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学科主题: 临床医学
题名:
Atomoxetine pharmacokinetics in healthy Chinese subjects and effect of the CYP2D6*10 allele
作者: Cui, Yi M.; Teng, Choo H.; Pan, Alan X.; Yuen, Eunice; Yeo, Kwee P.; Zhou, Ying; Zhao, Xia; Long, Amanda J.; Bangs, Mark E.; Wise, Stephen D.
关键词: atomoxetine ; Chinese ; CYP2D6 ; CYP2D6*10 ; pharmacokinetics
刊名: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
发表日期: 2007-10-01
DOI: 10.1111/j.1365-2125.2007.02912.x
卷: 64, 期:4, 页:445-449
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: METABOLISM ; CYP2D6
英文摘要:

What is already known about this subject

Atomoxetine is a cytochrome P450 2D6 (CYP2D6) substrate and its pharmacokinetics has been characterized in a predominantly White population during clinical development.

There are scant East Asian pharmacokinetic data available.

The CYP2D6*10 allele is particularly prevalent in East Asian populations and may contribute to the known ethnic differences in CYP2D6 metabolic capacity.

What this study adds

The pharmacokinetics of multiple-dose 80 mg daily atomoxetine observed in Chinese healthy subjects appears comparable to previous data in other ethnic populations.

Homozygous CYP2D6*10 subjects appear to have higher exposures, but are not a clearly distinct group compared with other CYP2D6 extensive metabolizers.

To characterize atomoxetine pharmacokinetics, explore the effect of the homozygous CYP2D6*10 genotype on atomoxetine pharmacokinetics and evaluate the tolerability of atomoxetine, in healthy Chinese subjects.

Twenty-four subjects, all CYP2D6 extensive metabolizers (EM), were randomized to receive atomoxetine (40 mg qd for 3 days, then 80 mg qd for 7 days) or matching placebo (2 : 1 ratio) in a double-blind fashion. Atomoxetine serum concentrations were measured following single (40 mg) and multiple (80 mg) doses. Adverse events, clinical safety laboratory data and vital signs were assessed during the study.

Atomoxetine was rapidly absorbed with median time to maximum serum concentrations of approximately 1.5 h after single and multiple doses. Atomoxetine concentrations appeared to decrease monoexponentially with a mean apparent terminal half-life (t(1/2)) of approximately 4 h. The apparent clearance, apparent volume of distribution and t(1/2) following single and multiple doses were similar, suggesting linear pharmacokinetics with respect to time. Homozygous CYP2D6*10 subjects had 50% lower clearances compared with other EM subjects, resulting in twofold higher mean exposures. No clinically significant changes or abnormalities were noted in laboratory data and vital signs.

The pharmacokinetics of atomoxetine in healthy Chinese subjects appears comparable to other ethnic populations. Multiple dosing of 80 mg qd atomoxetine was well tolerated in this study.

语种: 英语
WOS记录号: WOS:000249482400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62504
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, First Hosp, Beijing, Peoples R China
2.Lilly NUS, Ctr Clin Pharmacol, Singapore, Singapore
3.Eli Lilly & Co, Indianapolis, IN USA

Recommended Citation:
Cui, Yi M.,Teng, Choo H.,Pan, Alan X.,et al. Atomoxetine pharmacokinetics in healthy Chinese subjects and effect of the CYP2D6*10 allele[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY,2007,64(4):445-449.
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