IR@PKUHSC  > 北京大学精神卫生研究所
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A2BP1 gene polymorphisms association with olanzapine-induced weight gain
Dong, Licai1,2,3; Yan, Hao1,2,3; Huang, Xuebing1,2,3; Hu, Xiaofeng1,2,3; Yang, Yongfeng4,5; Ma, Cuicui6; Du, Bo7; Lu, Tianlan1,2,3; Jin, Chao6; Wang, Lifang1,2,3; Yu, Hao1,2,3; Dong, Zheng1,2,3; Li, Wenqiang4,5; Ruan, Yanyan1,2,3; Zhang, Hongyan1,2,3; Zhang, Hongxing4,5; Mi, Weifeng1,2,3; Ma, Wenbin6; Li, Keqing7; Lv, Luxian4,5; Zhang, Dai1,2,3,8; Yue, Weihua1,2,3
关键词Schizophrenia Ataxin-2 binding protein 1 Olanzapine Antipsychotic induced weight gain
刊名PHARMACOLOGICAL RESEARCH
2015-09-01
DOI10.1016/j.phrs.2015.06.003
99页:155-161
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; National Key Technology R&amp ; D Program of China ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; National Key Technology R&amp ; D Program of China ; National High Technology Research and Development Program of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]RECEPTOR GENE ; PIMA-INDIANS ; SCHIZOPHRENIA ; OBESITY ; BRAIN ; EXPRESSION ; VARIANTS ; ATAXIN-2 ; LINKAGE ; PROTEIN
英文摘要

The ataxin-2 binding protein 1 (A2BP1)gene is reported to be one of the susceptibility genes in schizophrenia, autism, and obesity. The aim of this study was to explore the association of A2BP1 gene polymorphisms with antipsychotic induced weight gain (AIWG) in Chinese Han population. Three hundred and twenty-eight patients with schizophrenia were followed-up for an 8-week period of treatment with olanzapine. The fasting weights of 328 patients were measured before and after the 8-week course of treatment. Four single nucleotide polymorphisms (SNPs: rs8048076, rs1478697, rs10500331, and rs4786847) of the A2BP1 gene were genotyped by polymerase chain reaction (PCR). We analyzed putative association of A2BP1 polymorphisms with AIWG of olanzapine using linear regression analysis and found that SNP rs1478697 was significantly associated with AIWG caused by olanzapine (p = 0.0012; Bonferroni corrected p = 0.0048). The association was replicated in another independent sample including 208 first-episode and drug-naive patients presenting with schizophrenia after a 4-week treatment with olanzapine (p = 0.0092; Bonferroni corrected p = 0.0368; meta p = 5.33 x 10(-5)). To explore the biological plausibility of A2BP1 in the pathogenesis of AIWG, we made expression analyses and eQTL analyses; these analyses showed that A2BP1 was highly expressed in whole brain tissues using the HBT database, and that rs1478697 has an expression quantitative trait locus effect in human cerebellar cortex tissues using the BRAINEAC database (p=2.50E-04). In conclusion, the rs1478697 in A2BP1 may be associated with AIWG induced by 8-week treatment with olanzapine. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81222017 ; 91232305 ; 7132182 ; 2015BAI13B01 ; 2012BAI01B06 ; 2008AA02Z401
资助者National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; National Key Technology R&amp ; D Program of China ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; National Key Technology R&amp ; D Program of China ; National High Technology Research and Development Program of China
WOS记录号WOS:000361580100017
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62498
Collection北京大学精神卫生研究所
作者单位1.Hebei Mental Hlth Ctr, Baoding 071000, Hebei, Peoples R China
2.Jinzhou Kangning Hosp, Jinzhou 121013, Liaoning, Peoples R China
3.Peking Univ, Inst Mental Hlth, Hosp 6, Beijing 100191, Peoples R China
4.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
5.Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
6.Xinxiang Med Univ, Affiliated Hosp 2, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China
7.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China
8.Peking Univ, Peking Tsinghua Ctr Life Sci, PKU IDG, McGovern Inst Brain Res, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Dong, Licai,Yan, Hao,Huang, Xuebing,et al. A2BP1 gene polymorphisms association with olanzapine-induced weight gain[J]. PHARMACOLOGICAL RESEARCH,2015,99:155-161.
APA Dong, Licai.,Yan, Hao.,Huang, Xuebing.,Hu, Xiaofeng.,Yang, Yongfeng.,...&Yue, Weihua.(2015).A2BP1 gene polymorphisms association with olanzapine-induced weight gain.PHARMACOLOGICAL RESEARCH,99,155-161.
MLA Dong, Licai,et al."A2BP1 gene polymorphisms association with olanzapine-induced weight gain".PHARMACOLOGICAL RESEARCH 99(2015):155-161.
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