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Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like "nightmares" in rats
Yu, Bin; Cui, Su-Ying; Zhang, Xue-Qiong; Cui, Xiang-Yu; Li, Sheng-Jie; Sheng, Zhao-Fu; Cao, Qing; Huang, Yuan-Li; Xu, Ya-Ping; Lin, Zhi-Ge; Yang, Guang; Song, Jin-Zhi; Ding, Hui; Zhang, Yong-He
刊名SCIENTIFIC REPORTS
2015-11-04
DOI10.1038/srep15976
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SENSORY INSULAR CORTEX ; TERRORIST ATTACKS ; SAFETY SIGNALS ; MEMORY ; SLEEP ; DISORDER ; FEAR ; REPRESENTATION ; CONSOLIDATION ; EXTINCTION
英文摘要

Posttraumatic nightmares are a core component of posttraumatic stress disorder (PTSD) and mechanistically linked to the development and maintenance of this disorder, but little is known about their mechanism. We utilized a communication box to establish an animal model of physiological stress (foot-shock [FS]) and psychological stress (PS) to mimic the direct suffering and witnessing of traumatic events. Twenty-one days after traumatic stress, some of the experimental animals presented startled awakening (i.e., were startled awake by a supposed "nightmare") with different electroencephalographic spectra features. Our neuroanatomical results showed that the secondary somatosensory cortex and primary auditory cortex may play an important role in remote traumatic memory retrieval in FS "nightmare" (FSN) rats, whereas the temporal association cortex may play an important role in PS "nightmare" (PSN) rats. The FSN and PSN groups possessed common emotion evocation circuits, including activation of the amygdala and inactivation of the infralimbic prefrontal cortex and ventral anterior cingulate cortex. The decreased activity of the granular and dysgranular insular cortex was only observed in PSN rats. The present results imply that different types of stress may cause PTSD-like "nightmares" in rodents and identified the possible neurocircuitry of memory retrieval and emotion evocation.

语种英语
WOS记录号WOS:000364035600001
项目编号81173031 ; 81202511 ; 81302746
资助机构National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62507
专题北京大学基础医学院_药理学系
北京大学医学部管理机构_医学部
北京大学基础医学院
北京大学第三临床医学院_老年内科
作者单位Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China
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GB/T 7714
Yu, Bin,Cui, Su-Ying,Zhang, Xue-Qiong,et al. Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like "nightmares" in rats[J]. SCIENTIFIC REPORTS,2015,5.
APA Yu, Bin.,Cui, Su-Ying.,Zhang, Xue-Qiong.,Cui, Xiang-Yu.,Li, Sheng-Jie.,...&Zhang, Yong-He.(2015).Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like "nightmares" in rats.SCIENTIFIC REPORTS,5.
MLA Yu, Bin,et al."Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like "nightmares" in rats".SCIENTIFIC REPORTS 5(2015).
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