IR@PKUHSC  > 北京大学第一临床医学院  > 男科中心
学科主题临床医学
Stem Cell Therapy for Erectile Dysfunction: A Critical Review
Lin, Ching-Shwun1; Xin, Zhong-Cheng2; Wang, Zhong3; Deng, Chunhua4; Huang, Yun-Ching5; Lin, Guiting1; Lue, Tom F.1
刊名STEM CELLS AND DEVELOPMENT
2012-02-10
DOI10.1089/scd.2011.0303
21期:3页:343-351
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Cell & Tissue Engineering ; Hematology ; Medicine, Research & Experimental ; Transplantation
资助者Arthur Rock Foundation ; National Institutes of Health ; Arthur Rock Foundation ; National Institutes of Health
研究领域[WOS]Cell Biology ; Hematology ; Research & Experimental Medicine ; Transplantation
关键词[WOS]CAVERNOUS NERVE INJURY ; MARROW STROMAL CELLS ; SMOOTH-MUSCLE-CELLS ; RAT MODEL ; BONE-MARROW ; RADICAL PROSTATECTOMY ; CORPUS CAVERNOSUM ; GROWTH-FACTOR ; TISSUE ; TRANSPLANTATION
英文摘要

Erectile dysfunction (ED) is a prevailing health problem that seriously impacts quality of life. Current treatment options are less effective for patients having cavernous nerve (CN) injury or diabetes mellitus-related ED. These 2 types of ED are thus the main focus of past and current stern cell (SC) therapy studies. In a total of 16 studies so far, rats were exclusively used as disease models and SCs were mostly derived from bone marrow, adipose tissue, or skeletal muscle. For tracking, SCs were labeled with LacZ, green fluorescent protein, 4′,6-diamidino-2-phenylindole, DiI, bromodeoxyuridine, or 5-ethyny1-2-deoxyuridine, some of which might have led to data misinterpretation. SC transplantation was done exclusively by intracavernous (IC) injection, which has been recently shown to have systemic effects. Functional assessment was done exclusively by measuring increases of IC pressure during electrostimulation of CN. Histological assessment usually focused on endothelial, smooth muscle, and CN contents in the penis. In general, favorable outcomes have been obtained in all trials so far, although whether SCs had differentiated into specific cell lineages remains controversial. Recent studies have shown that intracavernously injected SCs rapidly escaped the penis and homed into bone marrow. This could perhaps explain why intracavernously injected SCs had systemic antidiabetic effects and prolonged anti-ED effects. These hypotheses and the differentiation-versus-paracrine debate require further investigation.

语种英语
所属项目编号DK045370
资助者Arthur Rock Foundation ; National Institutes of Health ; Arthur Rock Foundation ; National Institutes of Health
WOS记录号WOS:000300266900001
引用统计
被引频次:57[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62521
专题北京大学第一临床医学院_男科中心
作者单位1.Univ Calif San Francisco, Sch Med, Dept Urol, Knuppe Mol Urol Lab, San Francisco, CA 94143 USA
2.Peking Univ, Hosp 1, Androl Ctr, Beijing 100871, Peoples R China
3.Shanghai Jiao Tong Univ, Coll Med, Peoples Hosp 9, Dept Urol, Shanghai 200030, Peoples R China
4.Sun Yet Sen Univ, Affiliated Hosp 1, Dept Urol, Guangzhou, Guangdong, Peoples R China
5.Chang Gung Mem Hosp, Dept Surg, Div Urol, Chiayi, Taiwan
推荐引用方式
GB/T 7714
Lin, Ching-Shwun,Xin, Zhong-Cheng,Wang, Zhong,et al. Stem Cell Therapy for Erectile Dysfunction: A Critical Review[J]. STEM CELLS AND DEVELOPMENT,2012,21(3):343-351.
APA Lin, Ching-Shwun.,Xin, Zhong-Cheng.,Wang, Zhong.,Deng, Chunhua.,Huang, Yun-Ching.,...&Lue, Tom F..(2012).Stem Cell Therapy for Erectile Dysfunction: A Critical Review.STEM CELLS AND DEVELOPMENT,21(3),343-351.
MLA Lin, Ching-Shwun,et al."Stem Cell Therapy for Erectile Dysfunction: A Critical Review".STEM CELLS AND DEVELOPMENT 21.3(2012):343-351.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lin, Ching-Shwun]的文章
[Xin, Zhong-Cheng]的文章
[Wang, Zhong]的文章
百度学术
百度学术中相似的文章
[Lin, Ching-Shwun]的文章
[Xin, Zhong-Cheng]的文章
[Wang, Zhong]的文章
必应学术
必应学术中相似的文章
[Lin, Ching-Shwun]的文章
[Xin, Zhong-Cheng]的文章
[Wang, Zhong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。