北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科  > 期刊论文
学科主题: 临床医学
题名:
In Vitro Antifungal Activity of Micafungin and Caspofungin Against Dermatophytes Isolated from China
作者: Bao, Ying-qiu1,2; Wan, Zhe1; Li, Ruo-yu1
关键词: Dermatophyte ; Antifungal susceptibility testing ; In vitro ; Caspofungin ; Micafungin
刊名: MYCOPATHOLOGIA
发表日期: 2013-02-01
DOI: 10.1007/s11046-012-9571-6
卷: 175, 期:1-2, 页:141-145
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: SUSCEPTIBILITIES ; INFECTION ; PATIENT ; FK463
英文摘要:

The aims of this study are to investigate the in vitro activities of micafungin and caspofungin that are two new echinocandin antifungal drugs against clinically isolated dermatophytes in China and to define MEC (minimal effective concentration) as the reading endpoints of this study in accordance with (Clinical and laboratory Standards Institute) CLSI M38-A2 reference.

Minimal effective concentrations (MECs) of micafungin and caspofungin for 82 dermatophyte strains were determined according to CLSI (formerly NCCLS) M38-A2 broth microdilution methods.

(1) The MEC90s of micafungin for Trichophyton violaceum and Trichophyton tonsurans were 0.25 mu g/mL, and for Microsporum canis and Trichophyton verrucosum were 0.06 mu g/mL. The MEC90s for Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum gypseum and Epidermophyton floccosum were 0.03 mu g/mL. (2) The MEC90s of caspofungin for T. rubrum, T. violaceum and T. tonsurans were 1 mu g/mL, and for T. mentagrophytes, M. canis, M. gypseum, E. floccosum and T. verrucosum were 0.5 mu g/mL. (3) Compared with caspofungin, micafungin demonstrated lower MEC value to dermatophytes (P < 0.05).

Micafungin has stronger in vitro antifungal activity than caspofungin.

语种: 英语
WOS记录号: WOS:000313968100017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62505
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Hosp, Dept Dermatol, Beijing 100730, Peoples R China
2.Peking Univ, Dept Dermatol, Hosp 1, Res Ctr Med Mycol, Beijing 100034, Peoples R China

Recommended Citation:
Bao, Ying-qiu,Wan, Zhe,Li, Ruo-yu. In Vitro Antifungal Activity of Micafungin and Caspofungin Against Dermatophytes Isolated from China[J]. MYCOPATHOLOGIA,2013,175(1-2):141-145.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Bao, Ying-qiu]'s Articles
[Wan, Zhe]'s Articles
[Li, Ruo-yu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Bao, Ying-qiu]‘s Articles
[Wan, Zhe]‘s Articles
[Li, Ruo-yu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace