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学科主题: 临床医学
题名:
Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: Association with tumor progression
作者: Koensgen, Dominique; Mustea, Alexander; Klaman, Irina; Sun, Pengming; Zafrakas, Menelaos; Lichtenegger, Wemer; Denkert, Carsten; Dahl, Edgar; Sehouli, Jalid
关键词: ovarian cancer ; PAI-1 ; PAI-RBP1 ; SERBP1
刊名: GYNECOLOGIC ONCOLOGY
发表日期: 2007-11-01
DOI: 10.1016/j.ygyno.2007.06.023
卷: 107, 期:2, 页:266-273
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: PLATINUM-BASED CHEMOTHERAPY ; PLASMINOGEN-ACTIVATOR UPA ; INHIBITOR PAI-1 ; BREAST-CANCER ; UROKINASE UPA ; MESSENGER-RNA ; TYPE-1 ; RECEPTOR ; SURVIVAL ; BENIGN
英文摘要:

Objective. The plasminogen activator system (PA) plays an important role in invasion and metastasis of solid tumors. The PA Inhibitor type I (PAI-1) is the main physiologic regulator of plasminogen activation. A recently characterized protein, PAI-RBP1 (PAI-1 mRNA Binding Protein 1), appears to regulate the stability of PAI-1 mRNA. Expression of PAI-RBP1 (the new, approved gene symbol is SERBP1) has not been previously analyzed in human tumors. We present herein for the first time expression analysis of PAI-RBP1 in epithelial ovarian cancer.

Methods. PAI-RBP1 was identified as gene overexpressed in ovarian cancer by an in silico approach using EST database mining. A thorough expression analysis of PAI-RBP1 and PAI-1 was performed in normal ovary (n=4), benign (n=6) and malignant (n=42) ovarian lesions using non-radioactive RNA in situ hybridization and immunohistochemistry, respectively.

Results. PAI-RBP1 mRNA and PAI-1 were significantly overexpressed in tumor epithelial cells as compared to benign and normal ovarian tissue. A significant correlation between PAI-RBP1 expression and advanced disease stage (FIGO) was found (p=0.042).

Conclusion. In ovarian cancer, PAI-RBP1 is significantly overexpressed in tumor epithelial cells, suggesting a biological role in tumor invasion and metastasis. Its expression is higher in advanced disease, thus the prognostic significance of PAI-PBP1 in ovarian cancer remains to be evaluated in further studies. (c) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000250654900021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62460
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Emil Von Behring Hosp, Inst Pathol, Berlin, Germany
2.Univ Hosp RWTH Aachen, Inst Pathol, D-5100 Aachen, Germany
3.Charite Univ Med Berlin, Inst Pathol, Berlin, Germany
4.Charite Univ Med Berlin, Dept Obstet & Gynecol, Berlin, Germany
5.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China

Recommended Citation:
Koensgen, Dominique,Mustea, Alexander,Klaman, Irina,et al. Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: Association with tumor progression[J]. GYNECOLOGIC ONCOLOGY,2007,107(2):266-273.
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