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学科主题: 临床医学
题名:
Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system
作者: Chen Shan-shan1; Tang Chao-shu2,3; Jin Hong-fang1; Du Jun-bao1,3
关键词: cardiovascular diseases ; endogenous ; exogenous ; sulfur dioxide
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-06-20
DOI: 10.3760/cma.j.issn.0366-6999.2011.12.024
卷: 124, 期:12, 页:1901-1905
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: INHALED NITRIC-OXIDE ; PULMONARY-HYPERTENSION ; BLOOD-PRESSURE ; AIR-POLLUTION ; SERUM SULFITE ; DERIVATIVES ; RATS ; MYOCYTES ; H2S
英文摘要:

Objective Sulfur dioxide was considered to be toxic and detrimental to human health. However, this review highlights recent advances that suggest sulfur dioxide might be a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions.

Data sources The data used in this review were mainly from the studies reported in Medline and PubMed published from 1986 to 2010.

Study selection Original articles and critical reviews selected were relevant to exogenous and endogenous sulfur dioxide.

Results The sulfur dioxide/aspartate amino transferase pathway is endogenously generated in the cardiovascular system, and sulfur dioxide shows broad bioactive effects, such as antihypertension, vasodilation, and amelioration of vascular remodeling. A disturbed sulfur dioxide/aspartate amino transferase pathway is known to be involved in the pathogenesis of many cardiovascular diseases, such as ischemia-reperfusion injury, monocrotaline-induced pulmonary hypertension, athrosclerosis, spontaneous hypertension and hypoxic pulmonary hypertension. Furthermore, in experimental studies the prognosis of these cardiovascular diseases can be improved by targeting endogenous sulfur dioxide.

Conclusion The findings suggest that sulfur dioxide is a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions. Chin Med J 2011;124(12):1901-1905

语种: 英语
所属项目编号: 81070111 ; 30821001 ; 30801251 ; 2011CB503904 ; 7112130
项目资助者: National Natural Science Foundation of China ; Major State Basic Research Development Program ; Natural Science Foundation of Beijing
WOS记录号: WOS:000292350100026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62506
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Mol Cardiol, Beijing 100191, Peoples R China

Recommended Citation:
Chen Shan-shan,Tang Chao-shu,Jin Hong-fang,et al. Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system[J]. CHINESE MEDICAL JOURNAL,2011,124(12):1901-1905.
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