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Ultrafine carbon black attenuates the antihypertensive effect of captopril in spontaneously hypertensive rats
Zhang, Xinru; Chen, Yiyong; Wei, Hongying; Qin, Yu; Hao, Yu; Zhu, Yidan; Deng, Furong; Guo, Xinbiao
关键词Angiotensin II antihypertensive blood pressure captopril spontaneously hypertensive rats ultrafine carbon black
刊名INHALATION TOXICOLOGY
2014-12-01
DOI10.3109/08958378.2014.965558
26期:14页:853-860
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
资助者National Natural Science Foundation of China ; National Key Technologies R&amp ; D Program of China ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; National Key Technologies R&amp ; D Program of China ; National High Technology Research and Development Program of China
研究领域[WOS]Toxicology
关键词[WOS]PARTICULATE AIR-POLLUTION ; BLOOD-PRESSURE ; HEART-RATE ; PARTICLES ; EXPOSURE ; MATTER ; LUNG ; FINE ; TRANSLOCATION ; CONSTITUENTS
英文摘要

Particulate matter (PM) has been associated with increased blood pressure (BP) by affecting renin-angiotensin system (RAS) on a systemic level in spontaneously hypertensive rats (SHR). RAS in SHR is also an important target for the angiotensin converting enzyme (ACE) inhibitors such as captopril. We aimed to determine if ultrafine carbon black (UCB) could affect antihypertensive effect of captopril in SHR. The rats were randomly divided into six groups. Group 1 did not receive intratracheal instillation; group 2 received saline instillation plus captopril administration; groups 3, 4 and 5 received 0.15 mg/kg, 0.45 mg/kg and 1.35 mg/kg UCB per instillation plus captopril administration, respectively; group 6 received 1.35 mg/kg UCB instillation only. Rats in the above groups were intratracheally instilled with saline or UCB once every two days for three times and captopril was administered to group 2-5 after the final UCB treatment, once a day for one week. The BP was measured 24 h after each intratracheal instillation. During captopril administration and 24 h after last captopril administration, we measured BP every two days for four times. Our results showed that UCB at the dose of 1.35 mg/kg induced pulmonary and systemic inflammation in SHR. Captopril reduced BP in rats exposed to 0, 0.15 and 0.45 mg/kg UCB seven and eleven days after the first UCB instillation, and had no effect on BP in rats exposed to 1.35 mg/kg UCB. Captopril also reduced angiotensin II (AngII) in rats exposed to saline. The reduction, however, was attenuated with increasing doses of UCB. We conclude that UCB attenuated the antihypertensive effect of captopril in SHR, and the effect was accompanied by a systemic increase in the concentration of AngII.

语种英语
所属项目编号21077006 ; 30571534 ; 2006BAI19B06 ; 2012AA062804
资助者National Natural Science Foundation of China ; National Key Technologies R&amp ; D Program of China ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; National Key Technologies R&amp ; D Program of China ; National High Technology Research and Development Program of China
WOS记录号WOS:000345980700003
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62468
Collection北京大学公共卫生学院
作者单位Peking Univ, Dept Occupat & Environm Hlth Sci, Sch Publ Hlth, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xinru,Chen, Yiyong,Wei, Hongying,et al. Ultrafine carbon black attenuates the antihypertensive effect of captopril in spontaneously hypertensive rats[J]. INHALATION TOXICOLOGY,2014,26(14):853-860.
APA Zhang, Xinru.,Chen, Yiyong.,Wei, Hongying.,Qin, Yu.,Hao, Yu.,...&Guo, Xinbiao.(2014).Ultrafine carbon black attenuates the antihypertensive effect of captopril in spontaneously hypertensive rats.INHALATION TOXICOLOGY,26(14),853-860.
MLA Zhang, Xinru,et al."Ultrafine carbon black attenuates the antihypertensive effect of captopril in spontaneously hypertensive rats".INHALATION TOXICOLOGY 26.14(2014):853-860.
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