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学科主题: 药学
题名:
Targeting Therapy with Mitosomal Daunorubicin plus Amlodipine Has the Potential To Circumvent Intrinsic Resistant Breast Cancer
作者: Zhang, Yan; Li, Ruo-Jing; Ying, Xue; Tian, Wei; Yao, Hong-Juan; Men, Ying; Yu, Yang; Zhang, Liang; Ju, Rui-Jun; Wang, Xiao-Xing; Zhou, Jia; Chen, Jing-Xian; Li, Nan; Lu, Wan-Liang1
关键词: Intrinsic drug resistance ; mitochondrial targeting ; apoptosis ; breast cancer ; mitosomal daunorubicin plus amlodipine
刊名: MOLECULAR PHARMACEUTICS
发表日期: 2011
DOI: 10.1021/mp100249x
卷: 8, 期:1, 页:162-175
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: BCL-2 FAMILY PROTEINS ; MITOCHONDRIAL GENE-THERAPY ; HUMAN LEUKEMIA-CELLS ; CYTOCHROME-C ; PERMEABILITY TRANSITION ; ANTICANCER AGENT ; STEM-CELLS ; IN-VITRO ; APOPTOSIS ; LIPOSOMES
英文摘要:

Intrinsic resistance of cancers is a major cause of failure in chemotherapy. We proposed here a strategy to overcome intrinsic resistance by constructing cancer cell mitochondria-specifically targeting drug-loaded liposomes, namely, mitosomal daunorubicin plus amlodipine. Anticancer agent daunorubicin and apoptotic inducer amlodipine were loaded together into the mitosomes, and targeting molecule dequalinium was modified on the surface. Evaluations were performed on the breast cancer MCF-7 and resistant MCF-7/adr cells and in;animals. Mitosomal daunorubicin plus amlodipine were about 97 nm, selectively accumulated in mitochondria, induced the swelling and disruption of mitochondria, dissipated the mitochondrial membrane potential, released a large amount of cytochrome C by translocation, cleaved Bid, and initiated a cascade of caspase 8 and 3 reactions. A robust anticancer effect was evidenced in vivo. Mitochondria-specifically targeting drug-loaded liposomes would provide a new strategy tor treating resistant cancers.

语种: 英语
所属项目编号: 7091005 ; 30772664 ; 2009CB930300
项目资助者: Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Key Science Research Program of China (973 program)
WOS记录号: WOS:000286915000017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62475
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Yan,Li, Ruo-Jing,Ying, Xue,et al. Targeting Therapy with Mitosomal Daunorubicin plus Amlodipine Has the Potential To Circumvent Intrinsic Resistant Breast Cancer[J]. MOLECULAR PHARMACEUTICS,2011,8(1):162-175.
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