.Rutgers State Univ, Sch Publ Hlth, Dept Biostat, Piscataway, NJ USA
15.Rutgers State Univ, Sch Dent, Ctr Pharmacogen & Complex Dis, Newark, NJ USA

Recommended Citation:
Roy, Ananya,Gong, Jicheng,Thomas, Duncan C.,et al. The Cardiopulmonary Effects of Ambient Air Pollution and Mechanistic Pathways: A Comparative Hierarchical Pathway Analysis[J]. PLOS ONE,2014,9(12).
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