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学科主题: 药学
题名:
Investigation of Two Flacourtiaceae Plants: Bennettiodendron leprosipes and Flacourtia ramontchi
作者: Chai, Xing-Yun1; Ren, Hong-Yan1; Xu, Zheng-Ren1; Bai, Chang-Cai1; Zhou, Fei-Ran1; Ling, Si-Kai2; Pu, Xiao-Ping2; Li, Fei-Fei1; Tu, Peng-Fei1
关键词: Bennettiodendron leprosipes ; Flacourtia ramontchi ; benosides A and B ; bennettin, flacosides A-C ; phosphodiesterase I ; Flacourtiaceae
刊名: PLANTA MEDICA
发表日期: 2009-09-01
DOI: 10.1055/s-0029-1185542
卷: 75, 期:11, 页:1246-1252
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: WATER-SOLUBLE CONSTITUENTS ; PHENOLIC GLYCOSIDES ; MEGASTIGMANE GLYCOSIDES ; DERIVATIVES ; ALCOHOL ; GLUCOSIDES ; INHIBITORS ; LIGNANS ; STEMS
英文摘要:

Investigations of two Flacourtiaceae plants, Bennettiodendron leprosipes and Flacourtia ramontchi, resulted in the isolation and structural elucidation of six new constituents including two phenolic glycosides (1 and 2), one lignan (3), two lignan glycosides (4 and 5), and a monoterpene glycoside (6), together with 22 known compounds (7-28). The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The selected isolates 1, 2, 8-10, 22-26, and some phenolic glycosides 29-42 previously isolated from another Flacourtiaceae plant, Itoa orientalis, were tested against snake venom phosphodiesterase I (PIDE I) activity. The result indicated that 22, 30, 32, 34, and 40 exhibited moderate inhibitory activities against PDE I with the values ranging from 13.15 to 20.86%, and 1, 8,10, 25, 31, 33, 35, 38, 39, and 41 showed weak inhibitory activity.

语种: 英语
所属项目编号: 985-2-063-112
项目资助者: Innovative Team in University
WOS记录号: WOS:000270401600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62480
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Pharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Chai, Xing-Yun,Ren, Hong-Yan,Xu, Zheng-Ren,et al. Investigation of Two Flacourtiaceae Plants: Bennettiodendron leprosipes and Flacourtia ramontchi[J]. PLANTA MEDICA,2009,75(11):1246-1252.
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