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学科主题临床医学
Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin-1
Zhang, Zhe; Nie, Fangfei; Chen, Xinlei; Qin, Zelian; Kang, Chunfu; Chen, Bin; Ma, Jianxun; Pan, Bolin; Ma, Yongguang
关键词periostin fibroblast keloid endothelial cells angiogenesis
刊名MOLECULAR MEDICINE REPORTS
2015-02-01
DOI10.3892/mmr.2014.2827
11期:2页:857-864
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; HYPERTROPHIC SCARS ; CANCER-CELLS ; FIBROBLASTS ; PROLIFERATION ; APOPTOSIS ; ETIOLOGY
英文摘要

Periostin, a secreted extracellular matrix protein, is highly expressed in wound healing and in various types of human cancer and is involved in angiogenesis. Keloids, considered dermal benign tumors, are granulomatous lesions characterized by capillary proliferation. However, the underlying regulatory mechanism of angiogenesis in keloids remains to be elucidated. The present study aimed to examine the effect of periostin on angiogenesis in keloids. The expression of periostin was upregulated and the vessel density was higher in human keloids compared with normal tissue, observed following staining with CD31 and CD105. Periostin demonstrated a markedly positive correlation with blood vessel density, which was assessed using CD31 staining (r=0.711; P<0.01) and a weak correlation was observed using CD105 staining (r=0.251; P<0.01). Conditioned medium from keloid fibroblasts (KFs) promoted the migration and tube formation of human umbilical vein endothelial cells (HUVECs) compared with normal fibroblasts and this effect may have been abrogated by the short hairpin RNA knockdown of periostin. Treatment with recombinant human periostin promoted the migration and tube formation of HUVECs by activating the extracellular signal-regulated kinase 1/2 and focal adhesion kinase signaling pathway. In addition, periostin increased the secretion of vascular endothelial growth factor and angiopoietin-1 in the KFs. In conclusion, these data suggested that upregulation in the level of periostin may promote angiogenesis directly and indirectly in keloids and may be a key factor in keloid development. Periostin may, therefore, be a promising therapeutic target in the treatment of keloids and other angioproliferative diseases.

语种英语
WOS记录号WOS:000349506400014
项目编号30973126 ; 20130001110095
资助机构National Natural Science Foundation of China ; Ministry of Education Doctoral Foundation of the People&prime ; s Republic of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62517
专题北京大学第三临床医学院_成形外科
北京大学第二临床医学院_血液科
作者单位Peking Univ Third Hosp, Dept Plast Surg, Beijing 100191, Peoples R China
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GB/T 7714
Zhang, Zhe,Nie, Fangfei,Chen, Xinlei,et al. Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin-1[J]. MOLECULAR MEDICINE REPORTS,2015,11(2):857-864.
APA Zhang, Zhe.,Nie, Fangfei.,Chen, Xinlei.,Qin, Zelian.,Kang, Chunfu.,...&Ma, Yongguang.(2015).Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin-1.MOLECULAR MEDICINE REPORTS,11(2),857-864.
MLA Zhang, Zhe,et al."Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin-1".MOLECULAR MEDICINE REPORTS 11.2(2015):857-864.
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