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学科主题基础医学
Association of 14-3-37 and phosphorylated bad attenuates injury in ischemic astrocytes
Chen, XQ; Fung, YWW; Yu, ACH
关键词astrocytes apoptosis ischemia p-Bad signal transduction 14-3-3 gamma
刊名JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
2005-03-01
DOI10.1038/sj.jcbfm.9600032
25期:3页:338-347
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Hematology ; Neurosciences
研究领域[WOS]Endocrinology & Metabolism ; Hematology ; Neurosciences & Neurology
关键词[WOS]CEREBROSPINAL-FLUID ; PRIMARY CULTURES ; CELL-DIVISION ; BCL-X ; PROTEINS ; APOPTOSIS ; EXPRESSION ; ACTIVATION ; SURVIVAL ; DEATH
英文摘要

Our recent findings indicate an induced upregulation of 14-3-3 gamma mRNA and protein in ischemic cortical astrocytes. Despite being brain-specific, the functional role of 14-3-3 gamma in the brain still remains largely unknown. In this study, we show that among all the 14-3-3 isoforms, only the gamma isoform is inducible under ischemia in astrocytes. Furthermore, this upregulation of 14-3-3 gamma may play a specific protective role in astrocytes under ischemia. Overexpression experiments and antisense treatment show that an elevation of 14-3-3 gamma protein in astrocytes promotes survival, while a decrease in 14-3-3 gamma enhances apoptosis in astrocytes under ischemia. Under ischemia, endogenous 14-3-3 gamma binds p-Bad, thus preventing Bad from entering mitochondria to initiate apoptosis. Therefore, 14-3-3 gamma is selectively induced during ischemia to protect astrocytes from apoptosis through p-Bad-related signaling.

语种英语
WOS记录号WOS:000227307800007
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被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62456
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Key Lab Neurosci, Minist Educ PKU, Beijing, Peoples R China
3.Hong Kong DNA Chips Ltd, Hong Kong, Hong Kong, Peoples R China
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Chen, XQ,Fung, YWW,Yu, ACH. Association of 14-3-37 and phosphorylated bad attenuates injury in ischemic astrocytes[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,2005,25(3):338-347.
APA Chen, XQ,Fung, YWW,&Yu, ACH.(2005).Association of 14-3-37 and phosphorylated bad attenuates injury in ischemic astrocytes.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,25(3),338-347.
MLA Chen, XQ,et al."Association of 14-3-37 and phosphorylated bad attenuates injury in ischemic astrocytes".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 25.3(2005):338-347.
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