IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
In Vitro Antifungal Activity of Micafungin and Caspofungin Against Dermatophytes Isolated from China
Bao, Ying-qiu1,2; Wan, Zhe1; Li, Ruo-yu1
关键词Dermatophyte Antifungal susceptibility testing In vitro Caspofungin Micafungin
刊名MYCOPATHOLOGIA
2013-02-01
DOI10.1007/s11046-012-9571-6
175期:1-2页:141-145
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]SUSCEPTIBILITIES ; INFECTION ; PATIENT ; FK463
英文摘要

The aims of this study are to investigate the in vitro activities of micafungin and caspofungin that are two new echinocandin antifungal drugs against clinically isolated dermatophytes in China and to define MEC (minimal effective concentration) as the reading endpoints of this study in accordance with (Clinical and laboratory Standards Institute) CLSI M38-A2 reference.

Minimal effective concentrations (MECs) of micafungin and caspofungin for 82 dermatophyte strains were determined according to CLSI (formerly NCCLS) M38-A2 broth microdilution methods.

(1) The MEC90s of micafungin for Trichophyton violaceum and Trichophyton tonsurans were 0.25 mu g/mL, and for Microsporum canis and Trichophyton verrucosum were 0.06 mu g/mL. The MEC90s for Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum gypseum and Epidermophyton floccosum were 0.03 mu g/mL. (2) The MEC90s of caspofungin for T. rubrum, T. violaceum and T. tonsurans were 1 mu g/mL, and for T. mentagrophytes, M. canis, M. gypseum, E. floccosum and T. verrucosum were 0.5 mu g/mL. (3) Compared with caspofungin, micafungin demonstrated lower MEC value to dermatophytes (P < 0.05).

Micafungin has stronger in vitro antifungal activity than caspofungin.

语种英语
WOS记录号WOS:000313968100017
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62505
Collection北京大学第一临床医学院_皮肤性病科
作者单位1.Beijing Hosp, Dept Dermatol, Beijing 100730, Peoples R China
2.Peking Univ, Dept Dermatol, Hosp 1, Res Ctr Med Mycol, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Bao, Ying-qiu,Wan, Zhe,Li, Ruo-yu. In Vitro Antifungal Activity of Micafungin and Caspofungin Against Dermatophytes Isolated from China[J]. MYCOPATHOLOGIA,2013,175(1-2):141-145.
APA Bao, Ying-qiu,Wan, Zhe,&Li, Ruo-yu.(2013).In Vitro Antifungal Activity of Micafungin and Caspofungin Against Dermatophytes Isolated from China.MYCOPATHOLOGIA,175(1-2),141-145.
MLA Bao, Ying-qiu,et al."In Vitro Antifungal Activity of Micafungin and Caspofungin Against Dermatophytes Isolated from China".MYCOPATHOLOGIA 175.1-2(2013):141-145.
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