IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Association of polymorphisms in drug transporter genes (SLCO1B1 and SLC10A1) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort
Chen, Ru1; Wang, Jing1; Tang, Shaowen2; Zhang, Yuan3; Lv, Xiaozhen4,5; Wu, Shanshan1; Xia, Yinyin6; Deng, Peiyuan7; Ma, Yu8; Tu, Dehua9; Chen, Dafang1; Zhan, Siyan1
关键词Drug transporter Anti-tuberculosis drug Hepatotoxicity
刊名TUBERCULOSIS
2015
DOI10.1016/j.tube.2014.11.004
95期:1页:68-74
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Microbiology ; Respiratory System
研究领域[WOS]Immunology ; Microbiology ; Respiratory System
关键词[WOS]INDUCED LIVER-INJURY ; BILE-ACID TRANSPORTERS ; HEPATIC-UPTAKE ; RISK-FACTORS ; PHARMACOKINETICS ; PRAVASTATIN ; POPULATION ; HAPLOTYPE ; RIFAMPIN ; PHARMACOGENETICS
英文摘要

This study investigated the association between genetic variants in two hepatic uptake transporter genes (SLCO1B1 and SLC10A1) and the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in a Chinese cohort. The frequencies and distributions of single nucleotide polymorphisms (SNPs) and haplotypes of these genes were compared among 89 incident ATDH cases and 356 matched ATDH-free controls using a multivariate conditional logistic regression analysis. After correction for potential confounding factors, significant differences were found in polymorphism of rs4149014 under an addictive model (P = 0.008) and a recessive model (P = 0.016). The result of haplotype analysis suggested that patients carrying at least one SLCO1B1*15 haplotype had a higher risk of ATDH (odds ratio (OR) = 1.74, 95% confidence intervals (CI): 1.04-2.90, P = 0.034) in comparison with those carrying SLCO1B1*1a or SLCO1B1*1b haplotypes. These findings indicate that genetic variants of SLCO1B1 are associated with the development of ATDH in Chinese population. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000346857300011
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62512
专题北京大学公共卫生学院
作者单位1.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
2.State Food & Drug Adm, Ctr Drug Reassessment, Beijing, Peoples R China
3.Beijing Inst TB Control, Dept TB Treatment, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
5.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China
6.McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada
7.Peking Univ, Inst Mental Hlth, Div Clin Res, Beijing 100871, Peoples R China
8.Chinese Ctr Dis Control & Prevent, Ctr TB Control & Prevent, Beijing, Peoples R China
9.Beijing TB & Thorac Tumor Res Inst, Dept TB Treatment, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Chen, Ru,Wang, Jing,Tang, Shaowen,et al. Association of polymorphisms in drug transporter genes (SLCO1B1 and SLC10A1) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort[J]. TUBERCULOSIS,2015,95(1):68-74.
APA Chen, Ru.,Wang, Jing.,Tang, Shaowen.,Zhang, Yuan.,Lv, Xiaozhen.,...&Zhan, Siyan.(2015).Association of polymorphisms in drug transporter genes (SLCO1B1 and SLC10A1) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort.TUBERCULOSIS,95(1),68-74.
MLA Chen, Ru,et al."Association of polymorphisms in drug transporter genes (SLCO1B1 and SLC10A1) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort".TUBERCULOSIS 95.1(2015):68-74.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Ru]的文章
[Wang, Jing]的文章
[Tang, Shaowen]的文章
百度学术
百度学术中相似的文章
[Chen, Ru]的文章
[Wang, Jing]的文章
[Tang, Shaowen]的文章
必应学术
必应学术中相似的文章
[Chen, Ru]的文章
[Wang, Jing]的文章
[Tang, Shaowen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。