IR@PKUHSC  > 北京大学药学院
学科主题药学
ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis
Peng, Peng; Xiong, De-Cai; Ye, Xin-Shan
关键词o-Methylphenylthioglycoside Preactivation Oligosaccharide Aglycon transfer Glycosylation
刊名CARBOHYDRATE RESEARCH
2014-01-30
DOI10.1016/j.carres.2013.11.009
384页:1-8
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
资助者Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Higher Education Young Elite Teacher Project ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Higher Education Young Elite Teacher Project
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]INTERMOLECULAR AGLYCON TRANSFER ; CHEMOSELECTIVE GLYCOSYLATIONS ; THIOGLYCOSIDES ; DERIVATIVES ; STRATEGY ; PENTASACCHARIDE ; ACCEPTORS ; ANALOGS
英文摘要

Thioglycosides are widely used in orthogonal glycosylation, armed-disarmed chemoselective glycosylation, and preactivation-based glycosylation. Nevertheless, aglycon transfer occasionally occurred in the glycosylation process of thioglycosides. This problem was also encountered in preactivation-based reactions, which limited the applications of preactivation-based glycosylation to some extent. To tackle this problem, sterically hindered aglycon ortho-methylphenylthioglycosides were introduced as glycosyl building blocks. These thioglycosides prevented the aglycon transfer and enhanced the efficiency of glycosyl coupling reactions, especially in the reactions of disarmed donors with armed acceptors. Moreover, these thioglycosides were employed in preactivation-based one-pot oligosaccharide assembly. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号2012AA021504 ; 2012ZX09502001-001 ; 2012CB822100 ; 21232002
资助者Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Higher Education Young Elite Teacher Project ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Higher Education Young Elite Teacher Project
WOS记录号WOS:000329439300001
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62479
Collection北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Peng, Peng,Xiong, De-Cai,Ye, Xin-Shan. ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis[J]. CARBOHYDRATE RESEARCH,2014,384:1-8.
APA Peng, Peng,Xiong, De-Cai,&Ye, Xin-Shan.(2014).ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis.CARBOHYDRATE RESEARCH,384,1-8.
MLA Peng, Peng,et al."ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis".CARBOHYDRATE RESEARCH 384(2014):1-8.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Peng, Peng]'s Articles
[Xiong, De-Cai]'s Articles
[Ye, Xin-Shan]'s Articles
百度学术
百度学术Similar articles in
[Peng, Peng]'s Articles
[Xiong, De-Cai]'s Articles
[Ye, Xin-Shan]'s Articles
必应学术
必应学术Similar articles in
[Peng, Peng]'s Articles
[Xiong, De-Cai]'s Articles
[Ye, Xin-Shan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.