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学科主题: 临床医学
题名:
The effect of moderate-dose versus double-dose statins on patients with acute coronary syndrome in China: Results of the CHILLAS trial
作者: Zhao, Shui-ping1; Yu, Bi-lian1; Peng, Dao-quan1; Huo, Yong2
关键词: Acute coronary syndrome ; LDL cholesterol ; Lipid-lowering ; Statins
刊名: ATHEROSCLEROSIS
发表日期: 2014-04-01
DOI: 10.1016/j.atherosclerosis.2013.12.003
卷: 233, 期:2, 页:707-712
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: DENSITY-LIPOPROTEIN CHOLESTEROL ; MYOCARDIAL-INFARCTION ; ATORVASTATIN ; MANAGEMENT ; THERAPY ; DISEASE ; EVENTS ; PRAVASTATIN ; PREVENTION ; GUIDELINES
英文摘要:

Background: Current guidelines recommend intensive low-density lipoprotein (LDL) cholesterol lowering with statins, with a target of 70 mg/dL (1.81 mmol/L) LDL cholesterol for those with a very high risk of coronary artery events. However, there is no multicenter study assessing the effect of intensive lipid-lowering therapy with statins on acute coronary syndrome (ACS) in a Chinese population with low baseline LDL cholesterol levels.

Methods and results: Patients (n = 1355) with ACS were treated with a moderate dose of statin (atorvastatin 10 mg/d, or equivalent dose of other statins, n = 675) or with an intensive dose of statin (atorvastatin, 20 or 40 mg/d, or equivalent dose of other statins, n = 680) for 2 years. The primary end points were cardiac death, non-fatal acute myocardial infarction (MI), revascularization, ischemic stroke and documented unstable angina or severe heart failure requiring emergency hospitalization. Baseline lipid levels were nearly identical in both groups with a mean LDL cholesterol level of 2.7 mmol/L (103 mg/dL). At 3 months, LDL cholesterol levels declined 20.2% in the moderate dose statin group and 26.6% in the intensive statin group, respectively (P < 0.001). In a 2-year follow-up, a primary end point event occurred in 20 patients in the moderate dose statin group and in 28 patients in the intensive statin group. There was no significant between-group difference in the primary outcome (hazard ratio, 1.39; 95% confidence interval [CI], 0.78-2.46; P = 0.245).

Conclusions: For ACS patients with a relatively low baseline LDL cholesterol level who received optimized current medication and interventional therapy, the incremental LDL cholesterol reduction of 6.4% achieved by double-dose statin did not bring significant clinical effectiveness. (C) 2014 Published by Elsevier Ireland Ltd.

语种: 英语
项目资助者: "The 11th Five-Year Plan" of PR China
WOS记录号: WOS:000334337200060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62503
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha, Hunan, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Shui-ping,Yu, Bi-lian,Peng, Dao-quan,et al. The effect of moderate-dose versus double-dose statins on patients with acute coronary syndrome in China: Results of the CHILLAS trial[J]. ATHEROSCLEROSIS,2014,233(2):707-712.
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