北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 计划生育与生殖医学科  > 期刊论文
学科主题: 临床医学
题名:
Androgen replacement therapy improves psychological distress and health-related quality of life in late onset hypogonadism patients in Chinese population
作者: Zhang Xiao-wei2; Liu Zhen-hua2; Hu Xiao-wei3; Yuan Ye-qing2; Bai Wen-jun2; Wang Xiao-feng2; Shen Huan1; Zhao Yong-ping1
关键词: androgen replacement therapy ; late onset hypogonadism ; psychological distress
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-11-05
DOI: 10.3760/cma.j.issn.0366-6999.2012.21.011
卷: 125, 期:21, 页:3806-3810
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: TESTOSTERONE THERAPY ; MEN ; DEPRESSION ; DEFICIENCY ; QUESTIONNAIRE ; ANXIETY ; STRESS ; MALES
英文摘要:

Background Late onset hypogonadism negatively impacts on men′s psychological well-being. This study was conducted to examine the interrelationship among symptoms of testosterone deficiency, psychological well-being, and quality of life.

Methods Eligible subjects were randomized into active treatment and control groups, and were asked to complete the following questionnaires at baseline and month 6: aging male′s symptoms (AMS) rating scale, hospital anxiety and depression scale (HADS), perceived stress scale (PSS) and the short form health survey-12 (SF-12). In this study, men were treated and monitored for 6 months with oral testosterone undecanoate (TU) capsules or vitamin E/C capsules in a single-blinded fashion. All in the active treatment group were administered a total of 120-160 mg TU orally on a daily basis. Total and free T levels between baseline and month 6 were compared.

Results One hundred and sixty eligible subjects were recruited and followed up. In the active treatment group, total serum testosterone concentrations before and after intervention were (7.98 +/- 0.73) nmol/L and (13.7 +/- 1.18) nmol/L. The mean HADS anxiety subscale scores for the subjects at baseline and at month 6 were 3.47 +/- 0.4 and 1.72 +/- 0.2, respectively (t=1.526, P<0.05). Additionally, the mean HADS depression subscale scores were 4.91 +/- 0.6 and 2.39 +/- 0.3, respectively (t=3.466, P<0.05). The mean scores on PSS for the subjects at baseline and at month 6 were 12.88 +/- 2.1 and 9.83 +/- 1.7, respectively (t=4.009, P<0.05). Significantly improved SF-12 could be observed (t=1.433 and 1.118, respectively; both P<0.05). No significant changes were observed in the control group at month 6.

Conclusion Androgen replacement not only improves androgen deficiency associated symptoms, but also enhances comprehensive improvement in psychological issues. (No. ChiCTR-TRC-11001811) Chin Med J 2012;125(21):3806-3810

语种: 英语
WOS记录号: WOS:000311265200011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62516
Appears in Collections:北京大学第二临床医学院_计划生育与生殖医学科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Peoples Hosp, Reprod Med Ctr, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China
3.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China

Recommended Citation:
Zhang Xiao-wei,Liu Zhen-hua,Hu Xiao-wei,et al. Androgen replacement therapy improves psychological distress and health-related quality of life in late onset hypogonadism patients in Chinese population[J]. CHINESE MEDICAL JOURNAL,2012,125(21):3806-3810.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang Xiao-wei]'s Articles
[Liu Zhen-hua]'s Articles
[Hu Xiao-wei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang Xiao-wei]‘s Articles
[Liu Zhen-hua]‘s Articles
[Hu Xiao-wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace