|N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis|
|Jin, Ke-Min1; Lu, Min2; Liu, Fang-Fang3; Gu, Jin4; Du, Xiao-Juan5,6; Xing, Bao-Cai1|
|WOS标题词||Science & Technology|
|关键词[WOS]||HEPATOCYTE GROWTH-FACTOR ; ALDRICH-SYNDROME PROTEIN ; SQUAMOUS-CELL CARCINOMA ; FOCAL ADHESION KINASE ; POSTOPERATIVE RECURRENCE ; CURATIVE RESECTION ; CANCER STATISTICS ; ALPHA-FETOPROTEIN ; ACTIN-FILAMENTS ; INVASION|
Background. Neural Wiskott-Aldrich syndrome protein (N-WASP) mediates migration and invasion in cancer cells, but its expression and clinicopathologic and prognostic importance in hepatocellular carcinoma (HCC) remain unknown. The present study was designed to address these issues.
Methods. N-WASP expression was first analyzed by Western blotting in 19 paired HCC and paratumoral liver (PTL) tissues. We further evaluated N-WASP expression immunohistochemically in samples from 119 patients with HCC. The clinicopathologic and prognostic importance of N-WASP expression were also investigated.
Results. Western blotting showed that N-WASP expression was up-regulated in 15 of 19.FICC tissues (79%), compared with PTL ones. The N-WASP-positive rate in immunohistochemical staining also was greater in HCC (63/119, 53%) than that in PTL tissues (8/119, 6%). The up-regulated N-WASP expression in HCC tissues was correlated with absence of capsule formation and predicted less overall and disease-free survival. Multivariate analysis demonstrated that N-WASP was an independent prognostic factor for overall survival and was marginally important for disease-free survival.
Conclusion. These data establish that N-WASP is highly expressed in HCC and its strong prognostic importance. Therefore, the gene/protein might serve as a potential therapeutic target for HCC. (Surgery 2013;153:518-25.)
|作者单位||1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Hepat Biliary & Pancreat Surg Un, Beijing 100142, Peoples R China|
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Genet, Beijing 100142, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Dept Colorectal Surg Unit, Beijing 100142, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100191, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Canc Res Ctr, Beijing 100191, Peoples R China
|Jin, Ke-Min,Lu, Min,Liu, Fang-Fang,et al. N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis[J]. SURGERY,2013,153(4):518-525.|
|APA||Jin, Ke-Min,Lu, Min,Liu, Fang-Fang,Gu, Jin,Du, Xiao-Juan,&Xing, Bao-Cai.(2013).N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis.SURGERY,153(4),518-525.|
|MLA||Jin, Ke-Min,et al."N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis".SURGERY 153.4(2013):518-525.|
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