北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis
作者: Peng, Peng; Xiong, De-Cai; Ye, Xin-Shan
关键词: o-Methylphenylthioglycoside ; Preactivation ; Oligosaccharide ; Aglycon transfer ; Glycosylation
刊名: CARBOHYDRATE RESEARCH
发表日期: 2014-01-30
DOI: 10.1016/j.carres.2013.11.009
卷: 384, 页:1-8
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: INTERMOLECULAR AGLYCON TRANSFER ; CHEMOSELECTIVE GLYCOSYLATIONS ; THIOGLYCOSIDES ; DERIVATIVES ; STRATEGY ; PENTASACCHARIDE ; ACCEPTORS ; ANALOGS
英文摘要:

Thioglycosides are widely used in orthogonal glycosylation, armed-disarmed chemoselective glycosylation, and preactivation-based glycosylation. Nevertheless, aglycon transfer occasionally occurred in the glycosylation process of thioglycosides. This problem was also encountered in preactivation-based reactions, which limited the applications of preactivation-based glycosylation to some extent. To tackle this problem, sterically hindered aglycon ortho-methylphenylthioglycosides were introduced as glycosyl building blocks. These thioglycosides prevented the aglycon transfer and enhanced the efficiency of glycosyl coupling reactions, especially in the reactions of disarmed donors with armed acceptors. Moreover, these thioglycosides were employed in preactivation-based one-pot oligosaccharide assembly. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2012AA021504 ; 2012ZX09502001-001 ; 2012CB822100 ; 21232002
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Higher Education Young Elite Teacher Project
WOS记录号: WOS:000329439300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62479
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Peng, Peng,Xiong, De-Cai,Ye, Xin-Shan. ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis[J]. CARBOHYDRATE RESEARCH,2014,384:1-8.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Peng, Peng]'s Articles
[Xiong, De-Cai]'s Articles
[Ye, Xin-Shan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Peng, Peng]‘s Articles
[Xiong, De-Cai]‘s Articles
[Ye, Xin-Shan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace