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A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines
Zhao, F; Yan, J; Deng, SJ; Lan, LX; He, F; Kuang, B; Zeng, HH
关键词thioredoxin reductase apoptosis cellular sensitivity Bcl-2/Bax caspase-3
刊名CANCER LETTERS
2006-05-08
DOI10.1016/j.canlet.2005.05.010
236期:1页:46-53
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]NF-KAPPA-B ; CANCER-CELLS ; RIBONUCLEOTIDE REDUCTASE ; GLUTATHIONE-REDUCTASE ; EXPRESSION ; SELENIUM ; PROLIFERATION ; MECHANISM ; BINDING
英文摘要

Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1, 2[his (1,2-Benzisoselenazolone-3 (2H)-ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on A549, HeLa, Bel-7402, BGC823 and KB cell lines. After treated with BBSKE, a good linear correlation coefficient (r >= 0.989) between TrxR activity and cell viability exists in each cell line together with cell growth/proliferation inhibition and apoptosis through Bcl2/Bax and Caspase-3 pathways. These results suggest that there exists some relationship between TrxR inactivation and growth/proliferation inhibition or apoptosis in the investigated cell lines. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000237679600006
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62530
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Zhao, F,Yan, J,Deng, SJ,et al. A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines[J]. CANCER LETTERS,2006,236(1):46-53.
APA Zhao, F.,Yan, J.,Deng, SJ.,Lan, LX.,He, F.,...&Zeng, HH.(2006).A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines.CANCER LETTERS,236(1),46-53.
MLA Zhao, F,et al."A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines".CANCER LETTERS 236.1(2006):46-53.
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