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学科主题: 临床医学
题名:
The Application of Fourier Transform Infrared Technology in Biomedical Sphere
作者: Zhang Xiao-qing1; Xu Zhi1; Ling Xiao-feng1; Xu Yi-zhuang2; Wu Jin-guang2
关键词: Mid-infrared spectroscopy ; Biomedical diagnosis ; Tissue analysis ; Malignancy
刊名: SPECTROSCOPY AND SPECTRAL ANALYSIS
发表日期: 2010
DOI: 10.3964/j.issn.1000-0593(2010)01-0030-05
卷: 30, 期:1, 页:30-34
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Spectroscopy
研究领域[WOS]: Spectroscopy
关键词[WOS]: IR MICROSPECTROSCOPY ; PIGMENT GALLSTONES ; STRUCTURAL-CHANGES ; IN-VITRO ; SPECTROSCOPY ; CANCER ; CELLS ; TISSUES ; TUMOR
英文摘要:

The authors systemically reviewed the development of FTIR technology and its innovative advances during the past fifty years. FTIR technique was once abandoned after initial exploration in biomedical fields, which could not confirm its reliability and credibility. After technological innovation and refined numerical analysis methods, FTIR technique has been applied to a wide range of fields, from single cellular to the complex biomedical tissue components. Nowadays, mature and advanced FTIR technology, such as FTIR microspectrometer and FTIR imaging system, with the aid of pattern recognition and tissue microarray, greatly facilitated the large parallel scale investigation of molecular structure. The recent development of FTIR spectroscopic imaging has enhanced our capability to examine, on a microscopic scale, the spatial distribution of vibrational spectroscopic Signatures of materials spanning the physical and biomedical disciplines. The integration of instrumentation development, theoretical analyses to provide guidelines for imaging practice, novel data processing algorithms, and the introduction of the technique to new fields. FTIR technique has helped analyze the complex components of bile stones, which persisted to be a vexing problem and causing high death rate in China. Besides, FTIR technology could provide reliable information in discriminating benign and malignancy. It has been used in detecting thyroid nodules, mammary gland, gastrointestinal tract, cardiovascular and prostate diseases, and parotid gland tissue in combination with ATR detecting device, and has broad clinical application prospects. Till now, FTIR technology has achieved the fast and accurate diagnosis for freshly dissected tissues such as discriminating thyroid carcinoma from nodular goiter intraoperatively. However, further investigations need to be done in this sphere to achieve greater accomplishments.

语种: 中文
WOS记录号: WOS:000273230500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62532
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Zhang Xiao-qing,Xu Zhi,Ling Xiao-feng,et al. The Application of Fourier Transform Infrared Technology in Biomedical Sphere[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2010,30(1):30-34.
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