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学科主题: 基础医学
题名:
Effects of Echinacoside on Histio-central Levels of Active Mass in Middle Cerebral Artery Occlusion Rats
作者: We Li Li1,2; Chen Hong1,2; Jiang Yong3; Tu Peng Fei3; Zhong Ming1,2; Du Juan1,2; Liu Fei1,2; Wang Lei1,2; Liu Chun Yang1,2
关键词: Echinacoside ; Norepinephrine (NE) dopamine (DA) homovanillic acid (HVA) 3,4-dihydroxyphenylethanoid acid (DOPAC) 5-hydroxyindoleacetic acid (HIAA) 5-hydroxytryptamine (5-HT) ; Middle cerebral artery occlusion(MCAO) ; Brain microdialysis ; rats
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2012-04-01
DOI: 10.3967/0895-3988.2012.02.017
卷: 25, 期:2, 页:238-244
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: 1-METHYL-4-PHENYLPYRIDINIUM ION ; PHENYLETHANOID GLYCOSIDES ; INDUCED APOPTOSIS ; CISTANCHES-SALSA ; NEURONAL CELLS ; RESCUES ; ACTEOSIDE ; BRAIN
英文摘要:

Objective To investigate the effects of echinacoside on the extracellular striatal levels of norepinephrine (NE), dopamine (DA), homovanillic acid (HVA), 3, 4-dihydroxyphenylethanoid acid (DOPAC), 5-hydroxyindoleacetic acid (HIAA), and 5-hydroxytryptamine(5-HT) in middle cerebral artery occlusion (MCAO rats.

Methods The middle cerebral artery was occluded in male Sprague-Dawley rats. Three days later microdialysis probes were placed into the right striatum of MCAO rat brains and the brains were perfused with Ringer′s solution at a rate of 1.5 mu L/min. Cerebral microdialysates were collected every 30 minutes from awake and freely moving rats before assaying for NE, DA, HVA, DOPAC, HIAA, and 5-HT levels by reverse phase HPLC with electrochemistry.

Results Three days after MCAO, the extracellular striatal levels of NE, DA, DOPAC, HIAA, HVA, and 5-HT of the MCAO rats increased significantly (at least P<0.05 vs. control). However, simultaneous treatment with echinacoside (30.0 or 15.0 mg/kg) attenuated these increases (at least P<0.05 vs. non-treated model rats).

Conclusion These results imply that echinacoside may protect striatal dopa minergic neurons from the injury induced by MCAO and may help prevent and treat cerebral ischemic diseases.

语种: 英语
所属项目编号: 30560171 ; 30860334
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000304496200017
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62458
Appears in Collections:基础医学院_中西医结合学系_期刊论文

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作者单位: 1.Shihezi Univ, Minist Educ, Key Lab Xinjiang Phytomed Resources, Shihezi 832002, Xinjiang, Peoples R China
2.Shihezi Univ, Coll Pharm, Dept Pharmacol, Shihezi 832002, Xinjiang, Peoples R China
3.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China

Recommended Citation:
We Li Li,Chen Hong,Jiang Yong,et al. Effects of Echinacoside on Histio-central Levels of Active Mass in Middle Cerebral Artery Occlusion Rats[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2012,25(2):238-244.
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