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Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system
Chen Shan-shan1; Tang Chao-shu2,3; Jin Hong-fang1; Du Jun-bao1,3
关键词cardiovascular diseases endogenous exogenous sulfur dioxide
刊名CHINESE MEDICAL JOURNAL
2011-06-20
DOI10.3760/cma.j.issn.0366-6999.2011.12.024
124期:12页:1901-1905
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]INHALED NITRIC-OXIDE ; PULMONARY-HYPERTENSION ; BLOOD-PRESSURE ; AIR-POLLUTION ; SERUM SULFITE ; DERIVATIVES ; RATS ; MYOCYTES ; H2S
英文摘要

Objective Sulfur dioxide was considered to be toxic and detrimental to human health. However, this review highlights recent advances that suggest sulfur dioxide might be a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions.

Data sources The data used in this review were mainly from the studies reported in Medline and PubMed published from 1986 to 2010.

Study selection Original articles and critical reviews selected were relevant to exogenous and endogenous sulfur dioxide.

Results The sulfur dioxide/aspartate amino transferase pathway is endogenously generated in the cardiovascular system, and sulfur dioxide shows broad bioactive effects, such as antihypertension, vasodilation, and amelioration of vascular remodeling. A disturbed sulfur dioxide/aspartate amino transferase pathway is known to be involved in the pathogenesis of many cardiovascular diseases, such as ischemia-reperfusion injury, monocrotaline-induced pulmonary hypertension, athrosclerosis, spontaneous hypertension and hypoxic pulmonary hypertension. Furthermore, in experimental studies the prognosis of these cardiovascular diseases can be improved by targeting endogenous sulfur dioxide.

Conclusion The findings suggest that sulfur dioxide is a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions. Chin Med J 2011;124(12):1901-1905

语种英语
WOS记录号WOS:000292350100026
项目编号81070111 ; 30821001 ; 30801251 ; 2011CB503904 ; 7112130
资助机构National Natural Science Foundation of China ; Major State Basic Research Development Program ; Natural Science Foundation of Beijing
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62506
专题北京大学第一临床医学院_儿科
北京大学临床肿瘤学院_移植与免疫治疗病区
作者单位1.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Mol Cardiol, Beijing 100191, Peoples R China
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GB/T 7714
Chen Shan-shan,Tang Chao-shu,Jin Hong-fang,et al. Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system[J]. CHINESE MEDICAL JOURNAL,2011,124(12):1901-1905.
APA Chen Shan-shan,Tang Chao-shu,Jin Hong-fang,&Du Jun-bao.(2011).Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system.CHINESE MEDICAL JOURNAL,124(12),1901-1905.
MLA Chen Shan-shan,et al."Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system".CHINESE MEDICAL JOURNAL 124.12(2011):1901-1905.
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