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学科主题临床医学
Beilong virus, a novel paramyxovirus with the largest genome of non-segmented negative-stranded RNA viruses
Li, Z; Yu, M; Zhang, H; Magoffin, DE; Jack, PJM; Hyatt, A; Wang, HY; Wang, LF
关键词Beilong virus J-virus paramyxovirus rodents
刊名VIROLOGY
2006-03-01
DOI10.1016/j.virol.2005.10.039
346期:1页:219-228
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]MOLECULAR CHARACTERIZATION ; HENDRA VIRUS ; FAMILY PARAMYXOVIRIDAE ; FUSION PROTEIN ; MOSSMAN-VIRUS ; FRUIT BATS ; SEQUENCE ; GENE ; CELLS ; IDENTIFICATION
英文摘要

During a subtraction study on gene expression in human kidney mesangial cells (HMCs), cDNA clones with sequence homology to paramyxovirus P, M and F genes were isolated. Subsequent investigation revealed that this particular HMC line was infected with a previously Unknown paramyxovirus. Here, we report the isolation and genome characterization of this new virus, now named Beilong virus (BeV). The genome of BeV is 19,2 12 nucleotides (nt) in length and is the largest among all known members of the order Mononegavirales. The BeV genome contains eight genes in the order 3′-N-P/V/C-M-F-SH-TM-G-L-5′. The SH and TM genes code for a small hydrophobic protein of 76 an and a transmembrane protein of 254 aa, respectively. The BeV G gene, at 4527 nt, codes for an attachment protein of 734 aa and contains two additional open reading frames (OPFs) in the 3′ half of the gene, coding for putative proteins of 299 and 394 an in length. Although the exact origin of BeV is presently unknown, we provide evidence indicating that BeV was present in a rat mesangial cell line used in the same laboratory prior to the acquisition of the HMC line, suggesting a potential rodent origin for BeV. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000235930400020
Citation statistics
Cited Times:60[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62527
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
2.CSIRO, Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia
3.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Li, Z,Yu, M,Zhang, H,et al. Beilong virus, a novel paramyxovirus with the largest genome of non-segmented negative-stranded RNA viruses[J]. VIROLOGY,2006,346(1):219-228.
APA Li, Z.,Yu, M.,Zhang, H.,Magoffin, DE.,Jack, PJM.,...&Wang, LF.(2006).Beilong virus, a novel paramyxovirus with the largest genome of non-segmented negative-stranded RNA viruses.VIROLOGY,346(1),219-228.
MLA Li, Z,et al."Beilong virus, a novel paramyxovirus with the largest genome of non-segmented negative-stranded RNA viruses".VIROLOGY 346.1(2006):219-228.
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