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Targeting Therapy with Mitosomal Daunorubicin plus Amlodipine Has the Potential To Circumvent Intrinsic Resistant Breast Cancer
Zhang, Yan; Li, Ruo-Jing; Ying, Xue; Tian, Wei; Yao, Hong-Juan; Men, Ying; Yu, Yang; Zhang, Liang; Ju, Rui-Jun; Wang, Xiao-Xing; Zhou, Jia; Chen, Jing-Xian; Li, Nan; Lu, Wan-Liang1
关键词Intrinsic drug resistance mitochondrial targeting apoptosis breast cancer mitosomal daunorubicin plus amlodipine
刊名MOLECULAR PHARMACEUTICS
2011
DOI10.1021/mp100249x
8期:1页:162-175
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]BCL-2 FAMILY PROTEINS ; MITOCHONDRIAL GENE-THERAPY ; HUMAN LEUKEMIA-CELLS ; CYTOCHROME-C ; PERMEABILITY TRANSITION ; ANTICANCER AGENT ; STEM-CELLS ; IN-VITRO ; APOPTOSIS ; LIPOSOMES
英文摘要

Intrinsic resistance of cancers is a major cause of failure in chemotherapy. We proposed here a strategy to overcome intrinsic resistance by constructing cancer cell mitochondria-specifically targeting drug-loaded liposomes, namely, mitosomal daunorubicin plus amlodipine. Anticancer agent daunorubicin and apoptotic inducer amlodipine were loaded together into the mitosomes, and targeting molecule dequalinium was modified on the surface. Evaluations were performed on the breast cancer MCF-7 and resistant MCF-7/adr cells and in;animals. Mitosomal daunorubicin plus amlodipine were about 97 nm, selectively accumulated in mitochondria, induced the swelling and disruption of mitochondria, dissipated the mitochondrial membrane potential, released a large amount of cytochrome C by translocation, cleaved Bid, and initiated a cascade of caspase 8 and 3 reactions. A robust anticancer effect was evidenced in vivo. Mitochondria-specifically targeting drug-loaded liposomes would provide a new strategy tor treating resistant cancers.

语种英语
WOS记录号WOS:000286915000017
项目编号7091005 ; 30772664 ; 2009CB930300
资助机构Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Key Science Research Program of China (973 program)
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62475
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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Zhang, Yan,Li, Ruo-Jing,Ying, Xue,et al. Targeting Therapy with Mitosomal Daunorubicin plus Amlodipine Has the Potential To Circumvent Intrinsic Resistant Breast Cancer[J]. MOLECULAR PHARMACEUTICS,2011,8(1):162-175.
APA Zhang, Yan.,Li, Ruo-Jing.,Ying, Xue.,Tian, Wei.,Yao, Hong-Juan.,...&Lu, Wan-Liang.(2011).Targeting Therapy with Mitosomal Daunorubicin plus Amlodipine Has the Potential To Circumvent Intrinsic Resistant Breast Cancer.MOLECULAR PHARMACEUTICS,8(1),162-175.
MLA Zhang, Yan,et al."Targeting Therapy with Mitosomal Daunorubicin plus Amlodipine Has the Potential To Circumvent Intrinsic Resistant Breast Cancer".MOLECULAR PHARMACEUTICS 8.1(2011):162-175.
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