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学科主题: 基础医学
题名:
N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis
作者: Jin, Ke-Min1; Lu, Min2; Liu, Fang-Fang3; Gu, Jin4; Du, Xiao-Juan5,6; Xing, Bao-Cai1
刊名: SURGERY
发表日期: 2013-04-01
DOI: 10.1016/j.surg.2012.08.067
卷: 153, 期:4, 页:518-525
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: HEPATOCYTE GROWTH-FACTOR ; ALDRICH-SYNDROME PROTEIN ; SQUAMOUS-CELL CARCINOMA ; FOCAL ADHESION KINASE ; POSTOPERATIVE RECURRENCE ; CURATIVE RESECTION ; CANCER STATISTICS ; ALPHA-FETOPROTEIN ; ACTIN-FILAMENTS ; INVASION
英文摘要:

Background. Neural Wiskott-Aldrich syndrome protein (N-WASP) mediates migration and invasion in cancer cells, but its expression and clinicopathologic and prognostic importance in hepatocellular carcinoma (HCC) remain unknown. The present study was designed to address these issues.

Methods. N-WASP expression was first analyzed by Western blotting in 19 paired HCC and paratumoral liver (PTL) tissues. We further evaluated N-WASP expression immunohistochemically in samples from 119 patients with HCC. The clinicopathologic and prognostic importance of N-WASP expression were also investigated.

Results. Western blotting showed that N-WASP expression was up-regulated in 15 of 19.FICC tissues (79%), compared with PTL ones. The N-WASP-positive rate in immunohistochemical staining also was greater in HCC (63/119, 53%) than that in PTL tissues (8/119, 6%). The up-regulated N-WASP expression in HCC tissues was correlated with absence of capsule formation and predicted less overall and disease-free survival. Multivariate analysis demonstrated that N-WASP was an independent prognostic factor for overall survival and was marginally important for disease-free survival.

Conclusion. These data establish that N-WASP is highly expressed in HCC and its strong prognostic importance. Therefore, the gene/protein might serve as a potential therapeutic target for HCC. (Surgery 2013;153:518-25.)

语种: 英语
WOS记录号: WOS:000316651000012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62481
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Hepat Biliary & Pancreat Surg Un, Beijing 100142, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Genet, Beijing 100142, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Dept Colorectal Surg Unit, Beijing 100142, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100191, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Canc Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Jin, Ke-Min,Lu, Min,Liu, Fang-Fang,et al. N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis[J]. SURGERY,2013,153(4):518-525.
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